Paul C. Lott

Supplemental Table S4 shows a list of polymorphisms in the PRS panels with association analyses summary statistics from 7 pooled Hispanic/Latino datasets.

Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.

Supplemental Table S6 shows two-sided Hosmer-Lemeshow P values for calibration of the PRS panels tested in our datasets.

Supplemental Figure S4 shows effect of adding only one H/L SNP to European PRS panels on performance in H/L samples.

Supplemental Table S8 shows comparisons of performance of the PRS panel for different pair of ranges of Indigenous American (IA) ancestry.

Supplemental Table S2 shows performance of PRS panels constructed from PRS3820 European panel plus 2 H/L SNPs using different imputation r2 cutoffs.

Supplemental Table S7 shows comparisons of performance for the PRS panel pairs in different ranges of Indigenous American (IA) ancestry.

Supplemental Table S3 shows sample sizes in the Indigenous American ancestry ranges selected for our analysis.

Supplemental Figure S2 shows performance of PRS panels with addition of 2 or 3 H/L SNPs

Supplemental Table S5 shows Comparisons of Areas under the receiver operating characteristics curve (AUC) and odd ratios (OR) per standard deviation of the PRS panels.