Hakan Kilci

Objective: COVID-19, caused by coronavirus SARS-CoV-2, is a pandemic viral respiratory infection in which venous and arterial thromboembolic events are often observed. This study aimed to investigate the relationship between atherogenic indices and cardiovascular thromboembolic events in patients with COVID-19 pneumonia. Material and Method: In this retrospective study, a total of 805 inpatients (median age 63 [IQR: 52-74] years; 45.1% female) who were diagnosed with COVID-19 pneumonia between March 2020 and December 2020 were evaluated. Patients were divided into two groups based on cardiovascular thromboembolic events with cardiovascular thromboembolic events (n=96) and without-cardiovascular thromboembolic events (n=709). All clinical and demographic data and laboratory results were analyzed. Atherogenic Index of Plasma (AIP (log10 (triglyceride/ HDL)), Atherogenic Coefficient (AC (HDL/ non-HDL)), Risk Index of Castelli-I (CRI-I (Total cholesterol/ HDL)), and Risk Index of Castelli-II (CRI-II (LDL/ HDL)) were calculated. Results: Atherogenic Coefficient, CRI-I, and CRI-II values were significantly higher in the cardiovascular thromboembolic event group (p=0.001, p=0.001, p=0.007, respectively). AIP values were higher in the cardiovascular thromboembolic events group but were not statistically significant (p=0.051). In the cardiovascular thromboembolic events group, HDL values were found to be significantly lower (p=0.001), but CRP and D-dimer values were found to be significantly higher (p

Coronary bifurcation lesions,POT-side-POT,kissing balloon inflation,single- stent strategy

Aim: To investigate the relationship between post-myocardial infarction (MI) left ventricular ejection fraction (LVEF) and fibrosis marker HE-4 in primarily revascularized patients with ST-segment ...

Background: Re-proximal optimizing technique (rePOT) (POT, side branch inflation and final POT) is a new provisional coronary bifurcation stenting technique which has better results in bench tests in comparison with kissing balloon inflation (KBI) techique. A clinical study showed that rePOT had beneficial effects in terms of strut malapposition, side branch obstruction and stent geometry. But it has not been compared with KBI technique especially in patients with ST segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (p-PCI). Purpose: The aim of our study is to compare the new rePOT technique with a known and widely used provisional stenting technique in a real-world special patient population in terms of clinical and technical aspects Methods: 51 patients with STEMI who underwent p-PCI and needed provisional side branch stenting were enrolled in a tertiary center. Patients who needed “two stent strategy” at the beginning of procedure were deferred. Results: Results were shown in Table 1. In-hospital death, contrast induced acute kidney injury, side branch dissection, need for side branch stenting and acute stent thrombosis were lower in rePOT group but there was no statistically significance. Table 1 rePOT group (n=23) KBI group (n=28) p value Age 51.6±11.7 51.2±9.4 0.87 Male gender 18 (78.3%) 24 (85.7%) 0.16 Diabetes Mellitus 3 (13%) 6 (21.4%) 0.43 Hypertension 5 (21.7%) 5 (17.9%) 0.73 Ejection fraction 46.8±10.6 44.8±8.4 0.43 Killip class>2 1 (4.3%) 4 (14.3%) 0.47 Stent type (DES) 21 (91.3%) 23 (82.1%) 0.34 Side branch dissection 3 (13%) 8 (28.6) 0.18 Side branch stenting 3 (13%) 6 (21.4%) 0.43 In-hospital death 2 (8.7%) 3 (10.7%) 0.81 CI-AKI 3 (13%) 6 (21.4%) 0.43 Acute stent thrombosis 0 2 (7.1%) 0.19 DES: Drug eluting stent; CI-AKI: contrast induced acute kidney injury. Conclusion: To the best of our knowledge this is the first study which compares the new rePOT technique with KBI in patients with STEMI who underwent p-PCI and needed provisional coronary bifurcation stenting. Although results are similiar in terms of clinical and technical aspects, rePOT may be a useful and user-friendly technique in such a complex and emergent procedure. Acknowledgement/Funding: None

It is established that hyperglycemia directly effects the platelet functions and fibrin structure. In this study, we aimed to investigate the predictive value of hyperglycemia on thrombus burden in nondiabetic patients with ST-segment elevation myocardial infarction (STEMI) who underwent to primer percutaneous coronary intervention (PPCI). We enrolled 619 nondiabetic patients with STEMI who received PPCI. Patients were divided two groups according to thrombus burden. Stress hyperglycemia was determined as blood glucose concentration more than 180 mg/dl and angiographic coronary thrombus burden was scored based on thrombolysis in myocardial infarction thrombus grades. Patients with thrombus grades 4 were defined as large thrombus burden (LTB), patients with thrombus burden less than thrombus grades 4 were defined as small thrombus burden. A total of 68 (11.0%) STEMI patients had stress hyperglycemia, while 223 (36.0%) patients had LTB. Sex, the prevalence of hypertension, smoking, and dyslipidemia were not different between the thrombus burden groups (P > 0.05 for all parameters). Compared with the patients with small thrombus burden, the patients with LTB were had significantly higher admission blood glucose concentrations (135 ± 39.1 mg/dl vs. 145.9 ± 43.1, P = 0.002, respectively). The multivariate logistic regression analysis demonstrated that stress hyperglycemia is an independent predictor of LTB (odds ratio: 3.025, confidence interval 1.200–7.622, P = 0.019). Admission hyperglycemia is associated with the LTB which cause adverse cardiac outcomes. Hyperglycemia may play a role on thrombus development.