Gladys León
Gladys León has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
Xavier Clotet
2 shared publications- Alejandro Zentella-Dehesa
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México 04510, Mexico
1 shared publication Dario Di Noto
1 shared publicationDavid Lund
1 shared publicationElisa Costante
1 shared publicationEstefanía Etchevés Miciolino
1 shared publication
Latest Publications
- 1 December 2018
- Published by Elsevier in International Journal of Critical Infrastructure Protection
- Vol. 23, 11-20
A real-time anomaly-based IDS for cyber-attack detection at the industrial process level of Critical Infrastructures
- 1 December 2018
- Published by Elsevier in International Journal of Critical Infrastructure Protection
- Vol. 23, 11-20
A real-time anomaly-based IDS for cyber-attack detection at the industrial process level of Critical Infrastructures
- 1 January 2017
- Published by Inderscience Publishers in International Journal of Critical Infrastructures
- Vol. 13 (2/3) , 206
Preemptive: an integrated approach to intrusion detection and prevention in industrial control systems
International publishers of academic, scientific and professional journals since 1979.
- 1 January 2017
- Published by Inderscience Publishers in International Journal of Critical Infrastructures
- Vol. 13 (2/3) , 206
Preemptive: an integrated approach to intrusion detection and prevention in industrial control systems
International publishers of academic, scientific and professional journals since 1979.
- 1 November 2011
- Published by JLE in European Journal Of Dermatology
- Vol. 21 (6) , 874-888
Pemphigus vulgaris: accumulation of apoptotic cells in dermis and epidermis possibly relates to pathophysiology through TNF-alpha production by phagocytes
Apoptotic cells are present in the epidermis of pemphigus vulgaris (PV) patients and their accumulation has been linked to chronic inflammatory disorders. TNF-α is elevated in sera of PV patients and has only been detected in acantholytic and periacantholytic keratinocytes (KC), therefore another TNF-α source might exist. We analyzed, in lesional and perilesional skin of 5 active untreated PV patients, the presence of apoptotic cells, TNF-α and phagocytic infiltrate. In vitro, we analyzed whether phagocytosis of apoptotic KCs by monocytes causes TNF-α release. We found a significant increase of apoptotic cells in the epidermis and dermis of PV patients, by TUNEL, and activated caspase-3. TNF-α was present in the skin of PV patients, especially in the dermis. Phagocytic CD14+ cells were increased, mostly in the dermis of PV patients. In vitro phagocytosis of apoptotic KCs by monocytes caused enhanced TNF-α production, which correlated with the number of apoptotic KCs in the co-culture. Thus, accumulation of apoptotic cells in PV could promote TNF-α production by monocytes, which could, in turn, cause further apoptosis, closing a vicious circle.
- 1 November 2011
- Published by JLE in European Journal Of Dermatology
- Vol. 21 (6) , 874-888
Pemphigus vulgaris: accumulation of apoptotic cells in dermis and epidermis possibly relates to pathophysiology through TNF-alpha production by phagocytes
Apoptotic cells are present in the epidermis of pemphigus vulgaris (PV) patients and their accumulation has been linked to chronic inflammatory disorders. TNF-α is elevated in sera of PV patients and has only been detected in acantholytic and periacantholytic keratinocytes (KC), therefore another TNF-α source might exist. We analyzed, in lesional and perilesional skin of 5 active untreated PV patients, the presence of apoptotic cells, TNF-α and phagocytic infiltrate. In vitro, we analyzed whether phagocytosis of apoptotic KCs by monocytes causes TNF-α release. We found a significant increase of apoptotic cells in the epidermis and dermis of PV patients, by TUNEL, and activated caspase-3. TNF-α was present in the skin of PV patients, especially in the dermis. Phagocytic CD14+ cells were increased, mostly in the dermis of PV patients. In vitro phagocytosis of apoptotic KCs by monocytes caused enhanced TNF-α production, which correlated with the number of apoptotic KCs in the co-culture. Thus, accumulation of apoptotic cells in PV could promote TNF-α production by monocytes, which could, in turn, cause further apoptosis, closing a vicious circle.