Adam Sierakowski

Surgery for nail bed injuries in children is common. One of the key surgical decisions is whether to replace the nail plate following nail bed repair. The aim of this RCT was to assess the clinical effectiveness and cost-effectiveness of nail bed repair with fingernail replacement/substitution compared with repair without fingernail replacement. A two-arm 1 : 1 parallel-group open multicentre superiority RCT was performed across 20 secondary-care hospitals in the UK. The co-primary outcomes were surgical-site infection at around 7 days after surgery and cosmetic appearance summary score at a minimum of 4 months. Some 451 children presenting with a suspected nail bed injury were recruited between July 2018 and July 2019; 224 were allocated to the nail-discarded arm, and 227 to the nail-replaced arm. There was no difference in the number of surgical-site infections at around 7 days between the two interventions or in cosmetic appearance. The mean total healthcare cost over the 4 months after surgery was €84 (95 per cent c.i. 34 to 140) lower for the nail-discarded arm than the nail-replaced arm (P < 0.001). After nail bed repair, discarding the fingernail was associated with similar rates of infection and cosmesis ratings as replacement of the finger nail, but was cost saving. Registration number: ISRCTN44551796 (http://www.controlled-trials.com).

Objective: We report the case of a 77-year-old man who presented with a long-standing, large swelling of the left hypothenar eminence. This was associated with recent-onset paresthesia and numbness of the ring and little fingers. Magnetic resonance imaging demonstrated a cystic lesion that occupied almost the entire bulk of the hypothenar eminence. Methods: Surgical exploration revealed a 7-cm, encapsulated, yellow-brown cyst, around which were stretched the superficial sensory branches of the ulnar nerve. The hypothenar musculature lay flattened against the deep border of the mass. Results: The cyst was removed and Guyon's canal was released. Histologic examination confirmed a large cyst containing proteinaceous debris and blood breakdown products. It might have resulted from hemorrhage into a long-standing ganglion. Removal of the cyst led to full resolution of the patient's symptoms. Conclusions: This represents an unusual cause of ulnar tunnel syndrome. It is rare to encounter such a large cyst in the hand and interesting in the sense that the resulting symptoms were relatively mild and took many years to develop.

We report on a case of metastatic Merkel cell carcinoma in a 74-year-old patient with positive staining for thyroid transcription factor-1. This represents a new immunohistochemical staining pattern for Merkel cell carcinoma and has implications regarding the accurate diagnosis of this tumor type.