Yifan Xu

Moderate flavone intake was non-linearly associated with a lower risk of incident psoriasis in the UK Biobank, whereas no significant associations were observed for other flavonoid subclasses.

Biomarkers of food intake (BFIs) can improve dietary assessment by providing objective measures of intake, yet no validated specific biomarkers are currently available for blueberries. In a randomized, controlled, crossover feeding study, 20 healthy young adults completed a 2-day run-in and then consumed fresh blueberries with standard meals (390 g on day 3; 780 g on day 4). Urine samples were collected at fasting, postprandial, and follow-up time points. Using untargeted dual-column ultrahigh-performance liquid chromatography–high-resolution mass spectrometry (UHPLC-HRMS) metabolomics, together with a multistage feature selection pipeline and analysis of fruit and in vitro digested samples, we identified 28 candidate BFIs, including novel metabolites such as 4-hydroxy-3-prenylbenzaldehyde and kirenol. XGBoost models showed that a three-compound panel comprising 4-hydroxy-3-prenylbenzaldehyde, kirenol, and p-coumaric acid-4-O-glucoside best predicted recent blueberry intake (AUC 0.81) beyond 24 h after intake and showed good specificity relative to other fruits. These findings support further development of BFIs for blueberry intake.

Title: Associations between dietary patterns and psoriasis risk: a prospective cohort study from the UK Biobank Background Psoriasis is an inflam | POSTER

Psoriasis is a chronic, inflammatory skin condition characterized by red, scaly patches that can cause substantial discomfort and social stigma ( | POSTER

Background: Diet is an important modifiable lifestyle factor for human health, and plant-rich dietary patterns are associated with lower risk of non-communicable diseases in numerous studies. However, objective assessment of plant-rich dietary exposure in nutritional epidemiology remains challenging. Objectives: This study aimed to develop and evaluate metabolic signatures of the most widely used plant-rich dietary patterns using a targeted metabolomics method comprising 108 plant food metabolites. Methods: A total of 218 healthy participants were included, aged 51.5 ± 17.7 years, with 24 h urine samples measured using ultra-high-performance liquid chromatography–mass spectrometry. The validation dataset employed three sample types to test the robustness of the signature, including 24 h urine (n = 88), plasma (n = 195), and spot urine (n = 198). Adherence to the plant-rich diet was assessed using a priori plant-rich dietary patterns calculated using Food Frequency Questionnaires. A combination of metabolites evaluating the adherence to a specific diet was identified as metabolic signature. We applied linear regression analysis to select the metabolites significantly associated with dietary patterns (adjusting energy intake), and ridge regression to estimate penalized weights of each candidate metabolite. The correlation between metabolic signature and the dietary pattern was assessed by Spearman analysis (FDR < 0.05). Results: The metabolic signatures consisting of 42, 22, 35, 15, 33, and 33 predictive metabolites across different subclasses were found to be associated with adherence to Amended Mediterranean Score (A-MED), Original MED (O-MED), Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), healthy Plant-based Diet Index (hPDI) and unhealthy PDI (uDPI), respectively. The overlapping and distinct predictive metabolites across six dietary patterns predominantly consisted of phenolic acids (n = 38), including 14 cinnamic acids, 14 hydroxybenzoic acids, seven phenylacetic acids, and three hippuric acids. Six metabolites were included in all signatures, including two lignans: enterolactone-glucuronide, enterolactone-sulfate, and four phenolic acids: cinnamic acid, cinnamic acid-4’-sulfate, 2’-hydroxycinnamic acid, and 4-methoxybenzoic acid-3-sulfate. The established signatures were robustly correlated with dietary patterns in the validation datasets (r = 0.13–0.40, FDR < 0.05). Conclusions: We developed and evaluated a set of metabolic signatures that reflected the adherence to plant-rich dietary patterns, suggesting the potential of these signatures to serve as an objective assessment of free-living eating habits.

Development of a novel Food Frequency Questionnaire (FFQ) to capture dietary (poly)phenol intake. The new FFQ showed fair to strong validity against 7-day diet diaries and plasma and urinary poly)phenol metabolites, suggesting it is a promising tool for assessing (poly)phenol intake in the UK.

(Poly)phenol intake has been associated with reduced risk of non-communicable diseases in epidemiological studies 1,2. However, there are no diet | POSTER