Siraj Ul Islam

Objective: To estimate the frequency of thrombocytopenia among patients with vivax-positive malaria. Study Design: Cross Sectional Study. Setting: Department of General Medicine Hayatabad Medical Complex Peshawar. Period: May 2022 to November 2022. Material & Methods: Total 140 cohort were observed in this study. Patients were taken as sample according to inclusion and exclusion criteria as per operational definition after the patients' written informed consent. Sociodemographic data was collected on a predesigned questionnaire. History such as febrile illnesses and blood dyscrasias and basic studies and peripheral blood smears were obtained. Results: The results of the study showed the sample has mean age 36 years with SD ± 3.72, of which 70% were men while 30% were women. Thrombocytopenia was observed in 68% of patients. Conclusion: In conclusion, the estimated frequency of thrombocytopenia in vivax malaria was found to be 68%.

Quantification of climate change impacts on the thermal regimes of rivers in British Columbia (BC) is crucial given their importance to aquatic ecosystems. Using the Air2Stream model, we investigate the impact of both air temperature and streamflow changes on river water temperatures from 1950 to 2015 across BC’s 234,000 km²Fraser River Basin (FRB). Model results show the FRB’s summer water temperatures rose by nearly 1.0 °C during 1950–2015 with 0.47 °C spread across 17 river sites. For most of these sites, such increases in average summer water temperature have doubled the number of days exceeding 20 °C, the water temperature that, if exceeded, potentially increases the physiological stress of salmon during migration. Furthermore, river sites, especially those in the upper and middle FRB, show significant associations between Pacific Ocean teleconnections and regional water temperatures. A multivariate linear regression analysis reveals that air temperature primarily controls simulated water temperatures in the FRB by capturing ~80% of its explained variance with secondary impacts through river discharge. Given such increases in river water temperature, salmon returning to spawn in the Fraser River and its tributaries are facing continued and increasing physical challenges now and potentially into the future.

In response to ongoing and future-projected global warming, mid-latitude, nival river basins are expected to transition from a snowmelt-dominated flow regime to a nival–pluvial one with an earlier spring freshet of reduced magnitude. There is, however, a rich variation in responses that depends on factors such as the topographic complexity of the basin and the strength of maritime influences. We illustrate the potential effects of a strong maritime influence by studying future changes in cold season flow variability in the Fraser River Basin (FRB) of British Columbia, a large extratropical watershed extending from the Rocky Mountains to the Pacific Coast. We use a process-based hydrological model driven by an ensemble of 21 statistically downscaled simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5), following the Representative Concentration Pathway 8.5 (RCP 8.5). Warming under RCP 8.5 leads to reduced winter snowfall, shortening the average snow accumulation season by about one-third. Despite this, large increases in cold season rainfall lead to unprecedented cold season peak flows and increased overall runoff variability in the VIC simulations. Increased cold season rainfall is shown to be the dominant climatic driver in the Coast Mountains, contributing 60 % to mean cold season runoff changes in the 2080s. Cold season runoff at the outlet of the basin increases by 70 % by the 2080s, and its interannual variability more than doubles when compared to the 1990s, suggesting substantial challenges for operational flow forecasting in the region. Furthermore, almost half of the basin (45 %) transitions from a snow-dominated runoff regime in the 1990s to a primarily rain-dominated regime in the 2080s, according to a snowmelt pulse detection algorithm. While these projections are consistent with the anticipated transition from a nival to a nival–pluvial hydrologic regime, the marked increase in FRB cold season runoff is likely linked to more frequent landfalling atmospheric rivers in the region projected in the CMIP5 models, providing insights for other maritime-influenced extratropical basins.

Canada's Fraser River Basin (FRB), the largest watershed in the province of British Columbia, supplies vital freshwater resources and is the world's most productive salmon river system. We evaluate projected changes in the FRB's runoff variability and regime transitions using the Variable Infiltration Capacity (VIC) hydrological model. The VIC model is driven by an ensemble of 21 statistically downscaled simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5), for a 150-year time period (1950–2099) over which greenhouse gas concentrations follow the CMIP5 Representative Concentration Pathway (RCP) 8.5. Using mean and standard deviation (variability) metrics, we emphasize projected hydroclimatological changes in the cold season (October to March) over different sub-basins and geoclimatic regions of the FRB. Warming consistent with the RCP8.5 scenario would lead to increased precipitation input to the basin with higher interannual variability and considerably reduced winter snowfall shortening the average snow accumulation season by about 38 %. Such changes in temperature and precipitation will increase cold season runoff variability leading to higher cold season peak flows. In the lower Fraser River, cold season runoff will increase by 70 % and its interannual variability will double compared to the 1990s, presenting substantial challenges for operational flow forecasting by the end of this century. Cold season peak flows will increase substantially, particularly in the Coast Mountains, where the peak flow magnitudes will rise by 60 %. These projected changes are consistent with a basin-wide transition from a snow-melt driven flow regime to one that more closely resembles a rainfall driven regime. This study provides key information relating to projected hydroclimate variability across the FRB, describes potential impacts on its water resources, and assesses the implications for future extreme hydrological events.