Shuo Bai

Conductive hydrogels, owing to their flexibility, high biocompatibility, tissue-mimetic properties, and electrical responsiveness, hold broad application prospects in fields such as flexible biosensing, wearable electronics, and health monitoring. However, constructing continuous and stable conductive pathways while maintaining biocompatibility and mechanical stability remains a key challenge in the design of such materials. In this study, we combined template casting with a chemical welding strategy to fabricate patterned AgNWs-GelMA conductive hydrogels. The results indicate that chemical welding effectively improves the connection quality at AgNWs intersections, increasing the electrical conductivity of the samples by at least 67% under identical conditions. Furthermore, the conductive hydrogel exhibited good biocompatibility. Flexible sensors constructed from this material generated stable electrical responses to external stimuli, such as pressure and joint motion. Under a constant cyclic pressure of 0.2 N, the sensors exhibited a rapid total response and recovery time of 200 ms, demonstrating their potential for flexible biosensing applications, particularly under conditions of small deformation.

Peptide-based materials offer unique advantages for constructing supramolecular chiral systems due to their bioactivity and intrinsic chirality. However, precise control over the expression, transfer, and amplification of chirality from the molecular to supramolecular level remains a significant challenge in developing high-performance chiral materials. In this study, we demonstrate that achiral anions regulate hydrogen bonding interactions in dipeptide assembly, leading to the formation of chiral microrolls composed of two-dimensional nanosheets. These microrolls exhibit pH-dependent chiroptical switching and intense circularly polarized luminescence with a dissymmetry factor (|g_lum|) of 0.062. Furthermore, the chiral ultraviolet emission from these microrolls enables enantioselective polymerization of diacetylene, offering potential applications in chiral catalysis. These findings enhance our understanding of chirality modulation in biomolecular assemblies and provide a pathway toward the development of high-performance chiral biomaterials.

Artificial neural pathway (ANP) implants hold transformative potential for empowering individuals with disabilities, which has recently revolutionized the clinical treatment of spinal cord injury through epidural electrical stimulation (EES). Classical EES operates with a pre-set program and needs manual modification, consuming both manpower and time. Although existed studies proposed kinematic image processing to configurate EES or a brain-spine interface to control motions automatically, prompt tuning on motor modulation in an open environment is still inaccessible. Here, we show a wireless self-fine-tuning ANP implant to establish a rapid self-feedback mechanism appropriate for free activities to achieve precise motor modulation by EES. The fine-tuning pathway was attached to the writing pathway using a wireless implanted bidirectional neural interface featuring compact size, low input noise, and high energy efficiency, with different functionalities including reading, writing, and bidirectional control. The sciatic neural signals are fed into the pathway as rapid feedback for self tuning. Without manual interventions, we restored gaits of hindlegs in paralyzed animals with EES by a self-fine-tuning, near-real-time, and close-loop motor modulation mechanism.

As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies, human disease therapy has witnessed a great lea

Glioblastoma multiforme (GBM) is one of the most lethal malignant brain tumors in the central nervous system. Patients face many challenges after surgery, including tumor recurrence, intracranial pressure increase due to cavitation, and limitations associated with immediate postoperative oral chemotherapy. Here an injected peptide gel with in situ immunostimulatory functions is developed to coordinate the regulation of glutamine metabolism and chemodynamic therapy for overcoming these postoperative obstacles. The methodology entails crafting injectable gel scaffolds with short peptide molecules, incorporating the glutaminase inhibitor CB‐839 and copper peptide self‐assembled particles (Cu‐His NPs) renowned for their chemodynamic therapy (CDT) efficacy. By fine‐tuning glutamic acid production via metabolic pathways, this system not only heightens the therapeutic prowess of copper peptide particles in CDT but also escalates intracellular oxidative stress. This dual mechanism culminates in augmented immunogenic cell death within glioblastoma multiforme cells and improves a conducive immune microenvironment. Based on the concept of metabolic reprogramming, this treatment strategy has great potential to significantly reduce GBM tumor recurrence and prolong median survival in murine models.