William Nascimento Litaiff Nogueira
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
William Nascimento Litaiff Nogueira has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
- Cláudia Cândida Silva
Grupo Crowfoot de Métodos de Raios-X, School of Technology, Amazonas State University, Manaus 69050-020, Brazil
1 shared publication - Cícero Flávio Soares Aragão
Federal University of Rio Grande do Norte, Brazil
1 shared publication - Eduardo Pereira de Azevedo
Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, Brazil
1 shared publication - Elen Diana Dantas
Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil
1 shared publication - Emerson Silva Lima
Universidade Federal do Amazonas
1 shared publication - Euzébio Guimarães Barbosa
Universidade Federal do Rio Grande do Norte
1 shared publication
Latest Publications
- Open Access
Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone
Chagas disease is an endemic parasitic infection that occurs in 21 Latin American countries. New therapies for this disease are urgently needed, as the only two drugs available (nifurtimox and benznidazol) have high toxicity and variable efficacy in the disease’s chronic phase. Recently, a new chemical entity (NCE) named Pyranaphthoquinone (IVS320) was synthesized from lawsone. We report herein, a detailed study of the physicochemical properties and in vitro trypanocidal activity of IVS320. A series of assays were performed for characterization, where thermal, diffractometric, and morphological analysis were performed. In addition, the solubility, permeability, and hygroscopicity of IVS320 were determined. The results show that its poor solubility and low permeability may be due to its high degree of crystallinity (99.19%), which might require the use of proper techniques to increase the IVS320’s aqueous solubility and permeability. The trypanocidal activity study demonstrated that IVS320 is more potent than the reference drug benznidazole, with IC50/24 h of 1.49 ± 0.1 μM, which indicates that IVS320 has potential as a new drug candidate for the treatment of Chagas disease.
Open AccessCharacterization and Trypanocidal Activity of a Novel Pyranaphthoquinone
Chagas disease is an endemic parasitic infection that occurs in 21 Latin American countries. New therapies for this disease are urgently needed, as the only two drugs available (nifurtimox and benznidazol) have high toxicity and variable efficacy in the disease’s chronic phase. Recently, a new chemical entity (NCE) named Pyranaphthoquinone (IVS320) was synthesized from lawsone. We report herein, a detailed study of the physicochemical properties and in vitro trypanocidal activity of IVS320. A series of assays were performed for characterization, where thermal, diffractometric, and morphological analysis were performed. In addition, the solubility, permeability, and hygroscopicity of IVS320 were determined. The results show that its poor solubility and low permeability may be due to its high degree of crystallinity (99.19%), which might require the use of proper techniques to increase the IVS320’s aqueous solubility and permeability. The trypanocidal activity study demonstrated that IVS320 is more potent than the reference drug benznidazole, with IC50/24 h of 1.49 ± 0.1 μM, which indicates that IVS320 has potential as a new drug candidate for the treatment of Chagas disease.