Erin Calaine Inglis
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Erin Calaine Inglis has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Juan Manuel Murias
College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar
4 shared publications Danilo Iannetta
Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
2 shared publications- Silvia Pogliaghi
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
2 shared publications - Daniel A. Keir
School of Kinesiology, The University of Western Ontario, London, Ontario, Canada
1 shared publication - Danilo Iannetta
Department of Anesthesiology University of Utah Salt Lake City Utah USA
1 shared publication Kaitlin M. McLay
Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
1 shared publication
Latest Publications
- 7 July 2025
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
Sex-differences in vascular adaptations to exercise training within different intensity domains
Cardiorespiratory fitness (commonly assessed as maximal oxygen consumption, V̇O2max) is an independent predictor of risk for cardiovascular disease-related mortality. Endurance exercise training is recognized as a clinically validated intervention to significantly increase V̇O2max, and growing evidence exists demonstrating a tight connection between endurance training intensity domain and changes in V̇O2max. However, whether the vascular adaptations to exercise training are also influenced by intensity domains is unknown. Also unknown is the potential influence of sex on these responses. Thus, we assessed domain-specific hemodynamic and lower limb vascular adaptations in seventy healthy sedentary adults (35 females and 35 males) that underwent 6 weeks of endurance exercise training within five (n=14 per group; 7 females and 7 males) intensity domains: moderate, MOD; lower heavy intensity, HVY1; upper heavy-intensity, HVY2; high-intensity interval training in the severe domain, HIIT; sprint-interval training in the extreme domain (SIT). We found that: i) HIIT was associated with greater changes in resting hemodynamics (i.e., increased in resting mean arterial pressure and femoral artery vascular conductance) compared to MOD; ii) changes in V̇O2max were positively associated with changes in resting vascular conductance, femoral artery diameter, and indexes of reactive hyperemia while negatively associated with femoral artery flow-mediated dilation in females; iii) sex-related associations between changes in V̇O2max and peripheral vascular adaptations were more evident in response to HIIT. Taken together, our findings indicate that peripheral vascular adaptations associated with changes in cardiorespiratory fitness are impacted by sex and the exercise intensity domain within which training is performed.
- 7 July 2025
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
Sex-differences in vascular adaptations to exercise training within different intensity domains
Cardiorespiratory fitness (commonly assessed as maximal oxygen consumption, V̇O2max) is an independent predictor of risk for cardiovascular disease-related mortality. Endurance exercise training is recognized as a clinically validated intervention to significantly increase V̇O2max, and growing evidence exists demonstrating a tight connection between endurance training intensity domain and changes in V̇O2max. However, whether the vascular adaptations to exercise training are also influenced by intensity domains is unknown. Also unknown is the potential influence of sex on these responses. Thus, we assessed domain-specific hemodynamic and lower limb vascular adaptations in seventy healthy sedentary adults (35 females and 35 males) that underwent 6 weeks of endurance exercise training within five (n=14 per group; 7 females and 7 males) intensity domains: moderate, MOD; lower heavy intensity, HVY1; upper heavy-intensity, HVY2; high-intensity interval training in the severe domain, HIIT; sprint-interval training in the extreme domain (SIT). We found that: i) HIIT was associated with greater changes in resting hemodynamics (i.e., increased in resting mean arterial pressure and femoral artery vascular conductance) compared to MOD; ii) changes in V̇O2max were positively associated with changes in resting vascular conductance, femoral artery diameter, and indexes of reactive hyperemia while negatively associated with femoral artery flow-mediated dilation in females; iii) sex-related associations between changes in V̇O2max and peripheral vascular adaptations were more evident in response to HIIT. Taken together, our findings indicate that peripheral vascular adaptations associated with changes in cardiorespiratory fitness are impacted by sex and the exercise intensity domain within which training is performed.
- 7 August 2024
- Published by Springer Nature in Sports Medicine
- Vol. 54 (12) , 2993-3003
The Respiratory Compensation Point: Mechanisms and Relation to the Maximal Metabolic Steady State
At a point during the latter third of an incremental exercise protocol, ventilation begins to exceed the rate of clearance of carbon dioxide (CO2) at the lungs (\({\dot{V}}\)CO2). The onset of this hyperventilation, which is confirmed by a fall from a period of stability in end-tidal and arterial CO2 tensions (PCO2), is referred to as the respiratory compensation point (RCP). The mechanisms that contribute to the RCP remain debated as does its surrogacy for the maximal metabolic steady state of constant-power exercise (i.e., the highest work rate associated with maintenance of physiological steady state). The objective of this current opinion is to summarize the original research contributions that support and refute the hypotheses that: (i) the RCP represents a rapid, peripheral chemoreceptor-mediated reflex response engaged when the metabolic rate at which the buffering systems can no longer constrain the rise in hydrogen ions ([H+]) associated with rising lactate concentration and metabolic CO2 production is surpassed; and (ii) the metabolic rate at which this occurs is equivalent to the maximal metabolic steady state of constant power exercise. In doing so, we will shed light on potential mechanisms contributing to the RCP, attempt to reconcile disparate findings, make a case for its adoption for exercise intensity stratification and propose strategies for the use of RCP in aerobic exercise prescription.- 7 August 2024
- Published by Springer Nature in Sports Medicine
- Vol. 54 (12) , 2993-3003
The Respiratory Compensation Point: Mechanisms and Relation to the Maximal Metabolic Steady State
At a point during the latter third of an incremental exercise protocol, ventilation begins to exceed the rate of clearance of carbon dioxide (CO2) at the lungs (\({\dot{V}}\)CO2). The onset of this hyperventilation, which is confirmed by a fall from a period of stability in end-tidal and arterial CO2 tensions (PCO2), is referred to as the respiratory compensation point (RCP). The mechanisms that contribute to the RCP remain debated as does its surrogacy for the maximal metabolic steady state of constant-power exercise (i.e., the highest work rate associated with maintenance of physiological steady state). The objective of this current opinion is to summarize the original research contributions that support and refute the hypotheses that: (i) the RCP represents a rapid, peripheral chemoreceptor-mediated reflex response engaged when the metabolic rate at which the buffering systems can no longer constrain the rise in hydrogen ions ([H+]) associated with rising lactate concentration and metabolic CO2 production is surpassed; and (ii) the metabolic rate at which this occurs is equivalent to the maximal metabolic steady state of constant power exercise. In doing so, we will shed light on potential mechanisms contributing to the RCP, attempt to reconcile disparate findings, make a case for its adoption for exercise intensity stratification and propose strategies for the use of RCP in aerobic exercise prescription.- Open Access
- 25 July 2019
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 14 (7) , e0220192
Evaluating the NIRS-derived microvascular O2 extraction “reserve” in groups varying in sex and training status using leg blood flow occlusions
It has been demonstrated that the plateau in the near-infrared spectroscopy (NIRS) derived deoxygenated hemoglobin and myoglobin (deoxy[Hb+Mb]) signal (i.e., deoxy[Hb+Mb]PLATEAU) towards the end of a ramp-incremental (RI) test does not represent the upper-limit in O2 extraction of the vastus lateralis (VL) muscle, given that an O2 extraction reserve has been recently observed. This study aimed to investigate whether this O2 extraction reserve was present in various populations and whether it exhibited sex- and/or training- related differences.Sixteen men- 8 untrained (27±5 years; 83±11 kg; 179±9 cm), 8 trained (27±4 years; 82±10 kg; 182±8 cm) and 9 trained women (27±2 years; 66±10 kg; 172±6 cm) performed a RI cycling test to exhaustion. The NIRS-derived deoxy[Hb+Mb] signal was measured continuously on the VL as a proxy for O2 extraction. A leg blood flow occlusion (i.e., ischemia) was performed at rest (LBFOCC 1) and immediately post the RI test (LBFOCC 2).No significant difference was found between the deoxy[Hb+Mb] amplitude during LBFOCC 1 and the deoxy[Hb+Mb]PLATEAU (p>0.05) nor between baseline (bsln) deoxy[Hb+Mb] values. deoxy[Hb+Mb] amplitude during LBFOCC 2 was significantly greater than LBFOCC 1 and at deoxy[Hb+Mb]PLATEAU (pPLATEAU and LBFOCC 1 (p2 extraction reserve, regardless of sex- or training-statusThe results of this study demonstrated the existence of an O2 extraction reserve in different populations, and that neither sex- nor training-related differences affect the amplitude of the reserve.
- 25 July 2019
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 14 (7) , e0220192
Open AccessEvaluating the NIRS-derived microvascular O2 extraction “reserve” in groups varying in sex and training status using leg blood flow occlusions
It has been demonstrated that the plateau in the near-infrared spectroscopy (NIRS) derived deoxygenated hemoglobin and myoglobin (deoxy[Hb+Mb]) signal (i.e., deoxy[Hb+Mb]PLATEAU) towards the end of a ramp-incremental (RI) test does not represent the upper-limit in O2 extraction of the vastus lateralis (VL) muscle, given that an O2 extraction reserve has been recently observed. This study aimed to investigate whether this O2 extraction reserve was present in various populations and whether it exhibited sex- and/or training- related differences.Sixteen men- 8 untrained (27±5 years; 83±11 kg; 179±9 cm), 8 trained (27±4 years; 82±10 kg; 182±8 cm) and 9 trained women (27±2 years; 66±10 kg; 172±6 cm) performed a RI cycling test to exhaustion. The NIRS-derived deoxy[Hb+Mb] signal was measured continuously on the VL as a proxy for O2 extraction. A leg blood flow occlusion (i.e., ischemia) was performed at rest (LBFOCC 1) and immediately post the RI test (LBFOCC 2).No significant difference was found between the deoxy[Hb+Mb] amplitude during LBFOCC 1 and the deoxy[Hb+Mb]PLATEAU (p>0.05) nor between baseline (bsln) deoxy[Hb+Mb] values. deoxy[Hb+Mb] amplitude during LBFOCC 2 was significantly greater than LBFOCC 1 and at deoxy[Hb+Mb]PLATEAU (pPLATEAU and LBFOCC 1 (p2 extraction reserve, regardless of sex- or training-statusThe results of this study demonstrated the existence of an O2 extraction reserve in different populations, and that neither sex- nor training-related differences affect the amplitude of the reserve.