JCJames A. Clay
James A. Clay
*This is an algorithmically generated author record based on publicly available information.
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
James A. Clay has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Anna S. Seydel
Department of General Surgery, Marshfield Clinic, Marshfield, WI, USA
1 shared publication - Christopher B. Crawford
Ascens St Vincent Carmel Hosp, Dept Surg, Carmel, IN USA
1 shared publication - Jessica A. Wernberg
Department of General Surgery, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA
1 shared publication
Latest Publications
- Open Access
- 1 January 2016
- Published by Wiley in International Journal of Breast Cancer
- Vol. 2016, 1-7
Surgical Site Infections in Breast Surgery: The Use of Preoperative Antibiotics for Elective, Nonreconstructive Procedures
Background. Antibiotic prophylaxis for surgical site infections (SSIs) for breast surgery is widespread, but the benefit in clean surgical cases is not well defined.Methods. A retrospective analysis of 855 patients undergoing elective, nonreconstructive breast operations was performed, with 401 patients receiving no antibiotics and 454 patients receiving a single dose of preoperative antibiotic.Results. Administration of a preoperative antibiotic did not decrease the SSI rate. In this community-based study, antibiotic use practices varied considerably by surgeon. In univariate analyses, SSI rates appeared to increase with prophylactic antibiotic use (12% SSI with antibiotics versus 4% without,), likely because the use of underdosed antibiotics was associated with higher rates of SSI (13.2% SSI with cefazolin 1 gram,, and 15.4% SSI with clindamycin 300 mg or less,). Methicillin-resistantStaphylococcus aureuswas the most common isolate from SSI cultures, 31.8% (7 of 22). In multivariable analyses, increased risk of SSI was associated with BMI > 25 kg/m2(OR: 1.08, 95% CI: 1.04–1.11,).Conclusion. The administration of a single dose of preoperative antibiotic did not decrease the rate of SSI in this large series of patients undergoing clean breast operations. BMI >25 kg/m2and the use of an inadequate dose of antibiotics for prophylaxis may increase risk of SSI.- 1 January 2016
- Published by Wiley in International Journal of Breast Cancer
- Vol. 2016, 1-7
Open AccessSurgical Site Infections in Breast Surgery: The Use of Preoperative Antibiotics for Elective, Nonreconstructive Procedures
Background. Antibiotic prophylaxis for surgical site infections (SSIs) for breast surgery is widespread, but the benefit in clean surgical cases is not well defined.Methods. A retrospective analysis of 855 patients undergoing elective, nonreconstructive breast operations was performed, with 401 patients receiving no antibiotics and 454 patients receiving a single dose of preoperative antibiotic.Results. Administration of a preoperative antibiotic did not decrease the SSI rate. In this community-based study, antibiotic use practices varied considerably by surgeon. In univariate analyses, SSI rates appeared to increase with prophylactic antibiotic use (12% SSI with antibiotics versus 4% without,), likely because the use of underdosed antibiotics was associated with higher rates of SSI (13.2% SSI with cefazolin 1 gram,, and 15.4% SSI with clindamycin 300 mg or less,). Methicillin-resistantStaphylococcus aureuswas the most common isolate from SSI cultures, 31.8% (7 of 22). In multivariable analyses, increased risk of SSI was associated with BMI > 25 kg/m2(OR: 1.08, 95% CI: 1.04–1.11,).Conclusion. The administration of a single dose of preoperative antibiotic did not decrease the rate of SSI in this large series of patients undergoing clean breast operations. BMI >25 kg/m2and the use of an inadequate dose of antibiotics for prophylaxis may increase risk of SSI.