Dennis P. Carmody

Objetivos este estudo de caso-controle comparou os níveis de estresse e carga alostática (CA) entre mulheres mexicanas nos EUA ( n = 19) e no México ( n = 40). Método medidas de estresse incluíram a Escala de Estresse Percebido (EEP) e a Escala de Estresse Social das Mulheres Hispânicas (EESMH). Uma medida composta por 8 indicadores de CA (pressão arterial sistólica e diastólica, índice de massa corporal (IMC), relação cintura-quadril, colesterol total, hemoglobina glicada (hemoglobina A1C), triglicerídeos e proteína C-reativa) foi calculada. Resultados não houve diferenças significativas entre os grupos na CA entre mulheres mexicanas imigrantes e não imigrantes ( t = 1,55, p = 0,126). Uma análise fatorial de componentes principais foi realizada nos 8 indicadores de CA; uma solução de 2 fatores explicou 57% da variância. As diferenças entre grupo nos dois fatores CA foram analisadas usando MANOVA. O IMC e a relação cintura-quadril foram menores, mas a pressão arterial e os triglicerídeos foram maiores no grupo dos EUA e foram mediados pelo tempo nos EUA. O maior estresse de aculturação foi significativamente relacionado ao aumento da relação cintura-quadril ( r = 0,57, p = 0,02). Considerações finais os resultados sugerem que algumas medidas de CA aumentam com o tempo nos EUA e o estresse de aculturação pode ser um fator significativo.

The purpose of this study was to examine pathways through which childhood abuse increases the risk of cervical cancer, including smoking, stress, risky sexual behavior, and not having a Papanicolaou (Pap) test. This is a descriptive, correlational study. The sample included 410 women, recruited from a large, multisite women's health center that serves low-income communities in New Jersey. Data were analyzed using path models and conditional regression analysis. Overall, 15% and 12% of the women in the study reported history of physical and sexual childhood abuse, respectively. There was a significant association between child abuse history and failure to receive a Pap test (χ2 = 5.34, p = 0.021). History of childhood abuse was associated with 44% lower odds of having a Pap test. The findings indicate a significant association between child abuse history and cervical cancer risk (χ2 = 7.65, p = 0.006, Cramer's V = 0.138). History of childhood abuse was associated with 96% higher odds of being at risk of cervical cancer. Both physical and sexual abuses were associated with higher levels of smoking, risky sexual behavior, perceived stress, and cervical cancer risk. In the conditional regression analysis, the effect of risky sexual behavior on the likelihood of cervical cancer risk showed an increased risk with higher risky sexual behavior scores only for those with a history of childhood abuse. Childhood abuse increases the risk of cervical cancer in adulthood, through failure to receive a Pap test and higher levels of smoking, perceived stress, and most importantly, risky sexual behavior. More importantly, the combination of childhood abuse and risky sexual behavior plays a greater role in increasing cervical cancer risk.

Approach behavior, defined as differences in behavior to an incentive event and anger at its removal, was assessed during contingency learning in 87 5‐month olds was related to maternal ratings of mastery behaviors at 2 years. Mothers reported on infants' concurrent temperament, as well as the occurrence of anger and tantrums, and their own anger at 12 months. Approach behavior was expected to predict persistence with objects and persistent motor behavior, but not negative reactions to failure. Negative reactions to failure were expected to be mediated by a distress‐prone temperament. The moderating effect of maternal anger on these relations was also explored using conditional process regression models. Controlling for soothability, early approach behavior predicted toddlers' persistence, especially gross motor persistence, moderated by maternal anger. With more maternal anger, approach behavior and toddler's persistence were more strongly related. Distress to limits, infant anger at 12 months, and maternal anger were significantly correlated, but only infant anger was related to negative reactions to failure. Prior to 6 months, goal‐directed behavior is related to later behavioral persistence, but maternal responses to child anger are an important contributor to this relation and by 12 months, infant anger directly predicts mastery frustration at 2 years.

Objectives. We examined the prevalence and correlates of human papillomavirus (HPV) vaccine initiation among adolescents in low-income, urban areas.Methods. The study consisted of electronic health record data on HPV vaccination for 3180 adolescents (aged 10–20 years) at a multisite community health center in 2011.Results. Only 27% initiated the HPV vaccine. The adjusted odds ratio (AOR) of HPV vaccination was lower among older adolescents (AOR = 0.552; 95% confidence interval [CI] = 0.424, 0.718) and those seen by nonpediatric health care providers (HCPs; AOR = 0.311; 95% CI = 0.222, 0.435), and higher among non-English speakers (AOR = 1.409; 95% CI = 1.134, 1.751) and those seen at 2 site locations (AOR = 1.890; 95% CI = 1.547, 2.311). Insurance status was significant only among female and Hispanic adolescents. Language was not a predictor among Hispanic adolescents. Across all analyses, the interaction of age and HCP specialty was associated with HPV vaccination. Dramatically lower HPV vaccination rates were found among older adolescents seen by nonpediatric HCPs (3%–5%) than among other adolescents (23%–45%).Conclusions. Improving HPV vaccination initiation in low-income urban areas is critical to reducing disparities in cervical and other HPV-related cancer, especially among Black, Hispanic, and low-income populations.

Systematic reviews are carried out to provide an answer to a clinical question based on all available evidence (published and unpublished), to critically appraise the quality of studies, and account for and explain variations between the results of studies. The Joanna Briggs Institute specializes in providing methodological guidance for the conduct of systematic reviews and has developed methods and guidance for reviewers conducting systematic reviews of studies of diagnostic test accuracy. Diagnostic tests are used to identify the presence or absence of a condition for the purpose of developing an appropriate treatment plan. Owing to demands for improvements in speed, cost, ease of performance, patient safety, and accuracy, new diagnostic tests are continuously developed, and there are often several tests available for the diagnosis of a particular condition. In order to provide the evidence necessary for clinicians and other healthcare professionals to make informed decisions regarding the optimum test to use, primary studies need to be carried out on the accuracy of diagnostic tests and the results of these studies synthesized through systematic review. The Joanna Briggs Institute and its international collaboration have updated, revised, and developed new guidance for systematic reviews, including systematic reviews of diagnostic test accuracy. This methodological article summarizes that guidance and provides detailed advice on the effective conduct of systematic reviews of diagnostic test accuracy.

Human papillomavirus (HPV) vaccination continues to lag behind other adolescent vaccines, especially in areas with pervasive disparities in HPV-related cancers. The purpose of this study was to examine HPV vaccine completion and dosing intervals among low-income adolescents in urban areas. The study included electronic health record data on HPV vaccination for 872 adolescents who received at least one dose of the HPV vaccine. Only 28.4 % completed the 3-dose series. For the whole sample, HPV vaccine completion was higher for non-English speakers and among adolescents seen at Newark-South and East Orange sites. Completion was higher among non-English speaking female and Hispanic adolescents, females seen in Newark-South and East Orange sites, and insured Black adolescents. Completion was also dramatically lower among non-English speaking Black adolescents seen at Newark-North, Irvington, and Orange sites (12.5 %) compared to other Black adolescents (22.0–44.4 %). The mean dosing intervals were 5.5 months (SD = 4.6) between dose 1 and 2 and 10 months (SD = 6.1) between dose 1 and 3. Longer durations between vaccine doses were found among uninsured adolescents and those seen at Newark-North, Irvington, and Orange sites. Non-English speakers had longer duration between dose 1 and 3. Further, durations between dose 1 and 3 were dramatically longer among insured adolescents seen at Newark-North, Irvington, and Orange locations for the whole sample (M = 11.70; SD = 7.12) and among Hispanic adolescents (M = 13.45; SD = 8.54). Understanding how the study predictors facilitate or impede HPV vaccination is critical to reducing disparities in cervical and other HPV-related cancer, especially among Black, Hispanic, and low-income populations.