Nauman Ahmed

Introduction: Adverse drug reactions resulting from the use of a medicinal product and were harmful or unpleasant reaction. Pharmacovigilance is related pharmaceuticals product after marketing and associated with collection, detection, assessment, monitoring and prevention of adverse effects. The aim of study is to recognize the awareness of pharmacists regarding pharmacovigilance and adverse drug reactions reporting. Methodology: Descriptive cross-sectional study conducted to 237 pharmacists working in Khartoum’s locality pharmacies from August 2019 to March 2020 selected by simple randomization. The data were collected by face to face interview using self-administrated Questionnaire and analyzed by SPSS version 23. Results: 57.4% from the total sample size never seen adverse drug reactions reporting form, 76.4% never receive training on how to report it and only 10.5% from the pharmacists in the study report it to pharmacovigilance center. 79% from pharmacists in the study were not aware about existence of pharmacovigilance program in Sudan. 51.5 % from pharmacists have good attitude about adverse drug reactions and pharmacovigilance in Sudan while 48.5% had poor attitude. Difficulty in communicating with pharmacovigilance centre in Sudan and how to write the report were the factors discourage pharmacists from reporting of adverse drug reactions. Conclusion: Community pharmacists have insufficient knowledge about the concept of pharmacovigilance and spontaneous ADRs reporting while they had positive attitudes toward pharmacovigilance, despite their little experience with ADRs reporting, this can be strengthened by educational trainings and workshops. Peer Review History: Received: 4 September 2021; Revised: 9 October; Accepted: 29 October, Available online: 15 November 2021 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Neelam H. Zaidi, Fiji National University, Fiji, drneelamzaidi@gmail.com Dr. U. S. Mahadeva Rao, Universiti Sultan Zainal Abidin, Terengganu Malaysia, raousm@gmail.com Dr. Hayriye Eda Şatana Kara, Gazi University, Turkey, eda@gazi.edu.tr Dr. Andrzej Szymański, Poznan University of Technology, Poland, andrzej.szymanski@put.poznan.pl Similar Articles: AWARENESS OF PHARMACISTS TOWARDS ASPARTAME SIDE EFFECTS IN KHARTOUM CITY, SUDAN ASSESSMENT OF THE ROLE OF COMMUNITY PHARMACISTS IN MANAGEMENT OF HIV-POSITIVE INDIVIDUALS IN THE SOUTHERN REGION OF NIGERIA

A 42-year-old male with non-ischaemic dilated cardiomyopathy, sinus rhythm, LBBB morphology (QRS duration 150ms), New York Heart Association class III heart failure symptoms and recurrent syncope with non-sustained ventricular tachycardia was referred for cardiac resynchronisation therapy with defibrillator (CRT-D) implantation. Implantation of the LV lead proved difficult due to inability to cannulate the coronary sinus (CS) ostium despite the use of multiple catheters and delayed acquisition coronary angiography (Supplementary material online, VideosS1 and S2). Computed tomography revealed a severe ostial stenosis (Panel A, arrow) and no evidence of a persistent left superior vena cava. Eventually, during a second procedure, an anomalous branch of the CS which drained into the high RA was cannulated with a Boston Scientific diagnostic fixed Josephson curve quadripolar catheter (Boston Scientific,...

Background: Implantable loop recorders (ILR) allow prolonged cardiac rhythm monitoring and improved diagnostic yield in syncope patients. Predictive factors for pacemaker (PM) implantation in the ILR population with unexplained syncope have not been adequately investigated. In this single center, retrospective, observational study we investigated factors that predict PM implantation in this population.Methods: We retrospectively analyzed our ILR database of patients aged over 18 years who underwent ILR implantation for unexplained syncope between January 2009 and June 2013. Patient case notes were examined for demographics, history, electrocardiogram (ECG) abnormalities, investigations, and events during follow‐up. The primary end‐point was the detection of a symptomatic or asymptomatic bradycardia requiring PM implantation.Results: During a period of 4.5 years, 200 patients were implanted with ILR for unexplained syncope, of who n = 33 (16.5%) had clinically significant bradycardia requiring PM implantation. After multivariable analysis, history of injury secondary to syncope was found to be the strongest independent predictor for PM implantation (odds ratio [OR]:9.1; P < 0.001; 95% confidence interval [CI]: (3.26–26.81). Other significant predictors included female sex, PR interval > 200msec, and age >75 years. In patients without conduction abnormalities on the ECG, history of injury secondary to syncope was found to be the strongest independent predictor for PM implantation (OR: 8.16; P = 0.00027; 95% [CI]: (2.67–26.27).Conclusions: A history of injury secondary to syncope and female sex were independent predictive factors for bradycardia necessitating PM implantation in patients receiving an ILR for syncope with or without ECG conduction abnormalities.

Introduction Cardiac resynchronisation therapy (CRT) is an established treatment for symptomatic heart failure. Most centres mandate an overnight hospital stay to monitor for any potential complications, mainly LV lead displacement. This increases pressure on beds and the costs of implantation. Due to increasing experience and better equipment, the LV lead displacement rate is currently low, with shorter procedures and reduced contrast use, which negates the need for overnight stays. The aim of this study is to assess feasibility, safety and patient acceptability of day case CRT implantation. Methods We identified patients who underwent elective CRT implantation from September 2013 to March 2014 by two operators. These were done as planned day cases or planned overnight stays depending on operator preference. Patient demographics, procedure details, and complications were recorded for both groups. All patients were surveyed by telephone for their satisfaction with the procedure, hospital stay and discharge process. Results We identified 53 patients during the study period of which 35 (66%) patients were planned as day case procedures. Out of these 35 patients, 22 (63%) were discharged the same day. 5 (14%) patients were kept overnight due to clinical reasons: 3 small haematomas and 1 coronary dissection for observation and 1 patient who felt generally unwell post procedure. All 5 patients were discharged the next day. The remaining 8 (23%) patients had to stay overnight due to non-clinical reasons: n = 5 due lack of home support or transport issues and n = 3 due late finish of implant procedure. Patients who were discharged the same day had no complications after discharge or during the first 6 weeks. Among the 18 (34%) planned overnight stay patients, 2 patients had RV lead displacements detected at 6 weeks follow-up that were not identified on next morning predischarge assessment or pacing check. All patients were contacted by telephone and 48 (90%) patients responded to the survey. The responses of patients who were initially planned as day case procedure but had to stay overnight (n = 13) were excluded to eliminate bias. Results are shown in the Table 1 below. Results of the patient survey Conclusion Day case CRT implantation is feasible, safe and is preferred by the majority of patients particularly those who have received a day case implant. Overnight night stay post implantation appears unnecessary. Unplanned overnight stays for non-clinical reasons can be avoided with better planning of cath lab schedules and logistics.

An early repolarization (ER) pattern on electrocardiography was historically considered a benign finding; however, this finding in the inferior and lateral leads has recently been associated with idiopathic ventricular fibrillation (VF). Here we describe a case of a 29‐year‐old man with an ER pattern, who experienced recurrent implantable cardioverter‐defibrillator (ICD) shocks for ventricular tachycardia (VT) and VF. An ICD interrogation demonstrated how VF and VT were repeatedly initiated by closely coupled premature ventricular beats.