Lei Yu

Integrating the “magic methyl” effect and deuterium kinetic isotope effect, trideuteromethyl (CD ₃ ) modification is a robust strategy for pharmaceutical development. Accordingly, the development of cost‐effective and practical methods to install CD ₃ moieties into drug‐like molecules is highly desirable. Herein, we develop a reusable heterogeneous Pd‐catalyzed trideuteromethylation of arylboron esters, with D ₂ O serving as the sole deuterium source. Methylthianthrenium salts (TT‐Me) act as key precursors, undergoing facile H/D exchange to in situ produce CD ₃ synthons for efficient one‐pot cross‐coupling with arylboron esters. This protocol features outstanding functional group compatibility and an extraordinarily broad substrate applicability. It enables the trideuteromethylation of diverse biologically relevant scaffolds, as well as the modular two‐step synthesis of aryl‐CD ₃ skeletons starting from commercially available aryl chlorides, phenols, anilines, and benzoic acids. It also facilely affords ¹³ CH ₃ / ¹³ CD ₃ dual‐labeled analogs for pharmaceutical and analytical use. Combined with C─H borylation, this one‐pot platform achieves direct trideuteromethylation of inert aryl C─H bonds, allowing divergent installation of two site‐specific CD ₃ moieties into lidocaine isotopologues. Mechanistic investigations reveal a surface‐mediated heterogeneous pathway, where K ₂ CO ₃ dually activates TT‐Me and arylboron esters. This work offers a practical, scalable and sustainable route for constructing aryl–CD ₃ isotopic architectures.

Integrating the “magic methyl” effect and deuterium kinetic isotope effect, trideuteromethyl (CD ₃ ) modification is a robust strategy for pharmaceutical development. Accordingly, the development of cost‐effective and practical methods to install CD ₃ moieties into drug‐like molecules is highly desirable. Herein, we develop a reusable heterogeneous Pd‐catalyzed trideuteromethylation of arylboron esters, with D ₂ O serving as the sole deuterium source. Methylthianthrenium salts (TT‐Me) act as key precursors, undergoing facile H/D exchange to in situ produce CD ₃ synthons for efficient one‐pot cross‐coupling with arylboron esters. This protocol features outstanding functional group compatibility and an extraordinarily broad substrate applicability. It enables the trideuteromethylation of diverse biologically relevant scaffolds, as well as the modular two‐step synthesis of aryl‐CD ₃ skeletons starting from commercially available aryl chlorides, phenols, anilines, and benzoic acids. It also facilely affords ¹³ CH ₃ / ¹³ CD ₃ dual‐labeled analogs for pharmaceutical and analytical use. Combined with C─H borylation, this one‐pot platform achieves direct trideuteromethylation of inert aryl C─H bonds, allowing divergent installation of two site‐specific CD ₃ moieties into lidocaine isotopologues. Mechanistic investigations reveal a surface‐mediated heterogeneous pathway, where K ₂ CO ₃ dually activates TT‐Me and arylboron esters. This work offers a practical, scalable and sustainable route for constructing aryl–CD ₃ isotopic architectures.

The development of cost-effective, high-performance electrocatalysts for the alkaline hydrogen evolution reaction is imperative for sustainable hydrogen production via water electrolysis. However, the intrinsically sluggish reaction kinetics and insufficient exposed active sites of transition metal sulfides remain critical bottlenecks. Herein, we report the facile hydrothermal synthesis of binder-free, three-dimensional NiCo2S4/MoS2 heterostructured nanoflakes directly grown on nickel foam as a highly efficient electrocatalyst for alkaline hydrogen evolution. Benefiting from the synergistic effects between NiCo2S4 and MoS2, which provide abundant active edge sites, enhanced electrical conductivity, and reinforced structural stability, the as-prepared NiCo2S4/MoS2 electrode exhibits excellent activity in alkaline media, requiring an ultralow overpotential of only 112 mV to achieve a current density of 10 mA cm–2. Moreover, the electrode demonstrates remarkable long-term durability. The superior hydrogen evolution performance originates from the rational integration of NiCo2S4 and MoS2 within the unique heterostructure, offering a promising strategy for designing other robust transition metal sulfide-based electrocatalysts.

Non‐petroleum synthetic processes are developed not merely for environmental sustainability, but more crucially for securing supply stability and industrial chain safety. This work innovatively establishes a universal synthesis platform based on shared petroleum and non‐petroleum intermediates. It maintains the consistent high quality of petroleum‐derived products and allows direct feedstock switching to non‐petroleum sources without modifying downstream equipment during petroleum shortages. Guided by element transfer reaction (ETR) theory and verified with adiponitrile, epichlorohydrin, and phenol, this strategy remarkably enhances industrial chain resilience, economic efficiency, and long‐term security.

CeO ₂ weakens the B acid strength by Ce ⁴⁺ –O–W ⁶⁺ linkages and enhances the reducibility of V ⁵⁺ species via Ce ⁴⁺ –O–V ⁵⁺ bonds. TiO ₂ -NP{101} exhibits the strongest interaction with V ⁵⁺ , W ⁶⁺ and Ce ⁴⁺ ions, leading to the superior SCR performance.

The deoximation reaction is a crucial transformation in carbonyl compound synthesis and regeneration. It exhibits great potential for industrial application and is, therefore, a major research focus for industrial organic synthesis. This Synopsis summarizes systematic advances in selenium- and tellurium-catalyzed oxidative deoximation. These protocols feature mild and green conditions, recyclable high-TON catalysts, and substrate compatibility. Beyond technical progress, this work provides profound insights into organic synthesis, with mechanistic diversity further advancing the development of catalytic strategies.