Qiang Zeng
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Qiang Zeng has a total of 32 co-authors. Here are the top co-authors by number of shared publications:
Feina Shi
Department of Neurosurgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
5 shared publicationsFei Dong
Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
3 shared publications- Feina Shi
Department of Neurology, Sir Run Run Shaw Hospital of Zhejiang University Medical School, Hangzhou, China (F.S., J.Z.).
3 shared publications - Jianmin Zhang
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
3 shared publications Biao Jiang
Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
2 shared publicationsChenhan Ling
Department of Neurosurgery
2 shared publications
Latest Publications
- Open Access
Progress in artificial intelligence applications based on the combination of self-driven sensors and deep learning
In the era of Internet of Things, how to develop a smart sensor system with sustainable power supply, easy deployment and flexible use has become a difficult problem to be solved. The traditional power supply has problems such as frequent replacement or charging when in use, which limits the development of wearable devices. The contact-to-separate friction nanogenerator (TENG) was prepared by using polychotomy thy lene (PTFE) and aluminum (AI) foils. Human motion energy was collected by human body arrangement, and human motion posture was monitored according to the changes of output electrical signals. In 2012, Academician Wang Zhong lin and his team invented the triboelectric nanogenerator (TENG), which uses Maxwell displacement current as a driving force to directly convert mechanical stimuli into electrical signals, so it can be used as a self-driven sensor. Teng-based sensors have the advantages of simple structure and high instantaneous power density, which provides an important means for building intelligent sensor systems. At the same time, machine learning, as a technology with low cost, short development cycle, strong data processing ability and prediction ability, has a significant effect on the processing of a large number of electrical signals generated by TENG, and the combination with TENG sensors will promote the rapid development of intelligent sensor networks in the future. Therefore, this paper is based on the intelligent sound monitoring and recognition system of TENG, which has good sound recognition capability, and aims to evaluate the feasibility of the sound perception module architecture in ubiquitous sensor networks.
Open AccessProgress in artificial intelligence applications based on the combination of self-driven sensors and deep learning
In the era of Internet of Things, how to develop a smart sensor system with sustainable power supply, easy deployment and flexible use has become a difficult problem to be solved. The traditional power supply has problems such as frequent replacement or charging when in use, which limits the development of wearable devices. The contact-to-separate friction nanogenerator (TENG) was prepared by using polychotomy thy lene (PTFE) and aluminum (AI) foils. Human motion energy was collected by human body arrangement, and human motion posture was monitored according to the changes of output electrical signals. In 2012, Academician Wang Zhong lin and his team invented the triboelectric nanogenerator (TENG), which uses Maxwell displacement current as a driving force to directly convert mechanical stimuli into electrical signals, so it can be used as a self-driven sensor. Teng-based sensors have the advantages of simple structure and high instantaneous power density, which provides an important means for building intelligent sensor systems. At the same time, machine learning, as a technology with low cost, short development cycle, strong data processing ability and prediction ability, has a significant effect on the processing of a large number of electrical signals generated by TENG, and the combination with TENG sensors will promote the rapid development of intelligent sensor networks in the future. Therefore, this paper is based on the intelligent sound monitoring and recognition system of TENG, which has good sound recognition capability, and aims to evaluate the feasibility of the sound perception module architecture in ubiquitous sensor networks.
- Open Access
- 19 January 2024
- Published by Association for Computing Machinery (ACM)
- p. 516-519
Combine deep learning and artificial intelligence to optimize the application path of digital image processing technology
Artificial intelligence provides a new research concept for digital image processing. However, at present, artificial intelligence is rarely introduced into the teaching of digital image processing in colleges and universities, and there are problems such as obsolete teaching content, single teaching method and simple course experiment, which affect the teaching effect and are not conducive to the cultivation of comprehensive and innovative talents. Digital image processing technology brings more possibilities to communication engineering and makes people's communication more convenient. For example, video calls and photo transmission make people's communication methods in daily life more and more diversified. The limitation of time and space allows people to meet online, creating more communication possibilities. However, there are still many problems and methods worthy of in-depth exploration. Therefore, this paper has a comprehensive understanding and mastery of the traditional methods and deep learning methods of digital image processing, so as to improve the relevant project practice and scientific research exploration ability, and make reference for similar research conclusions.
- 19 January 2024
- Published by Association for Computing Machinery (ACM)
- p. 516-519
Open AccessCombine deep learning and artificial intelligence to optimize the application path of digital image processing technology
Artificial intelligence provides a new research concept for digital image processing. However, at present, artificial intelligence is rarely introduced into the teaching of digital image processing in colleges and universities, and there are problems such as obsolete teaching content, single teaching method and simple course experiment, which affect the teaching effect and are not conducive to the cultivation of comprehensive and innovative talents. Digital image processing technology brings more possibilities to communication engineering and makes people's communication more convenient. For example, video calls and photo transmission make people's communication methods in daily life more and more diversified. The limitation of time and space allows people to meet online, creating more communication possibilities. However, there are still many problems and methods worthy of in-depth exploration. Therefore, this paper has a comprehensive understanding and mastery of the traditional methods and deep learning methods of digital image processing, so as to improve the relevant project practice and scientific research exploration ability, and make reference for similar research conclusions.
- 23 June 2022
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 43 (7) , 966-971
Quantitative Collateral Assessment on CTP in the Prediction of Stroke Etiology
BACKGROUND AND PURPOSE: Patients with stroke etiology of large-artery atherosclerosis were thought to have better collateral circulation compared with patients with other stroke etiologies. We aimed to investigate the association between stroke etiology and collateral circulation with a new quantitative collateral assessment method. MATERIALS AND METHODS: This retrospective study reviewed data from consecutive patients with proximal anterior artery occlusion who underwent CTP before reperfusion therapy. CBF maps were derived from CTP. A new indicator, maximum CBF of collateral vessels within the Sylvian fissure (cCBFmax), was applied to quantitatively assess the collateral status. The relationship between collateral status and stroke etiology was investigated. RESULTS: A total of 296 patients were finally analyzed. The median cCBFmax was significantly higher in patients with large-artery atherosclerosis than in those without it (92 [interquartile range, 65–123] mL/100 g/min versus 62 [interquartile range, 46–82] mL/100 g/min; P < .001). Multivariable analysis revealed that a higher cCBFmax score was independently associated with large-artery atherosclerosis etiology (OR, 1.010; 95% CI, 1.002–1.018; P = .017) after adjustment. The area under the curve, sensitivity, and specificity of the final model in predicting the etiology of large-artery atherosclerosis were 0.870, 89.7%, and 75.2%, respectively. CONCLUSIONS: Patients with large-artery atherosclerosis had a more adequate collateral perfusion supply with the new quantitative collateral assessment. The new quantitative collateral measurement might contribute to the prediction of stroke etiology in the acute clinical scenario for patients with acute ischemic stroke.
- 23 June 2022
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 43 (7) , 966-971
Quantitative Collateral Assessment on CTP in the Prediction of Stroke Etiology
BACKGROUND AND PURPOSE: Patients with stroke etiology of large-artery atherosclerosis were thought to have better collateral circulation compared with patients with other stroke etiologies. We aimed to investigate the association between stroke etiology and collateral circulation with a new quantitative collateral assessment method. MATERIALS AND METHODS: This retrospective study reviewed data from consecutive patients with proximal anterior artery occlusion who underwent CTP before reperfusion therapy. CBF maps were derived from CTP. A new indicator, maximum CBF of collateral vessels within the Sylvian fissure (cCBFmax), was applied to quantitatively assess the collateral status. The relationship between collateral status and stroke etiology was investigated. RESULTS: A total of 296 patients were finally analyzed. The median cCBFmax was significantly higher in patients with large-artery atherosclerosis than in those without it (92 [interquartile range, 65–123] mL/100 g/min versus 62 [interquartile range, 46–82] mL/100 g/min; P < .001). Multivariable analysis revealed that a higher cCBFmax score was independently associated with large-artery atherosclerosis etiology (OR, 1.010; 95% CI, 1.002–1.018; P = .017) after adjustment. The area under the curve, sensitivity, and specificity of the final model in predicting the etiology of large-artery atherosclerosis were 0.870, 89.7%, and 75.2%, respectively. CONCLUSIONS: Patients with large-artery atherosclerosis had a more adequate collateral perfusion supply with the new quantitative collateral assessment. The new quantitative collateral measurement might contribute to the prediction of stroke etiology in the acute clinical scenario for patients with acute ischemic stroke.
- Open Access
- 15 January 2021
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 10
Effectiveness of Postoperative Adjuvant Radiotherapy in Atypical Meningioma Patients After Gross Total Resection: A Meta-Analysis Study
Background: It still remains unclear whether patients with atypical meningioma (AM) could benefit from postoperative adjuvant radiotherapy (PORT) after gross-total resection (GTR).Objective: Exploring the effectiveness of PORT on AM patients after GTR.Methods: Literatures on PubMed, Embase, Web of science, and Scopus databases published between January 2000 and January 2019 were searched. After the selection based on the certain exclusion criteria, the Newcastle-Ottawa evaluation scale was used to evaluate the quality of the included literatures. Finally, a meta-analysis was conducted to analyze the effectiveness of PORT on local control (LC), progression-free survival (PFS) and overall survival (OS) in atypical meningioma patients after GTR.Results: A total of 17 articles with 2,008 AM patients were included in the meta-analysis. The 5-year LC, 5-year PFS, and 5-year OS rates were 82.2, 84.1, and 79.0%, respectively, for AM patients receiving PORT after GTR, and they were 71.0, 71.9, and 81.5%, respectively, for those not receiving PORT after GTR. PORT could significantly improve 5-year LC rate (OR [95% Cl] = 2.59 [1.40–4.81], P = 0.002) and 5-year PFS rate (OR [95% Cl] = 1.99 [1.35–2.95], P = 0.001), but did not significantly improve 5-year OS rate (OR [95% Cl] = 1.07 [0.60–1.91], P = 0.828).Conclusion: PORT could improve the 5-year LC rate and 5-year PFS rate in AM patients after GTR. AM patients might benefit from PORT after GTR.
- 15 January 2021
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 10
Open AccessEffectiveness of Postoperative Adjuvant Radiotherapy in Atypical Meningioma Patients After Gross Total Resection: A Meta-Analysis Study
Background: It still remains unclear whether patients with atypical meningioma (AM) could benefit from postoperative adjuvant radiotherapy (PORT) after gross-total resection (GTR).Objective: Exploring the effectiveness of PORT on AM patients after GTR.Methods: Literatures on PubMed, Embase, Web of science, and Scopus databases published between January 2000 and January 2019 were searched. After the selection based on the certain exclusion criteria, the Newcastle-Ottawa evaluation scale was used to evaluate the quality of the included literatures. Finally, a meta-analysis was conducted to analyze the effectiveness of PORT on local control (LC), progression-free survival (PFS) and overall survival (OS) in atypical meningioma patients after GTR.Results: A total of 17 articles with 2,008 AM patients were included in the meta-analysis. The 5-year LC, 5-year PFS, and 5-year OS rates were 82.2, 84.1, and 79.0%, respectively, for AM patients receiving PORT after GTR, and they were 71.0, 71.9, and 81.5%, respectively, for those not receiving PORT after GTR. PORT could significantly improve 5-year LC rate (OR [95% Cl] = 2.59 [1.40–4.81], P = 0.002) and 5-year PFS rate (OR [95% Cl] = 1.99 [1.35–2.95], P = 0.001), but did not significantly improve 5-year OS rate (OR [95% Cl] = 1.07 [0.60–1.91], P = 0.828).Conclusion: PORT could improve the 5-year LC rate and 5-year PFS rate in AM patients after GTR. AM patients might benefit from PORT after GTR.
- Open Access
- 1 November 2019
- Published by Wolters Kluwer Health in Medicine
- Vol. 98 (46) , e17949
In vivo measurement of cytoplasmic organelle water fraction using diffusion-weighted imaging
Recently, we have proposed a theoretical modified tri-exponential model for multi-b-value diffusion-weighted imaging (DWI) to measure the cytoplasmic organelle water fraction (COWF). This study aims to investigate whether COWF maps are effective in evaluating the malignant degree of gliomas and distinguishing primary central nervous system lymphomas (PCNSL) from gliomas. We performed this retrospective study based on our prospectively collected data. All patients underwent preoperative multi-b-value DWI. Parametric maps were derived from multi-b-value DWI maps using the modified tri-exponential model. Receiver operating characteristic analyses were used to assess the diagnostic accuracy of the parameter maps. Pearson correlation coefficients were calculated to investigate the correlations between the parameters and the Ki-67 proliferation index. A total of 66 patients were enrolled, including 16 low-grade gliomas (LGG), 45 high-grade gliomas (HGG), and 5 PCNSL. The mean COWF values were significantly different among LGG (3.1 ± 1.4%), HGG (6.9 ± 2.8%), and PCNSL (14.0 ± 2.2%) (P < .001). The areas under the curves of the mean COWF value in distinguishing HGG from LGG and distinguishing PCNSL from gliomas were 0.899 and 0.980, respectively. The mean COWF value had a moderate correlation with the Ki-67 proliferation index (r = 0.647). The COWF map is useful in malignant grading of gliomas, and may be helpful in distinguishing PCNSL from gliomas.
- 1 November 2019
- Published by Wolters Kluwer Health in Medicine
- Vol. 98 (46) , e17949
Open AccessIn vivo measurement of cytoplasmic organelle water fraction using diffusion-weighted imaging
Recently, we have proposed a theoretical modified tri-exponential model for multi-b-value diffusion-weighted imaging (DWI) to measure the cytoplasmic organelle water fraction (COWF). This study aims to investigate whether COWF maps are effective in evaluating the malignant degree of gliomas and distinguishing primary central nervous system lymphomas (PCNSL) from gliomas. We performed this retrospective study based on our prospectively collected data. All patients underwent preoperative multi-b-value DWI. Parametric maps were derived from multi-b-value DWI maps using the modified tri-exponential model. Receiver operating characteristic analyses were used to assess the diagnostic accuracy of the parameter maps. Pearson correlation coefficients were calculated to investigate the correlations between the parameters and the Ki-67 proliferation index. A total of 66 patients were enrolled, including 16 low-grade gliomas (LGG), 45 high-grade gliomas (HGG), and 5 PCNSL. The mean COWF values were significantly different among LGG (3.1 ± 1.4%), HGG (6.9 ± 2.8%), and PCNSL (14.0 ± 2.2%) (P < .001). The areas under the curves of the mean COWF value in distinguishing HGG from LGG and distinguishing PCNSL from gliomas were 0.899 and 0.980, respectively. The mean COWF value had a moderate correlation with the Ki-67 proliferation index (r = 0.647). The COWF map is useful in malignant grading of gliomas, and may be helpful in distinguishing PCNSL from gliomas.
- Open Access
- 21 May 2019
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 9, 424
Bright Edge Sign on High b-Value Diffusion-Weighted Imaging as a New Imaging Biomarker to Predict Poor Prognosis in Glioma Patients: A Retrospective Pilot Study
Purpose: To investigate the prognostic value of bright edge sign observed on high b-value diffusion-weighted imaging (DWI) map in glioma patients. Methods: We retrospectively reviewed our prospectively collected database for gliomas. Bright edge sign was defined as the presence of extremely high signal in tumor margin on high b-value DWI map (b = 3,000 s/mm2) with the signal intensity higher than those in contralateral normal white matter and tumor central region. Extremely poor prognosis was defined as overall survival time < 9 months. Survival analyses were conducted by using the Cox regression for both the univariable and multivariable analyses. Results: A total of 52 patients were enrolled (WHO IV, 25; WHO III, 13; WHO II, 14). Bright edge sign presented in 10 (19.2%) patients (WHO IV, 5; WHO III, 3; WHO II, 2). Nine (90.0%) patients with bright edge sign had extremely poor prognosis, while only 1 (2.4 %) patient without bright edge sign had extremely poor prognosis. The sensitivity and specificity of bright edge sign in determining extremely poor prognosis were 90 and 97.7%, respectively. Bright edge sign (HR [95% CI] = 25.11 [7.26–86.81], p < 0.001) was an independent predictor of poor prognosis after adjustment. Conclusion: Bright edge sign on high b-value DWI may be an accurate predictor of extremely poor prognosis in glioma patients, regardless of pathologic grades.
- 21 May 2019
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 9, 424
Open AccessBright Edge Sign on High b-Value Diffusion-Weighted Imaging as a New Imaging Biomarker to Predict Poor Prognosis in Glioma Patients: A Retrospective Pilot Study
Purpose: To investigate the prognostic value of bright edge sign observed on high b-value diffusion-weighted imaging (DWI) map in glioma patients. Methods: We retrospectively reviewed our prospectively collected database for gliomas. Bright edge sign was defined as the presence of extremely high signal in tumor margin on high b-value DWI map (b = 3,000 s/mm2) with the signal intensity higher than those in contralateral normal white matter and tumor central region. Extremely poor prognosis was defined as overall survival time < 9 months. Survival analyses were conducted by using the Cox regression for both the univariable and multivariable analyses. Results: A total of 52 patients were enrolled (WHO IV, 25; WHO III, 13; WHO II, 14). Bright edge sign presented in 10 (19.2%) patients (WHO IV, 5; WHO III, 3; WHO II, 2). Nine (90.0%) patients with bright edge sign had extremely poor prognosis, while only 1 (2.4 %) patient without bright edge sign had extremely poor prognosis. The sensitivity and specificity of bright edge sign in determining extremely poor prognosis were 90 and 97.7%, respectively. Bright edge sign (HR [95% CI] = 25.11 [7.26–86.81], p < 0.001) was an independent predictor of poor prognosis after adjustment. Conclusion: Bright edge sign on high b-value DWI may be an accurate predictor of extremely poor prognosis in glioma patients, regardless of pathologic grades.
- 1 March 2019
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 290 (3) , 760-768
Acute Stroke: Prognostic Value of Quantitative Collateral Assessment at Perfusion CT
The measurement of maximum cerebral blood flow in collateral vessels within the Sylvian fissure is an independent predictor for both hemorrhagic transformation and good outcome. Purpose To develop a quantitative assessment of collateral perfusion at CT and to investigate its value in the prediction of outcome in patients with acute ischemic stroke (AIS). Materials and Methods This retrospective study reviewed data from consecutive patients with AIS and an occluded M1 segment of the middle cerebral artery who underwent pretreatment perfusion CT between May 2009 and August 2017. The maximum cerebral blood flow (CBF) of collateral vessels (cCBFmax) within the Sylvian fissure was calculated for each patient. Good outcome was defined as a 90-day modified Rankin scale score of 0–2. Multivariable logistic regression analysis was used to determine the relationship between cCBFmax and (a) hemorrhagic transformation and (b) clinical outcome. Results The final analysis included 204 patients (median age, 73 years; interquartile range, 62–80 years; 82 [40.2%] women). Multivariable logistic regression analysis showed that higher cCBFmax was an independent predictor for (a) a lower risk of hemo...
- 1 March 2019
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 290 (3) , 760-768
Acute Stroke: Prognostic Value of Quantitative Collateral Assessment at Perfusion CT
The measurement of maximum cerebral blood flow in collateral vessels within the Sylvian fissure is an independent predictor for both hemorrhagic transformation and good outcome. Purpose To develop a quantitative assessment of collateral perfusion at CT and to investigate its value in the prediction of outcome in patients with acute ischemic stroke (AIS). Materials and Methods This retrospective study reviewed data from consecutive patients with AIS and an occluded M1 segment of the middle cerebral artery who underwent pretreatment perfusion CT between May 2009 and August 2017. The maximum cerebral blood flow (CBF) of collateral vessels (cCBFmax) within the Sylvian fissure was calculated for each patient. Good outcome was defined as a 90-day modified Rankin scale score of 0–2. Multivariable logistic regression analysis was used to determine the relationship between cCBFmax and (a) hemorrhagic transformation and (b) clinical outcome. Results The final analysis included 204 patients (median age, 73 years; interquartile range, 62–80 years; 82 [40.2%] women). Multivariable logistic regression analysis showed that higher cCBFmax was an independent predictor for (a) a lower risk of hemo...
- Open Access
- 31 January 2019
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 9, 34
Effectiveness of Postoperative Radiotherapy on Atypical Meningioma Patients: A Population-Based Study
Purpose: It is controversial whether atypical meningioma patients undergoing gross-total resection (GTR) can benefit from postoperative radiotherapy (PORT). This study aimed to investigate the effectiveness of PORT on atypical meningioma patients. Methods: Patients diagnosed with atypical meningioma from 2008 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan–Meier survival curves were generated, and the log-rank test was used to compare the differences among groups. Univariable and multivariable COX regressions were conducted for survival analyses. Results: A total of 1014 patients were enrolled. The 5-year survival rate of the overall patients was 79.0%. PORT was performed in 315 (31.1%) patients. The utilization rates of PORT in patients undergoing GTR and undergoing subtotal resection (STR) were 26.7% and 42.2%, respectively. For patients undergoing STR, log-rank test showed that overall survival (OS) time was significantly longer in patients receiving PORT than those not (p = 0.026). For patients undergoing GTR, OS time did not show significant association with PORT (p = 0.339). In addition, patients undergoing STR with PORT had no significantly different OS time compared with those undergoing GTR with PORT (p = 0.398). Multivariable Cox regression analysis showed that receipt of PORT (p = 0.187) was not an independent predictor of OS after adjustment. Conclusion: PORT may not prolong the OS in atypical meningioma patients undergoing GTR. However, patients undergoing STR may benefit from PORT and achieve similar OS to those undergoing GTR.
- 31 January 2019
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 9, 34
Open AccessEffectiveness of Postoperative Radiotherapy on Atypical Meningioma Patients: A Population-Based Study
Purpose: It is controversial whether atypical meningioma patients undergoing gross-total resection (GTR) can benefit from postoperative radiotherapy (PORT). This study aimed to investigate the effectiveness of PORT on atypical meningioma patients. Methods: Patients diagnosed with atypical meningioma from 2008 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan–Meier survival curves were generated, and the log-rank test was used to compare the differences among groups. Univariable and multivariable COX regressions were conducted for survival analyses. Results: A total of 1014 patients were enrolled. The 5-year survival rate of the overall patients was 79.0%. PORT was performed in 315 (31.1%) patients. The utilization rates of PORT in patients undergoing GTR and undergoing subtotal resection (STR) were 26.7% and 42.2%, respectively. For patients undergoing STR, log-rank test showed that overall survival (OS) time was significantly longer in patients receiving PORT than those not (p = 0.026). For patients undergoing GTR, OS time did not show significant association with PORT (p = 0.339). In addition, patients undergoing STR with PORT had no significantly different OS time compared with those undergoing GTR with PORT (p = 0.398). Multivariable Cox regression analysis showed that receipt of PORT (p = 0.187) was not an independent predictor of OS after adjustment. Conclusion: PORT may not prolong the OS in atypical meningioma patients undergoing GTR. However, patients undergoing STR may benefit from PORT and achieve similar OS to those undergoing GTR.
- 1 July 2018
- Published by Elsevier in World Neurosurgery
- Vol. 115, E688-E694
Number of Fractured Calvarial Bones Predicts Outcome in Traumatic Brain Injury Patients After Early Craniotomy
- 1 July 2018
- Published by Elsevier in World Neurosurgery
- Vol. 115, E688-E694
Number of Fractured Calvarial Bones Predicts Outcome in Traumatic Brain Injury Patients After Early Craniotomy
- Open Access
- 20 July 2017
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 38 (10) , 1876-1883
3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas
BACKGROUND AND PURPOSE: Previous studies showed conflicting results concerning the value of CBF maps obtained from arterial spin-labeling MR imaging in grading gliomas. This study was performed to investigate the effectiveness of CBF maps derived from 3D pseudocontinuous arterial spin-labeling in preoperatively assessing the grade, cellular proliferation, and prognosis of gliomas. MATERIALS AND METHODS: Fifty-eight patients with pathologically confirmed gliomas underwent preoperative 3D pseudocontinuous arterial spin-labeling. The receiver operating characteristic curves for parameters to distinguish high-grade gliomas from low-grade gliomas were generated. Pearson correlation analysis was used to assess the correlation among parameters. Survival analysis was conducted with Cox regression. RESULTS: Both maximum CBF and maximum relative CBF were significantly higher in high-grade gliomas than in low-grade gliomas (P < .001). The areas under the curve for maximum CBF and maximum relative CBF in distinguishing high-grade gliomas from low-grade gliomas were 0.828 and 0.863, respectively. Both maximum CBF and maximum relative CBF had no correlation with the Ki-67 index in all subjects and had a moderate negative correlation with the Ki-67 index in glioblastomas (r = −0.475, −0.534, respectively). After adjustment for age, a higher maximum CBF (P = .008) and higher maximum relative CBF (P = .005) were associated with worse progression-free survival in gliomas, while a higher maximum relative CBF (P = .033) was associated with better overall survival in glioblastomas. CONCLUSIONS: 3D pseudocontinuous arterial spin-labeling–derived CBF maps are effective in preoperative evaluation of gliomas. Although gliomas with a higher blood flow are more malignant, glioblastomas with a lower blood flow are likely to be more aggressive.
- 20 July 2017
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 38 (10) , 1876-1883
Open Access3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas
BACKGROUND AND PURPOSE: Previous studies showed conflicting results concerning the value of CBF maps obtained from arterial spin-labeling MR imaging in grading gliomas. This study was performed to investigate the effectiveness of CBF maps derived from 3D pseudocontinuous arterial spin-labeling in preoperatively assessing the grade, cellular proliferation, and prognosis of gliomas. MATERIALS AND METHODS: Fifty-eight patients with pathologically confirmed gliomas underwent preoperative 3D pseudocontinuous arterial spin-labeling. The receiver operating characteristic curves for parameters to distinguish high-grade gliomas from low-grade gliomas were generated. Pearson correlation analysis was used to assess the correlation among parameters. Survival analysis was conducted with Cox regression. RESULTS: Both maximum CBF and maximum relative CBF were significantly higher in high-grade gliomas than in low-grade gliomas (P < .001). The areas under the curve for maximum CBF and maximum relative CBF in distinguishing high-grade gliomas from low-grade gliomas were 0.828 and 0.863, respectively. Both maximum CBF and maximum relative CBF had no correlation with the Ki-67 index in all subjects and had a moderate negative correlation with the Ki-67 index in glioblastomas (r = −0.475, −0.534, respectively). After adjustment for age, a higher maximum CBF (P = .008) and higher maximum relative CBF (P = .005) were associated with worse progression-free survival in gliomas, while a higher maximum relative CBF (P = .033) was associated with better overall survival in glioblastomas. CONCLUSIONS: 3D pseudocontinuous arterial spin-labeling–derived CBF maps are effective in preoperative evaluation of gliomas. Although gliomas with a higher blood flow are more malignant, glioblastomas with a lower blood flow are likely to be more aggressive.