Margaret P. Martinetti

Objective: The purpose of this paper is to describe a study protocol of a clinical trial exploring the effectiveness of the new mobile application MyDéfi proposing personalized feedback, on both alcohol consumption and quality of life, as well as the blood alcohol exposure biomarker phosphatidylethanol, in university students displaying binge drinking behavior. Methods: This prospective national multicentric randomized, two‐arm (1:1), double‐blind controlled trial will recruit 628 students (aged 18–25 years) with binge drinking behavior. Participants will be randomized in the “intervention” group (personalized feedback) or the “control” group (generic feedback) and will undergo four monthly visits. Monthly dried blood spot sample for measuring phosphatidylethanol concentration and online questionnaires will be collected. Our primary objective is to assess the reduction weekly standard drinks, through self‐report gathered via MyDéfi. Secondary objectives will evaluate the application's impact on the dosage of phosphatidylethanol blood concentration and on quality of life”. Results: Recruitment started in March 2024 and will end in March 2026. Conclusion: This study aims to determine the effectiveness of two versions of the same mobile application (generic vs. personalized feedback) on alcohol consumption in students displaying binge drinking behavior. The effectiveness of the application will be measured, with a secondary objective of quantifying phosphatidylethanol. Our study will open new perspectives on the use of digital interventions for students who do not actively seek treatment. Trial Registration: Trial registration number (NCT06084832), the date of registration (10th October 2023) and when this was done (16th October 2023). https://clinicaltrials.gov/study/NCT06084832

College student-athletes represent a high-risk group for heavy alcohol consumption and negative alcohol-related consequences. Although college drinking correlates with access to low-cost alcohol, no study has examined demand, or the relationship between price and consumption, in student-athletes. Furthermore, the prevalence of anxiety, depression, and drinking to cope motives in student-athletes suggest athlete-specific risks of alcohol consumption that have not yet been examined in conjunction with demand. Therefore, the present study examined gender differences in alcohol demand, alcohol consumption, and anxiety and depressive symptoms in student-athletes (n = 118) and nonathletes (n = 78) at three colleges/universities. Participants completed the Alcohol Purchase Task and measures of alcohol-related behaviors and mental health. Observed demand indices including intensity (i.e., consumption at zero price), O_max (i.e., maximum expenditure), P_max (i.e., price associated with O_max), and breakpoint-1, or BP₁ (i.e., highest price of nonzero consumption) were calculated at the individual level. The rate of change in demand elasticity (i.e., decrease in consumption relative to price increases) was calculated at the group level. Overall, students reported lower alcohol consumption at higher alcohol prices, but men reported higher alcohol consumption and demand intensity than women, student-athletes reported higher O_max than nonathletes, and student-athletes reported lower depressive symptoms than nonathletes. These findings support reducing access to low-cost alcohol in college drinking environments as a harm-reduction strategy, particularly for high-risk student populations, such as men and those involved in athletics. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Background: The aim of the present study was to assess the frequency and clinical correlates of users of an Internet drug forum who changed their alcohol use during the March–May 2020 COVID-19 lockdown in France. Methods: An anonymous Internet-based cross-sectional survey during the COVID-19 lockdown was used via messages on a French Internet drug forum. Participants reported any increase in their alcohol consumption during the lockdown. Alcohol craving and depressive/anxiety symptoms were assessed using the Obsessive and Compulsive Drinking scale (OCDS) and Hospital Anxiety and Depression scale (HADS). Results: Of 1310 respondents, 974 (79% of 1270) participants reported alcohol use before lockdown. During the lockdown, 405 participants (41.6%; IC95 (38.5–44.7)) reported an increase. Odds of an increase in alcohol consumption was higher for those with HADS scores higher than 7 (aOR: 2.19; p = 0.00002), OCDS scores greater than 7 (aOR: 3.50; p < 0.001), and daily psychostimulant use (aOR: 1.85; p = 0.002). Conclusions: Users of an Internet drug forum who reported high levels of depressive symptoms, high levels of alcohol craving, and the use of psychostimulants were more likely to increase alcohol consumption during a COVID-19 lockdown.

Background College students affiliated with fraternity and sorority, or “Greek” life represent a known high-risk group for alcohol consumption and related consequences, but little is known about demand for alcohol in this population. The current study examined behavioral economic demand for alcohol in a sample of Greek life-affiliated undergraduate students using the alcohol purchase task (APT) and a novel variation of the APT that included a fixed-price, nonalcoholic alternative (APT Choice). Methods Participants (n = 229) completed the APT, APT Choice, Alcohol Use Disorders Identification Test (AUDIT), and Daily Drinking Questionnaire (DDQ). Group demand indices were calculated for the entire sample and then separately for participants who met or did not meet the legal drinking age (21+ or underage, respectively). Independent-sample t tests assessed whether there were any significant differences between the two age cohorts in the percent change in each behavioral economic index from the APT to APT Choice. Tests of correlation evaluated the construct validity of the demand indices from both hypothetical purchase tasks. Results Descriptive statistics on alcohol use in this Greek-affiliated sample revealed “hazardous” drinking scores, with AUDIT-C scores exceeding the threshold of alcohol misuse. These measures were significantly correlated with demand indices from both APT conditions, and demand was inversely related to price; however, demand for alcohol was reduced when a nonalcoholic alternative was available. Both age cohorts reported a reduction in BP₁ (highest price of nonzero consumption) and an increase in α (rate of change in elasticity), but these changes were significantly greater among underage participants. Conclusions Although Greek life-affiliated students demonstrate high demand for alcohol, the concurrent availability of a nonalcoholic alternative reduces alcohol demand, particularly for underage students. These findings suggest that nonalcoholic options may enhance the effectiveness of increasing alcohol prices to reduce alcohol consumption among students at higher risk for alcohol use.

Heavy drinking among college students is a public health concern in part due to the accessibility of alcohol and promotions such as "happy hours," which discount the price of alcohol. In addition, consuming alcohol at unregulated off-campus parties may result in greater alcohol consumption, higher blood alcohol concentrations, and increased negative consequences. The purpose of the current study was to assess demand for a refillable red "Solo" cup using a new hypothetical purchase task, the Cup-Price Purchase Task (CPPT). The CPPT asked college student participants to read a description of an off-campus party drinking context and indicate the likelihood of purchasing a refillable cup at prices ranging from $0.00-$60.00. We found that at cup prices of $5.00 or below, the likelihood of purchase was 75% or higher; however, probability of purchase decreased to about 47% at a cup price of $10.00. In addition, several CPPT behavioral economic parameters were positively correlated with the Alcohol Purchase Task (APT) and other alcohol-related measures, providing support for the CPPT's construct validity. Finally, hierarchical regression analyses revealed that maximum expenditure on the CPPT was a unique predictor of both alcohol consumption and alcohol-related consequences, even after controlling for the APT metrics. These findings may inform future studies investigating the behavioral economics of high-risk drinking situations and potential strategies to reduce binge drinking. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Underage drinking is a significant public health concern, specifically among college students. The availability of fake IDs increases risks of college binge drinking as well as sexual victimization, providing a call for research on behavioral correlates. The purpose of the present experiment was to determine how much money an underage college sample (N = 98) at a large Midwestern university would be willing to pay to obtain a fake ID and to identify relations between demand for alcoholic drinks, demand for a fake ID, and adverse consequences of past alcohol consumption as measured by the Brief Young Adult Alcohol Consequences Questionnaire. Hierarchical negative binomial regression suggested demand intensity and Omax for alcoholic drinks as well as Omax for a fake ID were associated with a greater number of negative consequences of past alcohol consumption. The present experiment adds to the surmounting evidence implicating demand for fake IDs on college campuses as a serious public health concern.

Background Studying synaptic plasticity in the rat hippocampus slice is a well‐established way to analyze cellular mechanisms related to learning and memory. Different modes of recording can be used, such as extracellular field EPSP and diverse patch‐clamp methods. However, most studies using these latter methods have been performed only up to the juvenile stage of brain maturation, which is known to terminate during late adolescence/early adulthood. Moreover, several animal models of human diseases have been developed at this late stage of brain development. To study the vulnerability of adolescent rat to the cognitive impairment of alcohol, we developed a model of binge‐like exposure in which ethanol selectively abolishes LFS‐induced, field EPSP LTD in the rat hippocampus slice. Methods In the present study, we sought to use whole‐cell patch‐clamp recording in the voltage‐clamp mode to further investigate the mechanisms involved in the abolition of LFS‐induced LTD in our model of binge‐like exposure in adolescent rat hippocampus slices. In addition, we investigated LFS‐induced NMDAR‐LTD and mGluR‐LTD at different ages and changed several parameters to improve the recordings. Results Using patch‐clamp recording, LFS‐induced NMDAR‐LTD and mGluR‐LTD could be measured until 4 weeks of age, but not in older animals. Similarly, chemical mGluR‐LTD as well as a combined LFS‐LTD involving both NMDAR and mGluR were not measured in older animals. The absence of LFS‐LTD was not due to the loss of a diffusible intracellular agent nor the voltage mode of recording or intracellular blockade of either sodium or potassium currents. In contrast to voltage‐clamp recordings, LFS‐induced LTD tested with field recordings was measured at all ages and the effects of ethanol were visible in all cases. Conclusion We concluded that whole‐cell patch‐clamp recordings are not suitable for studying synaptic LFS‐induced LTD in rats older than 4 weeks of age and therefore, cannot be used to explore electrophysiological disturbances, such as those induced by alcohol binge‐drinking during adolescence, which constitutes a late period of brain maturation.