Liliana Carina Baptista

Statins’ effects on cardiorespiratory fitness (CRF) and their interaction with exercise training remain unclear in older adults with dyslipidemia. This cohort study enrolled nine hundred and eighty-one older adults with dyslipidemia who underwent one of three interventions: (i) multicomponent exercise training (MEX; n = 298; 74% females), (ii) daily statin monotherapy (ST; n = 178; 65% females), or (iii) combined treatment with statins and multicomponent exercise training (STMEX; n = 505; 79% females). CRF, functional status, and lipid profile were assessed at baseline and after 24 months. After follow-up, statin therapy reduced CRF by 4% in women (p < 0.001), but not in men. The statin groups also showed reduced upper- and lower-limb strength in both sexes. Exercise alone significantly improved CRF (women: 27% vs. men: 21%, p < 0.001) and functional status, regardless of sex. The combined treatment significantly increased women’s CRF, whereas men showed an attenuated CRF benefit (women: 27% vs. men: 1%, p < 0.001). Our findings suggest sex-specific patterns in the effects of statin therapy on CRF in older adults with dyslipidemia. Statin therapy was associated with lower CRF over time in women, but not in men, whereas multicomponent exercise training may reverse these effects.

Background: Long-haul travel and jet lag can disrupt athletes’ circadian, physiological, and performance systems, potentially impairing competition outcomes. This review aimed to study the effects of long-haul travel on athletes’ health and performance, differentiate travel fatigue from jet lag, and review mitigation strategies. Methods: A systematic narrative review was conducted following PRISMA 2020 guidelines. PubMed, Scopus, and Web of Science were searched for studies on jet lag, travel fatigue, and long-haul travel in athletes. Eligibility included studies reporting physiological, hemodynamic, or performance outcomes in athletes of any level and sex. Data were extracted on travel characteristics, interventions, physiological and performance markers, and risk of bias. Results: Overall, 284 records were identified, with 89 studies included. Travel directions were equally distributed between eastward and westward journeys, crossing 1–12 time zones. Interventions to mitigate travel effects were reported in 17 studies, primarily melatonin, caffeine, and light exposure. Common physiological changes included sleep disturbances (n = 36), body temperature alterations (n = 18), blood pressure changes, hormonal shifts (n = 9), heart rate variability (n = 4), and immune alterations (n = 4). Travel effects comprised fatigue (n = 25), sleep changes (n = 21), decreased physical performance (n = 18), mood changes (n = 15), and cognitive impairments (n = 9). Physical performance outcomes included anaerobic power (n = 18), strength (n = 14), velocity (n = 12), aerobic capacity (n = 10), coordination (n = 8), and reaction time (n = 7). Risk of bias was low in 49%, moderate in 17%, and high in 34% of studies. Conclusions: Long-haul travel negatively affects multiple physiological and performance domains in athletes, including sleep, hormonal balance, autonomic function, and physical performance. The magnitude of these effects seems to be influenced by travel direction, number of time zones crossed, and individual susceptibility. Eastward travel is generally associated with stronger circadian disruption and impaired aerobic capacity, coordination, and technical performance, whereas westward travel often induces greater fatigue and adversely affects team-sport outcomes. Monitoring key markers such as heart rate variability, sleep, and cortisol, combined with personalized strategies including circadian management, sleep hygiene, nutrition, recovery interventions, and training load adjustments, is essential to mitigate travel-related impairments and optimize performance.

The present study investigated variance in overall quality of life in relation to a broad spectrum of correlates, including sociodemographic characteristic

Objectives: Our objective was to evaluate the acute effect of L-leucine supplementation and high-intensity sprint exercise on appetite-controlling neuropeptides and their association with the subjective perception of appetite (SPA), satiety (SPS), food intake, and inflammatory response in overweight participants. Methods: In a double-masked, randomized, counterbalanced, and crossover design, 12 sedentary overweight adult men performed four experiments: (1) exercise and L-leucine (EX-Leu), (2) exercise and placebo (EX-PLA), (3) L-leucine without exercise (SED-Leu), and (4) placebo without exercise (SED-PLA). The supplementation consisted of three daily doses of 70 mg/kg body weight of L-leucine or placebo (on the day of exercise and one day after). During the experiments, we recorded the food intake, SPA, and SPS, and evaluated the neuropeptides (GLP-1, PYY, CCK, and ghrelin) and cytokines (IL1-beta, IL-6, IL-10, and TNF-α) in peripheral blood. The acute exercise trial consisted of four sets of 30 sec cycle ergometer sprint exercises. Results: EX-Leu, EX-PLA, and SED-Leu decreased SPA, compared to SED-PLA; only EX-PLA improved SPS; EX-PLA and EX-Leu reduced food intake. GLP-1 decreased in the EX-PLA trial compared to SED-Leu. IL-6 and IL1-β levels increased in the EX-Leu trial compared to SED-PLA. An anti-inflammatory profile was identified in the EX-PLA trial compared to the other trials. Both neuropeptides (increased) and cytokines (a pro-inflammatory profile) were associated with changes in SPA, SPS, and food intake. Conclusions: The acute inflammatory balance induced by EX-Leu seems to improve appetite control. Sprint exercise had a consistent acute anorexic effect, while isolated L-leucine decreased SPA, but their impact on SPS and food intake is not clear (FAPESP grants: 2020/09936-2 and 2021/03601-1).

The study investigated the prevalence of students meeting moderate-to-vigorous physical activity (MVPA) recommendations and factors associated with MVPA during the first year of the COVID-19 pandemic. A cross-sectional study was conducted with 4059 university students (2200 females [F]) during the lockdown using an electronic form. PA was assessed using the short version of the International Physical Activity Questionnaire (IPAQ-SF). Independent variables included sociodemographic characteristics, knowledge to perform PA, pre-pandemic PA, sedentary behavior (SB), and health self-reports related to the COVID-19 pandemic. Overall, 56% of students met MVPA recommendations (males [M]: 57.7%, F: 54.3%; χ² = 4.703, p = 0.030). Knowledge to perform PA (M: OR = 3.012, 95% CI: 2.413–3.759; F: OR = 2.948, 95% CI: 2.444–3.556) and being physically active before the pandemic (M: OR = 2.651, 95% CI: 2.060–3.412; F: OR = 1.459, 95% CI: 1.079–1.974) increased the likelihood that students attained the MVPA recommendations. In contrast, longer daily exposure to SB was negatively associated with MVPA in both sexes. In this context, the present findings reinforce the relevance of universities as strategic settings for the promotion of PA in middle-income countries, where social and economic vulnerabilities may exacerbate the long-term consequences of physical inactivity.

Background: Exercise-induced bronchoconstriction (EIB) is common in athletes, being more frequent in outdoor endurance-based/long-distance sports. We followed a World-Class marathon paddler’s season with recurrent episodes of EIB, which intensified during cold exposure workouts. This unique immunophenotype profile during the season and its variations were reflected in acute and chronic inflammatory markers. Methods: A longitudinal case study was conducted with blood sampling obtained from a single paddler after overnight fasting at three timepoints: T1 (beginning of season, after 15-day rest period), T2 (post-Winter National Championship), and T3 (post-Summer National Championship). Complete blood counts and lymphocyte immunophenotyping were performed using automated hematology analysis and multiparametric flow cytometry. Results: The total numbers of leukocytes (T1: 6.3; T2: 5.0; T3: 5.5 × 10⁹/L), neutrophils (3.1; 2.5; 2.8 × 10⁹/L), and lymphocytes (2.4; 1.8; 2.2 × 10⁹/L) declined between T1 and T2, followed by a partial recovery at T3. In contrast, monocyte counts exhibited the reverse pattern (0.41; 0.62; 0.31 × 10⁹/L). The two T cell subsets (αβ and γδ) remained relatively stable, showing only minor seasonal fluctuations. CD19+ B cells, initially at very low levels, increased steadily as the season progressed (0.05; 0.07; 0.16 × 10⁹/L). During T2, the proportion of memory lymphocytes (CD45RO+) rose, while naive cells (CD45RA+) declined; this trend was subsequently inverted at M3. Although the CD4+/CD8+ ratio varied over time, it consistently stayed below the normal reference range established for healthy controls (0.50; 0.83; 0.60 for T1, T2, and T3, respectively). Conclusions: The immune assessment of the World-Class marathon paddler revealed transient immunosuppression early in the season, marked by reduced neutrophils, a low CD4+/CD8+ ratio, and diminished CD19+ lymphocytes. Over time, immune parameters showed signs of recovery, indicating a temporary imbalance that did not impair the athlete’s physical performance. Conclusions: This case study of an elite marathon kayaker revealed transient immune fluctuations across a competitive season, including early immunosuppression (low neutrophils, CD4+/CD8+ ratio 0.50, and minimal CD19+ B cells) followed by partial recovery mid- and late-season. Despite persistently inverted CD4+/CD8+ ratios suggesting chronic immune dysregulation, the athlete maintained competitive performance, highlighting the temporary nature of these changes and emphasizing that regular immune monitoring can help optimize health and performance in elite athletes.

Introduction: Capoeira has expanded its relevance within formal education, not only in Brazil but also internationally. Objective: This study aimed to analyze and summarize the scientific evidence on Capoeira in the school context, particularly regarding its didactic and pedagogical aspects. Methodology: A qualitative literature review was conducted in the Web of Science, PubMed, and Dialnet databases, using descriptors in Portuguese, Spanish, and English. Inclusion criteria comprised articles published in the last 11 years, available in full text, and aligned with the integration of Capoeira in the school context. Results: A total of 120 articles were identified: Web of Science (n=82), Dialnet (n=22), and PubMed (n=16). The selected articles were categorized as follows: 1) Experimental studies (n=1); 2) Training actions in Capoeira (n=3); 3) Theoretical studies (n=3); 4) Pedagogical units of Capoeira in Physical Education (n=6); and 5) Extracurricular interventions with Capoeira (n=7). Discussion: The analysis revealed that Capoeira has been incorporated as a pedagogical tool fostering cultural, cognitive, affective, and motor learning. However, many studies show theoretical and methodological weaknesses, including the absence of systematized didactic proposals and the lack of articulation with legal frameworks and curricular guidelines in Physical Education, which limits its consolidation in formal education. Conclusion: The findings point to a common pedagogical and didactic conception that understands Capoeira as an educational bodily practice, articulating motor, expressive, cognitive, and social dimensions, associated with meaningful learning and recognition of cultural diversity. Future studies should explore its pedagogical potential with stronger theoretical and methodological foundations, thus supporting its consolidation in school Physical Education.

This chapter explores the transformative potential of physical education (PE) when integrated into a transdisciplinary and physically active learning (PAL) framework. By moving beyond the traditional confines of the gym and classroom, we examine how PE can serve as a core component of holistic education. The chapter delves into the theoretical underpinnings of transdisciplinary and active learning, highlighting their alignment with the goals of PE. It will provide practical examples and strategies for implementing transdisciplinary PE programs, emphasizing collaboration with other subject areas and the creation of authentic learning experiences. The chapter will also discuss the role of PE in fostering critical thinking, problem-solving, and creativity, while promoting physical literacy and well-being. Ultimately, this chapter aims to inspire educators to reimagine PE as a dynamic and essential component of a comprehensive curriculum.

Background/Objectives: The associations between low birth weight (LBW) and the aggregation of metabolic risk factors (MRF) in youth remain ambiguous. Thus, this study analysed the interrelationship among MRF, LBW, and behavioural factors in adolescents. Methods: The sample of the present cross-sectional study comprised 491 youth (229 males, 262 females) aged 14–17 years. Height, weight, and BMI were assessed. Cardiorespiratory fitness (CRF) was measured using the PACER test. Physical activity (PA) was evaluated using a 3-day diary. A MRF risk score was calculated using the Z-scores of the five MRF criteria (HDL-C, triglycerides, BP, insulin, and blood glucose). Results: The average values for height, weight, and systolic and diastolic BP were significantly higher in males (p < 0.01); in contrast, females exhibited higher HDL cholesterol and insulin levels (p < 0.01). Boys revealed higher levels of PA (p < 0.01), and they achieved better CRF scores than girls (p < 0.01). BMI emerged as a significant predictor of clustered metabolic risk for both males (β = 0.26; 95% CI, 0.16–0.36) and females (β = 0.02; 95% CI, 0.14–0.30); additionally, the results indicated that more physically active girls had a notably lower metabolic risk (β = −0.01; 95% CI, −0.10–−0.01) than their male peers. Conclusions: LBW was found to be independently correlated with the aggregated MRF (β = −0.01; 95% CI, −0.01–0.00) among boys aged 14–17 years.