Dequn Wu

This review summarizes recent advances in smart wound dressings for chronic wound management, including exudate management, real-time monitoring, broad-spectrum antibacterial therapy, inflammation regulation, and stimuli-responsive drug delivery.

With the surging demand for personalized medicine and point‐of‐care testing (POCT) in the field of healthcare, there is an urgent need for highly sensitive and low‐cost methods to detect biomarkers in biofluids such as blood, sweat, and saliva. While biosensors serve as a popular method to detect various biomarkers based on fragile biological receptors such as antibodies and enzymes, these natural recognition elements often suffer from environmental instability and high production costs. Consequently, molecularly imprinted polymers (MIPs), named as artificial antibody, demonstrate tremendous potential in electrochemical sensing due to their superior performance including high sensitivity, strong selectivity, customizability and low‐cost. However, the successful translation of these artificial receptors from laboratory settings into complex real‐world clinical biofluids remains significantly limited by matrix effects and severe biofouling. Based on recent achievements and challenges in MIP electrochemical sensors, this paper systematically reviews the evolution of MIP‐based electrochemical sensors, from traditional bulk polymerization to advanced Nano‐MIP strategies. Also, the recent progress in functional materials and the applications of the sensors across various bio‐fluids are comprehensively summarized. Furthermore, the specific requirements of different biofluid matrices and the challenges of anti‐biofouling are reviewed. Finally, prospects for AI‐assisted screening of MIP material and data analysis are discussed to provide theoretical insights for the development of next‐generation intelligent biosensing systems. Overall, this review aims to provide guidance for the optimization of the sensitivity, selectivity and future application of MIP electrochemical sensors as smart medical platforms for POCT.

A two-step modification strategy, including epoxide crosslinking and iron ion chelation post-crosslinking, is established to fabricate elastic protein-based hydrogel fibers for soft electronic devices.

The rapid progress in electronics has exacerbated electromagnetic pollution, escalating the demand for electromagnetic interference (EMI) shielding materials. Whereas the abandonment of conventional nonbiodegradable EMI materials further provoked environmental pollution. Consequently, there is a growing emphasis on the biodegradability of EMI materials, in addition to qualities such as strong absorption, lightweight, flexibility, and breathability. In this study, biodegradable ultrafine fibrous EMI shielding mats were developed from epoxy-modified corn protein zein (ZE) with single- or double-layer coatings of polypyrrole (PPy) and silver (Ag). The epoxy modification endowed the base ZE fibers with adequate mechanical properties and morphological stability in wet conditions, ensuring high air permeability. The PPy/ZE mats achieved an EMI shielding effectiveness (SE) of 26.69 dB within the 8.2 to 12.4 GHz frequency range, which was further boosted to 86.00 dB by the Ag/PPy/ZE mats. Even after 5000 bends, 86.5% and 79.3% of the SE values could be retained. The Ag/PPy/ZE mats demonstrated antibacterial properties and adjustable joule heating performance. Biodegradation was evident after 40 days of soil burial, characterized by near-linear weight loss and alterations in mechanical properties. This study positions the Ag/PPy/ZE mats as a promising option for short-term EMI shielding in electronic devices or biomedical applications, both in vitro and in vivo, thereby stimulating the advancement of biobased EMI shielding materials.

Janus adhesive hydrogels exhibit broad prospects in biomedical fields such as tissue repair, anti‐adhesion, hemostasis, and human activity sensing. However, a simple fabrication process for Janus hydrogels remains lacking, which limits their clinical translation. To address the above issue, this study proposes an innovative fabrication strategy based on solvent evaporation‐induced interfacial self‐assembly: solvent evaporation drives the spontaneous aggregation of polyvinyl alcohol (PVA) at the water–air interface; then, combined with free radical polymerization of acrylamide (AM)/isocyanoethyl methacrylate‐arginine (IEM‐Arg) and freeze‐thaw treatment, Janus hydrogels are constructed in one step. There is a significant difference in adhesive strength between the two sides of this Janus hydrogel; after adding polydopamine‐coated reduced graphene oxide (rGO@PDA), the adhesive strength of the bottom side is ten times that of the top side. In this study, the mechanism underlying the asymmetric adhesion of the hydrogel is investigated using techniques such as X‐ray photoelectron spectroscopy (XPS) and X‐ray diffraction (XRD). In terms of biomedical applications, when this Janus hydrogel is used as a biomedical patch in an abdominal wall defect model, the results showed that it can effectively inhibit the formation of tissue adhesions and promote soft tissue regeneration.

Synergistic management of light, heat, water, and salt through a biomimetic gradient structure enables highly efficient and stable brine evaporation.