Boningari Thirupathi

Highly dispersed copper iodide on activated carbon (CuI/C) solid catalyst has been investigated for the Paal–Knorr condensation of γ-diketones with aliphatic, aromatic and heterocyclic amines under solvent-free conditions; which lead to the formation of N- substituted pyrrole derivatives in excellent yields. This simple experimental procedure combined with easy recovery and reusability of the catalyst is expected to contribute to the progression of a clean and ecofriendly strategy for the synthesis of N-substituted pyrrole derivatives.

A novel copper (II) hydrotalcite catalyst has been investigated for its use in the cascade synthesis of β-hydroxy triazoles. It is found to be a dynamic catalyst for regioselective organic synthesis in water. The copper (II) hydrotalcite catalyst, in various Cu : Al molar ratios, was prepared by adopting a coprecipitation method and characterized using different techniques. The three component (epoxides, sodium azide and terminal alkynes) reactions under investigation were performed in water at ambient temperature without any additives. The formation of 2-azido alcohol, generated in situ, was observed to be the key step in the [3+2] cycloaddition of the click reaction. The optimized reaction procedures described herein are not only regioenriched and high yielding but also eco-friendly.

Oximes, allylic, aliphatic, aromatic, cyclic, acyclic, and hetero alcohols are silylated in short reaction times with good yields in the midst of a catalytic amount of sulfated zirconia solid acid catalyst and trimethylsilyl cyanide under nonbasic, solvent-free, and ambient temperature conditions. Selectivity toward O-silyl ether rather than N-silyl ether has been observed. This simple experimental procedure, combined with easy recovery and reusability of the catalyst, is expected to contribute to the development of a clean and environmentally friendly strategy for the synthesis of O-silyl ethers.