Chunyi Hao

Subsequently to the publication of the above paper, the authors contacted the Editorial Office to explain that, for the Transwell migration and invasion assay experiments shown in Fig. 4 on p. 573, the data panel for the ‘94T778 / Lenti‑shTYMS‑1’ experiment shown in Fig. 4A was selected incorrectly. The authors have re‑examined their original data, and realize how this error occurred. The revised (and corrected) version of Fig. 4 shown on the next page. The authors sincerely apologize for the error introduced during the preparation of this figure, although they confirm that this did not grossly affect either the results or the conclusions reported in this study. They also thank the Editor of Oncology Reports for granting them the opportunity to publish a Corrigendum, and apologize to the readership for any inconvenience caused. [Oncology Reports 44: 565‑576, 2020; DOI: 10.3892/or.2020.7635]

Pancreatic ductal adenocarcinoma (PDAC) presents significant clinical challenges owing to its dense stroma and complex tumor microenvironment (TME). In this study, large-scale single-cell transcriptomics and spatial transcriptomics (ST) were integrated to dissect the heterogeneity of fibroblasts and their crosstalk with epithelial cells, with a focus on key ligand-receptor interactions. Eight distinct fibroblast subpopulations were identified, among which extracellular matrix (ECM)-remodeling fibroblasts were particularly enriched in tumor tissues and associated with poor prognosis. ECM-remodeling fibroblasts were located at the terminal stage of the fibroblast pseudotime trajectory, and SOX11 was identified as a key transcription factor in this subpopulation. Further analyses revealed that ECM-remodeling fibroblasts can interact with epithelial cells through the POSTN-ITGAV/ITGB5 ligand-receptor axis, a critical pathway that promotes tumor progression. Clinical analyses demonstrated a strong correlation between POSTN expression and poor prognosis in patients with PDAC. Mechanistically, POSTN interacts with integrin ITGAV/ITGB5 on tumor cells, activating the PI3K/AKT/β-catenin pathway and promoting epithelial-mesenchymal transition (EMT) phenotype. Pharmacological inhibition of the POSTN-integrin axis partially reversed these malignant traits, highlighting its potential as a therapeutic target. This study provides new insights into fibroblast heterogeneity and its role in PDAC progression, emphasizing the POSTN-ITGAV/ITGB5 axis as a promising target for therapeutic interventions.

Background: Retroperitoneal liposarcoma (RLPS) is a rare malignancy with no effective treatment beyond surgical intervention. Identifying novel therapeutic targets and prognostic markers is critical to improving outcomes. Fibroblast growth factor receptor substrate 2 (FRS2), located near MDM2 on chromosome 12q13-15, has a biological role and prognostic value in liposarcoma, which remain to be fully explored.

Background Liposarcomas are mesenchymal malignant tumors characterized by varying degrees of adipocytic differentiation that comprises approximately 20% of soft tissue sarcomas. Despite advancements in this field, there remains a need for a comprehensive understanding of the mechanisms, diagnosis, and treatment of liposarcomas. Currently, there is a lack of bibliometric surveys on the development trajectory of liposarcomas treatment, research hotspots, and author and team collaboration. Methods In this study, we obtained publications from the Web of Science database from 2004 to 2023, with a specific focus on the treatment of liposarcomas. By utilizing bibliometric methods, the data were processed to facilitate visual analysis of various aspects, including authors, countries, institutions, cocitations, keywords, references, and gene characteristics. Results The number of publications on liposarcomas treatment has increased over the past two decades, from 39 in 2004 to 232 in 2023, with the United States of America contributing the most publications. Among the institutions, the Memorial Sloan Kettering Cancer Center had the highest volume of 87 publications. Notably, Alessandro Gronchi published 63 articles on the treatment of liposarcomas in the last 20 years. Cancers is the journal with the highest number of 57 publications. High-frequency keywords in these publications included “soft tissue sarcoma”, “liposarcoma”, “retroperitoneal sarcoma”, “surgery”, “dedifferentiated liposarcoma”, “trabectedin” and “radiotherapy”. Recent trends, identified through strong citation bursts from 2020 to 2023, include next-generation sequencing, radiotherapy, and patient-derived cell lines. High-frequency genes in the liposarcomas treatment field include TP53, MDM2, CDK4, DDIT3, and CD274. Conclusions The treatment of liposarcomas has garnered increasing attention worldwide in the last 20 years. The treatment approach has shifted from surgical resection to multidisciplinary therapy. The molecular and biological characteristics of different tumor subtypes have attracted more research attention, providing an important reference for the choice of treatment. The findings of this study contribute to providing a comprehensive understanding of liposarcomas treatment among researchers. Moreover, they offer valuable perspectives that can guide future research.

Background: The tumor immune microenvironment, including neutrophils and tertiary lymphoid structures (TLSs), is pivotal for HCC prognosis assessment. Tumor‐associated neutrophils exhibit plasticity, adopting either an antitumorigenic N1 (MPO+ CD206−) or a pro‐tumorigenic N2 (MPO+ CD206+) phenotype. We explored the prognostic value of neutrophil plasticity and TLS maturity in HCC in both tumor and peritumoral tissues and addressed their interaction.Methods: A retrospective cohort of 79 HCC patients who underwent radical resection from 2015 to 2018 was analyzed, with complete clinical characteristics and survival data of more than 5 years. Multiplex immunohistochemistry identified N1/N2 neutrophils and TLS maturity. Survival differences and correlations with clinical features were assessed.Results: HCC patients were divided into high‐ and low‐level groups on the basis of the N1 and N2 classifications of neutrophils, revealing a positive correlation with prognosis in tumor tissues and a negative one in peritumoral tissues. TLS maturity stages were associated with prognosis, with a higher proportion of secondary TLS (SFL‐TLS) in peritumoral tissues correlating positively with survival. Further analysis of the correlation between neutrophils and TLSs revealed that most neutrophils infiltrated outside of the TLS in the peritumoral tissues of patients with HCC, and the proportions of SFL‐TLSs and N1 cells in the peritumoral tissue were negatively correlated and positively correlated with survival. Both univariate and multivariate analyses revealed that the N1/N2 ratio in peritumoral tissues was an independent prognostic predictor of HCC.Conclusions: The N1/N2 ratio of neutrophils and the proportion of SFL‐TLS are considered important prognostic indicators that may reflect the immune microenvironment of HCC patients.