Michael J. Wright
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Michael J. Wright has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Alan McNally
Institute of Microbiology and Infection, School of Infection, Inflammation, and Immunology, College of Medicine and Health, University of Birmingham
1 shared publication - Claire Jenkins
Gastrointestinal Bacteria Reference Unit, UK Health Security Agency , London NW9 5HT
1 shared publication - David Robert Greig
Gastrointestinal Bacteria Reference Unit, UK Health Security Agency, London, UK
1 shared publication Ebony Hunter
National Infection Services, Public Health England, 61 Colindale Avenue, London NW9 5HT, UK
1 shared publicationTimothy J. Dallman
National Infection Services, Public Health England, 61 Colindale Avenue, London NW9 5HT, UK
1 shared publicationUlf Schaefer
National Infection Services, Public Health England, 61 Colindale Avenue, London NW9 5HT, UK
1 shared publication
Latest Publications
- 1 April 2019
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 68 (4) , 538-548
Identification and typing of Yersinia enterocolitica and Yersinia pseudotuberculosis isolated from human clinical specimens in England between 2004 and 2018
Purpose and Methodology . Epidemiological and microbiological data on Yersinia enterocolitica (n=699) and Yersinia pseudotuberculosis (n=35) isolated from human clinical specimens in England between April 2004 and March 2018 were reviewed. Traditional biochemical species identification and serological typing results were compared with species identifications and serotypes derived from whole-genome sequencing (WGS) data for a sub-set of these isolates (n=179). Results. Most Y. enterocolitica isolates were from faecal specimens (74.4%) from adults (80.7%) and 50.7 % of isolates were from male patients. Most Y. pseudotuberculosis isolates were from blood cultures (68.6%) from adults (91%) and 60.0 % of isolates were from male patients. All sequenced isolates of Y. enterocolitica (n=158) and Y. pseudotuberculosis (n=21), as well as isolates belonging to other Yersinia species (n=21), were correctly identified from genomic data using a kmer-based identification approach. Traditional phenotypic serotyping typed 82/158 and 12/21 isolates of Y. enterocolitica and Y. pseudotuberculosis, respectively, while 118/158 and 21/21 isolates of Y. enterocolitica and Y. pseudotuberculosis, respectively, were typed by the genome-derived serotyping method. In addition, WGS data provided a multi-locus sequence type profile and virulence gene profile for all isolates. Conclusion. The use of WGS for typing Y. enterocolitica and Y. pseudotuberculosis at Public Health England will facilitate the monitoring of animal-to-human transmission of these important foodborne pathogens in the UK and improve public health surveillance of the pathogenic lineages.
- 1 April 2019
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 68 (4) , 538-548
Identification and typing of Yersinia enterocolitica and Yersinia pseudotuberculosis isolated from human clinical specimens in England between 2004 and 2018
Purpose and Methodology . Epidemiological and microbiological data on Yersinia enterocolitica (n=699) and Yersinia pseudotuberculosis (n=35) isolated from human clinical specimens in England between April 2004 and March 2018 were reviewed. Traditional biochemical species identification and serological typing results were compared with species identifications and serotypes derived from whole-genome sequencing (WGS) data for a sub-set of these isolates (n=179). Results. Most Y. enterocolitica isolates were from faecal specimens (74.4%) from adults (80.7%) and 50.7 % of isolates were from male patients. Most Y. pseudotuberculosis isolates were from blood cultures (68.6%) from adults (91%) and 60.0 % of isolates were from male patients. All sequenced isolates of Y. enterocolitica (n=158) and Y. pseudotuberculosis (n=21), as well as isolates belonging to other Yersinia species (n=21), were correctly identified from genomic data using a kmer-based identification approach. Traditional phenotypic serotyping typed 82/158 and 12/21 isolates of Y. enterocolitica and Y. pseudotuberculosis, respectively, while 118/158 and 21/21 isolates of Y. enterocolitica and Y. pseudotuberculosis, respectively, were typed by the genome-derived serotyping method. In addition, WGS data provided a multi-locus sequence type profile and virulence gene profile for all isolates. Conclusion. The use of WGS for typing Y. enterocolitica and Y. pseudotuberculosis at Public Health England will facilitate the monitoring of animal-to-human transmission of these important foodborne pathogens in the UK and improve public health surveillance of the pathogenic lineages.