Chen Cao
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Chen Cao has a total of 29 co-authors. Here are the top co-authors by number of shared publications:
Bing Zhang
5 shared publications- Keiichiro Kagawa
Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan
5 shared publications Junfeng Wang
4 shared publications- Keita Yasutomi
Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan
4 shared publications Longsheng Wu
4 shared publicationsNorimichi Tsumura
Department of Information and Image Sciences, Chiba University, Chiba, Japan
4 shared publications
Latest Publications
- Open Access
- 1 January 2024
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 29 (01) , 016006-14
Motion-resistant three-wavelength spatial frequency domain imaging system with ambient light suppression using an 8-tap CMOS image sensor
Monitoring tissue metabolic and perfusion information such as oxygenation and hemoglobin concentration plays a crucial role in healthcare and therapy. Traditional methods commonly used to obtain such information include using a pulse oximeter1 attached to the patient’s finger or employing near-infrared spectroscopy (NIRS)2 using probes. However, neither of them can provide noncontact measurements nor cover a wide field of view. Spatial frequency domain imaging (SFDI) is an imaging technique that projects structured light with different spatial frequencies and phases onto diffusely reflecting objects to quantify absorption and reduced scattering coefficients.3,4 SFDI is a noninvasive, noncontact, real-time, wide-field, quantitative imaging technique. Compact SFDI systems designed for bedside use have been employed in various experiments, including predicting diabetic foot ulcer,5 – 7 oxygenation measurement during reconstructive breast surgery,8 monitoring skin cancer,9 imaging and staging pressure ulcers,10 among others. SFDI is a particularly promising method for diagnosing burn severity since changes in reduced scattering measured using SFDI have been shown to correlate with histologically verified changes in collagen as a function of burn severity. These changes can be detected as early as 24 h after the burn.11,12 This change in scattering, along with tissue oxygen saturation () and total hemoglobin concentration () derived from absorption coefficients, enable clinicians to make improved treatment decisions and can sometimes lead to early recovery for the patient.13 To accurately quantify tissue metabolic information, particularly the concentrations of oxy/deoxy hemoglobin, we require SFDI measurements at two or more wavelengths. However, since the presence of melanin in the epidermis can complicate the measurement results of other tissue chromophores, at least three wavelengths (as many as the number of chromophores) are generally required to achieve accurate determination of oxy and deoxyhemoglobin concentrations.- 1 January 2024
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 29 (01) , 016006-14
Open AccessMotion-resistant three-wavelength spatial frequency domain imaging system with ambient light suppression using an 8-tap CMOS image sensor
Monitoring tissue metabolic and perfusion information such as oxygenation and hemoglobin concentration plays a crucial role in healthcare and therapy. Traditional methods commonly used to obtain such information include using a pulse oximeter1 attached to the patient’s finger or employing near-infrared spectroscopy (NIRS)2 using probes. However, neither of them can provide noncontact measurements nor cover a wide field of view. Spatial frequency domain imaging (SFDI) is an imaging technique that projects structured light with different spatial frequencies and phases onto diffusely reflecting objects to quantify absorption and reduced scattering coefficients.3,4 SFDI is a noninvasive, noncontact, real-time, wide-field, quantitative imaging technique. Compact SFDI systems designed for bedside use have been employed in various experiments, including predicting diabetic foot ulcer,5 – 7 oxygenation measurement during reconstructive breast surgery,8 monitoring skin cancer,9 imaging and staging pressure ulcers,10 among others. SFDI is a particularly promising method for diagnosing burn severity since changes in reduced scattering measured using SFDI have been shown to correlate with histologically verified changes in collagen as a function of burn severity. These changes can be detected as early as 24 h after the burn.11,12 This change in scattering, along with tissue oxygen saturation () and total hemoglobin concentration () derived from absorption coefficients, enable clinicians to make improved treatment decisions and can sometimes lead to early recovery for the patient.13 To accurately quantify tissue metabolic information, particularly the concentrations of oxy/deoxy hemoglobin, we require SFDI measurements at two or more wavelengths. However, since the presence of melanin in the epidermis can complicate the measurement results of other tissue chromophores, at least three wavelengths (as many as the number of chromophores) are generally required to achieve accurate determination of oxy and deoxyhemoglobin concentrations. - 5 November 2021
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Electron Devices
- Vol. 69 (6) , 2851-2857
Signal-to-Noise Ratio Enhancement in Cardiac Pulse Measurements Using Multitap CMOS Image Sensors With In-Pixel Temporal Redundant Samplings
Insufficient signal-to-noise ratio (SNR) limits the quality of cardiac pulses measured by multitap CMOS image sensors (CISs). We present an in-pixel temporal redundant samplings (TRS) method for enhancing the SNR through sampling the charges originated by one individual optical scene into the multiple storage taps in turn with the identical time window, enabling magnification of the image signal in shot noise domain. Modeling indicates that the linear SNR increases with a factor square root of TRS sampling number, which is also verified by characterization results utilizing a four-tap CIS. Application results show that the high-frequency (HF) noise components observed in the measured cardiac pulses can be attenuated by 67.9%, 48%, and 53.6% with heart rate detection accuracies up to 99.7%, 99.3%, and 98.7% by applying TRS modes under given conditions of stable ambient, background light (BGL) variation, and motion disturbance, respectively. Moreover, the proposed method is as well foreseeable to be extended to other multitap-involved imaging applications.
- 5 November 2021
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Electron Devices
- Vol. 69 (6) , 2851-2857
Signal-to-Noise Ratio Enhancement in Cardiac Pulse Measurements Using Multitap CMOS Image Sensors With In-Pixel Temporal Redundant Samplings
Insufficient signal-to-noise ratio (SNR) limits the quality of cardiac pulses measured by multitap CMOS image sensors (CISs). We present an in-pixel temporal redundant samplings (TRS) method for enhancing the SNR through sampling the charges originated by one individual optical scene into the multiple storage taps in turn with the identical time window, enabling magnification of the image signal in shot noise domain. Modeling indicates that the linear SNR increases with a factor square root of TRS sampling number, which is also verified by characterization results utilizing a four-tap CIS. Application results show that the high-frequency (HF) noise components observed in the measured cardiac pulses can be attenuated by 67.9%, 48%, and 53.6% with heart rate detection accuracies up to 99.7%, 99.3%, and 98.7% by applying TRS modes under given conditions of stable ambient, background light (BGL) variation, and motion disturbance, respectively. Moreover, the proposed method is as well foreseeable to be extended to other multitap-involved imaging applications.
- 12 February 2021
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Electron Devices
- Vol. 68 (4) , 1688-1693
A Dual NIR-Band Lock-In Pixel CMOS Image Sensor With Device Optimizations for Remote Physiological Monitoring
A 7.1- μm-pitch lock-in pixel (LIP) CMOS image sensor (CIS) that is capable of simultaneously phasing with two different near-infrared-band (NIR-band) light pulses is developed for remote physiological measurement, particularly a heart rate variability (HRV) signal monitor. The proposed dual NIR-band lock-in operation is realized by a four-tap-wise charge modulation with adjacent two-tap LIPs by means of a column-interdigital pixel driving scheme combining with in-LIP lateral electric field modulators (LEFMs). For attaining the weak HRV signal, the implemented CIS achieves a subelectron temporal noise of 0.67 e - rms at 64 times correlated multiple sampling (CMS) and a high charge modulation contrast (MC) up to 96% at maximum. These remarkable properties primarily result from the in-LIP dark current and LEFM controlling optimizations proposed in device domain. The experimental results show that the developed CIS exhibits not only a 98.5% accuracy in HRV signal capture with -39.1-dB signal-to-background ratio (SBR) against a fluctuant brightness ambient light but also a moderate artificial motion robustness benefited from the proposed dual NIR-band lock-in technique.
- 12 February 2021
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Electron Devices
- Vol. 68 (4) , 1688-1693
A Dual NIR-Band Lock-In Pixel CMOS Image Sensor With Device Optimizations for Remote Physiological Monitoring
A 7.1- μm-pitch lock-in pixel (LIP) CMOS image sensor (CIS) that is capable of simultaneously phasing with two different near-infrared-band (NIR-band) light pulses is developed for remote physiological measurement, particularly a heart rate variability (HRV) signal monitor. The proposed dual NIR-band lock-in operation is realized by a four-tap-wise charge modulation with adjacent two-tap LIPs by means of a column-interdigital pixel driving scheme combining with in-LIP lateral electric field modulators (LEFMs). For attaining the weak HRV signal, the implemented CIS achieves a subelectron temporal noise of 0.67 e - rms at 64 times correlated multiple sampling (CMS) and a high charge modulation contrast (MC) up to 96% at maximum. These remarkable properties primarily result from the in-LIP dark current and LEFM controlling optimizations proposed in device domain. The experimental results show that the developed CIS exhibits not only a 98.5% accuracy in HRV signal capture with -39.1-dB signal-to-background ratio (SBR) against a fluctuant brightness ambient light but also a moderate artificial motion robustness benefited from the proposed dual NIR-band lock-in technique.
- 21 December 2018
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Journal of Solid-State Circuits
- Vol. 54 (4) , 978-991
A Time-Resolved NIR Lock-In Pixel CMOS Image Sensor With Background Cancelling Capability for Remote Heart Rate Detection
This paper presents a time-resolved (TR) CMOS image sensor (CIS) using two-tap near-infrared (NIR) lock-in pixels with background light (BGL) cancelling capability for remote heart rate (HR) detection. Aimed to the application, the sensor features a 1024 (V) x 1280 (H) spatial resolution with 412 (V)x 1280 (H) region-of-interest-readout (ROI-readout) at 30 fps, a high sensitivity of 134.8 ke⁻/lux · s, and an ultra-low temporal random noise of 1.13 erms⁻ at analog gain of 64. A maximum charge modulation ratio of 90.1% is obtained for realizing lock-in operation by means of in-pixel lateral electric field charge modulator (LEFM). The remote HR detection is achieved by capturing the heart-beat-induced temporal variation of the oxy-hemoglobin (HbO₂) concentration by the developed TR CIS with NIR lock-in technique, and larger than 98% detection accuracies are attained under both non-visible-light condition and fluctuant brightness ambient-light environments. This remarkable feature demonstrates the superiority of the proposed method for driver monitoring applications in particular.
- 21 December 2018
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Journal of Solid-State Circuits
- Vol. 54 (4) , 978-991
A Time-Resolved NIR Lock-In Pixel CMOS Image Sensor With Background Cancelling Capability for Remote Heart Rate Detection
This paper presents a time-resolved (TR) CMOS image sensor (CIS) using two-tap near-infrared (NIR) lock-in pixels with background light (BGL) cancelling capability for remote heart rate (HR) detection. Aimed to the application, the sensor features a 1024 (V) x 1280 (H) spatial resolution with 412 (V)x 1280 (H) region-of-interest-readout (ROI-readout) at 30 fps, a high sensitivity of 134.8 ke⁻/lux · s, and an ultra-low temporal random noise of 1.13 erms⁻ at analog gain of 64. A maximum charge modulation ratio of 90.1% is obtained for realizing lock-in operation by means of in-pixel lateral electric field charge modulator (LEFM). The remote HR detection is achieved by capturing the heart-beat-induced temporal variation of the oxy-hemoglobin (HbO₂) concentration by the developed TR CIS with NIR lock-in technique, and larger than 98% detection accuracies are attained under both non-visible-light condition and fluctuant brightness ambient-light environments. This remarkable feature demonstrates the superiority of the proposed method for driver monitoring applications in particular.
- 1 June 2018
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 75-76
A Two-Tap NIR Lock-in Pixel CMOS Image Sensor with Background Light Cancelling Capability for Non-Contact Heart Rate Detection
A time-resolved CMOS image sensor (CIS) using two-tap near infrared (NIR) lock-in pixels with background light (BGL) cancelling capability for non-contact heart rate (HR) detection is presented. Aimed to the application, the sensor performances of 1.1e - rms temporal random noise and 90.1% maximum charge modulation ratio are achieved by using low noise readout circuit and in-pixel lateral electric field charge modulator (LEFM) techniques. The non-contact HR detection with accuracies of more than 98% is implemented by the developed sensor under both non-visible-light and fluctuant ambient-light brightness conditions. This remarkable performance indicates the superiority of the proposed technique for automotive security applications in particular.
- 1 June 2018
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 75-76
A Two-Tap NIR Lock-in Pixel CMOS Image Sensor with Background Light Cancelling Capability for Non-Contact Heart Rate Detection
A time-resolved CMOS image sensor (CIS) using two-tap near infrared (NIR) lock-in pixels with background light (BGL) cancelling capability for non-contact heart rate (HR) detection is presented. Aimed to the application, the sensor performances of 1.1e - rms temporal random noise and 90.1% maximum charge modulation ratio are achieved by using low noise readout circuit and in-pixel lateral electric field charge modulator (LEFM) techniques. The non-contact HR detection with accuracies of more than 98% is implemented by the developed sensor under both non-visible-light and fluctuant ambient-light brightness conditions. This remarkable performance indicates the superiority of the proposed technique for automotive security applications in particular.
- 1 May 2016
- Published by IOP Publishing in Journal of Semiconductors
- Vol. 37 (5) , 054007
Measurement of charge transfer potential barrier in pinned photodiode CMOS image sensors
The charge transfer potential barrier (CTPB) formed beneath the transfer gate causes a noticeable image lag issue in pinned photodiode (PPD) CMOS image sensors (CIS), and is difficult to measure straightforwardly since it is embedded inside the device. From an understanding of the CTPB formation mechanism, we report on an alternative method to feasibly measure the CTPB height by performing a linear extrapolation coupled with a horizontal left-shift on the sensor photoresponse curve under the steady-state illumination. The theoretical study was performed in detail on the principle of the proposed method. Application of the measurements on a prototype PPD-CIS chip with an array of 160 × 160 pixels is demonstrated. Such a method intends to shine new light on the guidance for the lag-free and high-speed sensors optimization based on PPD devices.
- 1 May 2016
- Published by IOP Publishing in Journal of Semiconductors
- Vol. 37 (5) , 054007
Measurement of charge transfer potential barrier in pinned photodiode CMOS image sensors
The charge transfer potential barrier (CTPB) formed beneath the transfer gate causes a noticeable image lag issue in pinned photodiode (PPD) CMOS image sensors (CIS), and is difficult to measure straightforwardly since it is embedded inside the device. From an understanding of the CTPB formation mechanism, we report on an alternative method to feasibly measure the CTPB height by performing a linear extrapolation coupled with a horizontal left-shift on the sensor photoresponse curve under the steady-state illumination. The theoretical study was performed in detail on the principle of the proposed method. Application of the measurements on a prototype PPD-CIS chip with an array of 160 × 160 pixels is demonstrated. Such a method intends to shine new light on the guidance for the lag-free and high-speed sensors optimization based on PPD devices.
- Open Access
- 15 April 2015
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Journal of the Electron Devices Society
- Vol. 3 (4) , 306-310
An Improved Model for the Full Well Capacity in Pinned Photodiode CMOS Image Sensors
An improved analytical model for quantifying the full well capacity in pinned photodiode (PPD) CMOS image sensors is proposed. The model captures the characteristics of the realistic technology-induced vertical doping nonuniformity in photon sensing N-type area of the PPD structure and the voltage dependency of the PPD capacitance, respectively, both of which were neglected in the existing works. Excellent agreement between measured and predicted data shows that the proposed model fits a wider range of technology conditions for a wider spectra responding compared to the up-to-date reported model.
- 15 April 2015
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Journal of the Electron Devices Society
- Vol. 3 (4) , 306-310
Open AccessAn Improved Model for the Full Well Capacity in Pinned Photodiode CMOS Image Sensors
An improved analytical model for quantifying the full well capacity in pinned photodiode (PPD) CMOS image sensors is proposed. The model captures the characteristics of the realistic technology-induced vertical doping nonuniformity in photon sensing N-type area of the PPD structure and the voltage dependency of the PPD capacitance, respectively, both of which were neglected in the existing works. Excellent agreement between measured and predicted data shows that the proposed model fits a wider range of technology conditions for a wider spectra responding compared to the up-to-date reported model.
- 28 November 2014
- Published by IOP Publishing in Chinese Physics B
- Vol. 23 (12) , 124215
A quantum efficiency analytical model for complementary metal—oxide—semiconductor image pixels with a pinned photodiode structure
- 28 November 2014
- Published by IOP Publishing in Chinese Physics B
- Vol. 23 (12) , 124215
A quantum efficiency analytical model for complementary metal—oxide—semiconductor image pixels with a pinned photodiode structure
- 1 November 2014
- Published by IOP Publishing in Journal of Semiconductors
- Vol. 35 (11) , 114009
Photoelectric characteristics of an inverse U-shape buried doping design for crosstalk suppression in pinned photodiodes
- 1 November 2014
- Published by IOP Publishing in Journal of Semiconductors
- Vol. 35 (11) , 114009
Photoelectric characteristics of an inverse U-shape buried doping design for crosstalk suppression in pinned photodiodes
- 1 July 2014
- Published by IOP Publishing in Journal of Semiconductors
- Vol. 35 (7)
Pinch-off voltage modeling for CMOS image pixels with a pinned photodiode structure
- 1 July 2014
- Published by IOP Publishing in Journal of Semiconductors
- Vol. 35 (7)
Pinch-off voltage modeling for CMOS image pixels with a pinned photodiode structure