Arne Jensen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Research Interests
Arne Jensen has a total of 305 co-authors. Here are the top co-authors by number of shared publications:
R. Berger
18 shared publicationsRichard Berger
From the * Department of Obstetrics and Gynecology, University of Maastricht, Maastricht, Netherlands; and †Department of Obstetrics and Gynecology, University of Bochum, Bochum, Germany
15 shared publicationsW. Künzel
13 shared publicationsYves Garnier
From the * Department of Obstetrics and Gynecology, University of Maastricht, Maastricht, Netherlands; and †Department of Obstetrics and Gynecology, University of Bochum, Bochum, Germany
11 shared publicationsR Berger
9 shared publicationsM. Hohmann
6 shared publications
Latest Publications
- 16 September 2024
- Published by Elsevier in European Journal of Obstetrics & Gynecology and Reproductive Biology
- Vol. 302, 391-393
Validated predictive risk analyses for neonatal brain injury before birth
- 16 September 2024
- Published by Elsevier in European Journal of Obstetrics & Gynecology and Reproductive Biology
- Vol. 302, 391-393
Validated predictive risk analyses for neonatal brain injury before birth
- Open Access
- 8 January 2024
- Published by Elsevier in AJOG Global Reports
- Vol. 4 (1) , 100305
Differential effects of growth restriction and immaturity on predicted psychomotor development at 4 years of age in preterm infants
- 8 January 2024
- Published by Elsevier in AJOG Global Reports
- Vol. 4 (1) , 100305
Open AccessDifferential effects of growth restriction and immaturity on predicted psychomotor development at 4 years of age in preterm infants
- Open Access
- 8 May 2023
- Published by Elsevier in AJOG Global Reports
- Vol. 3 (4) , 100219
Growth variables and obstetrical risk factors in newborns are associated with psychomotor development at preschool age
- 8 May 2023
- Published by Elsevier in AJOG Global Reports
- Vol. 3 (4) , 100219
Open AccessGrowth variables and obstetrical risk factors in newborns are associated with psychomotor development at preschool age
- Open Access
- 12 December 2022
- Published by Walter de Gruyter GmbH in Journal of Perinatal Medicine
- Vol. 51 (6) , 737-751
Cerebral palsy – brain repair with stem cells
Cerebral palsy, the most common disability in childhood, is a devastating non-progressive ailment of the infants’ brain with lifelong sequelae, e.g., spastic paresis, chronic pain, inability to walk, intellectual disability, behavioral disorders, for which there is no cure at present. CP may develop after pediatric brain damage caused, e.g., by hypoxic-ischemia, periventricular leukomalacia, intracranial hemorrhage, hypoxic-ischemic encephalopathy, trauma, stroke, and infection. About 17 million people worldwide live with cerebral palsy as a result of pediatric brain damage. This reflects both the magnitude of the personal, medical, and socioeconomic global burden of this brain disorder and the overt unmet therapeutic needs of the pediatric population. This review will focus on recent preclinical, clinical, and regulatory developments in cell therapy for infantile cerebral palsy by transplantation of cord blood derived mononuclear cells from bench to bedside. The body of evidence suggests that cord blood cell therapy of cerebral palsy in the autologous setting is feasible, effective, and safe, however, adequately powered phase 3 trials are overdue.
- 12 December 2022
- Published by Walter de Gruyter GmbH in Journal of Perinatal Medicine
- Vol. 51 (6) , 737-751
Open AccessCerebral palsy – brain repair with stem cells
Cerebral palsy, the most common disability in childhood, is a devastating non-progressive ailment of the infants’ brain with lifelong sequelae, e.g., spastic paresis, chronic pain, inability to walk, intellectual disability, behavioral disorders, for which there is no cure at present. CP may develop after pediatric brain damage caused, e.g., by hypoxic-ischemia, periventricular leukomalacia, intracranial hemorrhage, hypoxic-ischemic encephalopathy, trauma, stroke, and infection. About 17 million people worldwide live with cerebral palsy as a result of pediatric brain damage. This reflects both the magnitude of the personal, medical, and socioeconomic global burden of this brain disorder and the overt unmet therapeutic needs of the pediatric population. This review will focus on recent preclinical, clinical, and regulatory developments in cell therapy for infantile cerebral palsy by transplantation of cord blood derived mononuclear cells from bench to bedside. The body of evidence suggests that cord blood cell therapy of cerebral palsy in the autologous setting is feasible, effective, and safe, however, adequately powered phase 3 trials are overdue.
- Open Access
- 2 October 2022
- Published by Elsevier in AJOG Global Reports
- Vol. 2 (4) , 100115
Association of weight-length ratio at birth with psychomotor trajectories among preschool-aged children
- 2 October 2022
- Published by Elsevier in AJOG Global Reports
- Vol. 2 (4) , 100115
Open AccessAssociation of weight-length ratio at birth with psychomotor trajectories among preschool-aged children
- 4 May 2019
- Published by Austin Publishing Group in Journal of Stem Cell Research and Transplantation
- Vol. 6 (1)
Pediatric Stroke and Cell-Based Treatment – Pivotal Role of Brain Plasticity
- 4 May 2019
- Published by Austin Publishing Group in Journal of Stem Cell Research and Transplantation
- Vol. 6 (1)
Pediatric Stroke and Cell-Based Treatment – Pivotal Role of Brain Plasticity
- Open Access
- 28 February 2018
- Published by Wiley in Obstetrics and Gynecology International
- Vol. 2018, 1-12
White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link
Background. White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occurring unexplained. Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved. Objective. To explore both incidence of and morphometric risk factors for WMD in term-born infants. Study Design. We related growth variables and risk factors of term-born infants to WMD (61/4,725) using odds ratios of z-score bands. Results. The key result is the novel observation that head circumference is a prime and unique index for WMD in term-born neonates over the whole range of centiles (U-shaped; WMD (%) = 3.1168–0.12797∗HC (centile) + 0.0014741∗HC2; ). This suggests different mechanisms for WMD in the lowest and highest z-score band. In the latter, cephalic pressure gradients and prolonged labor with preserved neonatal vitality prevail, whereas in the previous one, acute and chronic oxygen deprivation with reduced vitality predominate. Conclusions. The fact that seemingly healthy term-born neonates are not screened by head imaging, in spite of both large head circumference and prolonged labor, is considered to be the missing link between the insult that escapes diagnosis and the development of unexplained developmental delay and cerebral palsy in childhood.Dedicated to Lawrence D. Longo (1926–2016)- 28 February 2018
- Published by Wiley in Obstetrics and Gynecology International
- Vol. 2018, 1-12
Open AccessWhite Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link
Background. White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occurring unexplained. Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved. Objective. To explore both incidence of and morphometric risk factors for WMD in term-born infants. Study Design. We related growth variables and risk factors of term-born infants to WMD (61/4,725) using odds ratios of z-score bands. Results. The key result is the novel observation that head circumference is a prime and unique index for WMD in term-born neonates over the whole range of centiles (U-shaped; WMD (%) = 3.1168–0.12797∗HC (centile) + 0.0014741∗HC2; ). This suggests different mechanisms for WMD in the lowest and highest z-score band. In the latter, cephalic pressure gradients and prolonged labor with preserved neonatal vitality prevail, whereas in the previous one, acute and chronic oxygen deprivation with reduced vitality predominate. Conclusions. The fact that seemingly healthy term-born neonates are not screened by head imaging, in spite of both large head circumference and prolonged labor, is considered to be the missing link between the insult that escapes diagnosis and the development of unexplained developmental delay and cerebral palsy in childhood.Dedicated to Lawrence D. Longo (1926–2016) - 1 July 2016
- Published by Elsevier in American Journal of Obstetrics and Gynecology
- Vol. 215 (1) , 120-121
In memoriam: Lawrence Daniel Longo (1926-2016)
- 1 July 2016
- Published by Elsevier in American Journal of Obstetrics and Gynecology
- Vol. 215 (1) , 120-121
In memoriam: Lawrence Daniel Longo (1926-2016)
- 15 June 2016
- Published by Taylor & Francis in Regenerative Medicine
- Vol. 11 (5) , 465-474
Factors Influencing Yield and Neuronal Differentiation of Mesenchymal Stem Cells from Umbilical Cord Blood and Matrix
Aim: Umbilical cord blood and Wharton's jelly (WJ) are potential sources of mesenchymal stem cells (MSCs). We investigated whether harvesting and donor characteristics affected yield and neuronal differentiation, and compared human umbilical cord blood (hUCB) and WJ-derived MSCs regarding neuronal differentiation and cytokine secretion. Materials & methods: MSCs were analyzed by immunoblotting after seven days of differentiation; cytokine protein arrays were used to analyze conditioned medium. Results: Birth weight and blood/anticoagulant ratio influenced MSC yield per unit blood volume, but not maternal and gestational age, delivery mode or fetal gender. Expression of the early neuronal differentiation marker nestin was unaffected by these variables. hUCB- and WJ-derived MSC secrete distinct cytokine profiles. Conclusion: Cell yield is affected by certain donor characteristics. hUCB- and WJ-derived MSCs may serve distinct therapeutic niches.
- 15 June 2016
- Published by Taylor & Francis in Regenerative Medicine
- Vol. 11 (5) , 465-474
Factors Influencing Yield and Neuronal Differentiation of Mesenchymal Stem Cells from Umbilical Cord Blood and Matrix
Aim: Umbilical cord blood and Wharton's jelly (WJ) are potential sources of mesenchymal stem cells (MSCs). We investigated whether harvesting and donor characteristics affected yield and neuronal differentiation, and compared human umbilical cord blood (hUCB) and WJ-derived MSCs regarding neuronal differentiation and cytokine secretion. Materials & methods: MSCs were analyzed by immunoblotting after seven days of differentiation; cytokine protein arrays were used to analyze conditioned medium. Results: Birth weight and blood/anticoagulant ratio influenced MSC yield per unit blood volume, but not maternal and gestational age, delivery mode or fetal gender. Expression of the early neuronal differentiation marker nestin was unaffected by these variables. hUCB- and WJ-derived MSC secrete distinct cytokine profiles. Conclusion: Cell yield is affected by certain donor characteristics. hUCB- and WJ-derived MSCs may serve distinct therapeutic niches.
- Open Access
- 30 April 2016
- Published by Wiley in Case Reports in Transplantation
- Vol. 2016, 1-9
First Autologous Cord Blood Therapy for Pediatric Ischemic Stroke and Cerebral Palsy Caused by Cephalic Molding during Birth: Individual Treatment with Mononuclear Cells
Intracranial laceration due to traumatic birth injury is an extremely rare event affecting approximately one newborn per a population of 4.5 million. However, depending on the mode of injury, the resulting brain damage may lead to lifelong sequelae, for example, cerebral palsy for which there is no cure at present. Here we report a rare case of neonatal arterial ischemic stroke and cerebral palsy caused by fetal traumatic molding and parietal depression of the head during delivery caused by functional cephalopelvic disproportion due to a “long pelvis.” This patient was treated by autologous cord blood mononuclear cells (45.8 mL, cryopreserved, TNC) with a remarkable recovery. Active rehabilitation was provided weekly. Follow-up examinations were at 3, 18, 34, and 57 months. Generous use of neonatal head MRI in case of molding, craniofacial deformity, and a sentinel event during parturition is advocated to enhance diagnosis of neonatal brain damage as a basis for fast and potentially causative treatment modalities including autologous cord blood transplantation in a timely manner.- 30 April 2016
- Published by Wiley in Case Reports in Transplantation
- Vol. 2016, 1-9
Open AccessFirst Autologous Cord Blood Therapy for Pediatric Ischemic Stroke and Cerebral Palsy Caused by Cephalic Molding during Birth: Individual Treatment with Mononuclear Cells
Intracranial laceration due to traumatic birth injury is an extremely rare event affecting approximately one newborn per a population of 4.5 million. However, depending on the mode of injury, the resulting brain damage may lead to lifelong sequelae, for example, cerebral palsy for which there is no cure at present. Here we report a rare case of neonatal arterial ischemic stroke and cerebral palsy caused by fetal traumatic molding and parietal depression of the head during delivery caused by functional cephalopelvic disproportion due to a “long pelvis.” This patient was treated by autologous cord blood mononuclear cells (45.8 mL, cryopreserved, TNC) with a remarkable recovery. Active rehabilitation was provided weekly. Follow-up examinations were at 3, 18, 34, and 57 months. Generous use of neonatal head MRI in case of molding, craniofacial deformity, and a sentinel event during parturition is advocated to enhance diagnosis of neonatal brain damage as a basis for fast and potentially causative treatment modalities including autologous cord blood transplantation in a timely manner.