Diana Redwood

Supplemental Table 1. Associations of continuous (m2CLR) 16S microbiome with CRC-specific mortality (N=581)

Supplemental Figure 5 shows the m2CLR distribution (boxplots) of two MetaCyc pathways of interest stratified by population group.

Supplemental Figure 1 displays relative abundance of eight different phyla stratified by tissue macrodissection status, either macrodissection or scraping the entire slide.

Supplemental Figure 2 shows the distribution (boxplots) of an alpha diversity metric, Shannon entropy, stratified by CRC-specific mortality status.

Supplemental Table 4. Associations of Fusobacteriota phylum with CRC-specific mortality stratified by right & left-sided tumor location, overall & by population group

Supplemental Figure 4 shows the m2CLR distribution (boxplots) of the phylum Fusobacteriota, the genera Fusobacterium and Leptotrichia, stratified by population group. Due to high percentages of zeros the median of all boxplots is zero.

Supplemental Table 2. Associations of 16S microbiome positivity with CRC-specific mortality among those microsatellite instability low or microsatellite stable (N=415)

Supplemental Table 3. Associations of continuous (m2CLR) 16S Fusobacteriota phylum & genera with CRC-specific mortality stratified by population group

Supplemental Figure 3 shows two components of beta diversity, PCoA 1 and PCoA 2, as well as ellipses to compare if beta diversity using weighted unifrac was different by CRC-specific mortality status.