Changqun Cai

A novel and environmentally benign electrochemical method for the direct C2─H amination of benzoxazoles has been developed. This protocol employs N , N ‐dimethylformamide not only as a solvent but also as the amino source, undergoing anodic decarbonylation to generate a dimethylamino radical. The reaction proceeds under exogenous oxidant‐ and transition metal‐free conditions, utilizing inexpensive iodine as a redox mediator and a catalytic amount of 4‐ tert ‐butylbenzoic acid as an additive. A broad range of substituted benzoxazoles is tolerated, affording the corresponding 2‐(dimethylamino)benzoxazole derivatives in moderate to good yields. The transformation shows excellent functional group compatibility and is scalable to gram‐level. Mechanistic investigations, including radical trapping experiments and cyclic voltammetry, support a radical pathway involving the key formation of a dimethylamino radical intermediate.

A ZIF-8 dual-functional platform enables biochemical-reagent-free visual HBV detection. By combining molecular imprinting with intrinsic peroxidase-like activity, the sensor generates colorimetric signals upon target recognition. Smartphone-integrated RGB analysis achieves a 2.22 pM detection limit within 15 minutes at ultralow cost, offering point-of-care testing potential for resource-limited settings.

Tumor cell identification is of crucial significance for cancer diagnosis, and has been focused on cell-surface proteins. In this work, we demonstrated that high specificity can be achieved by integrating cell-surface protein and dual-miRNAs for sensor design. The DNA quadrilateral sensor was designed by assembling an aptamer, two miRNA complementary sequences with multiple complementary strands. The aptamer was specific for the membrane protein of tumor cell. The two miRNAs complementary sequences were employed to build an AND logical signal output in response to intracellular dual miRNAs. Only when membrane protein and dual-miRNAs were present sitmultaneously, the sensor could be operated in cells with high specificity. By imaging various types of cancer cell with differential expression of membrane protein and dual-miRNAs, our sensor exhibited excellent accuracy imaging analysis of target tumor cells.

A localized catalytic hairpin assembly-based DNA tetrahedral sensor was proposed to achieve rapid and sensitive imaging of miRNA-10b.

A novel, transition metal- and oxidant-free electrochemical method has been developed for the synthesis of sulfenamides with high atom economy (84.1%). This strategy employs commercially available N,N-dimethylformamide (DMF) and its derivatives as liquid, safe, and convenient surrogates for low-boiling amines, thereby overcoming the handling challenges associated with gaseous amines such as dimethylamine. Under constant current conditions, a variety of thiols and disulfides undergo efficient cross-coupling with formamides to afford the corresponding sulfenamides in good to excellent yields. The reaction features a broad substrate scope, excellent functional group tolerance, mild conditions (50 °C, air atmosphere), and simple workup without the need for column chromatography in many cases. Gram-scale synthesis and preliminary mechanistic studies are also presented, highlighting the practical utility and potential reaction pathway of this sustainable electrocatalytic protocol.

This work presents an electrocatalytic strategy for safe and efficient phosphinamide synthesis using liquid formamides, avoiding volatile low-boiling amines. This metal- and oxidant-free method offers a versatile platform for green synthesis.

Tunable electrochemical oxidation of bisphosphines enables selective synthesis of bidentate phosphine monooxides (BPMOs) and dioxides (BPDOs) by adjusting current, a metal-and-oxidant-free method using DMF as oxygen source for ligand synthesis.

The need for rapid, sensitive, and selective detection of viral pathogens has never been more apparent. Molecularly imprinted polymers have emerged as robust synthetic receptors that rival biological antibodies in...