Sébastien Bougleux

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a median overall survival of 15 months. Longitudinal, multi-modal imaging datasets with comprehensive clinical and treatment data are essential to support the development of reproducible computational methods for treatment response prediction, disease progression modelling, and personalized medicine. We present CFB-GBM v2.0, an extension of our previously released CFB-GBM dataset comprising 264 GBM patients treated according to the standard Stupp protocol. The primary contribution of this release is the completion of Gross Tumour Volume (GTV) delineations across all available timepoints (t0 , t1 and t2 ), increasing the overall GTV completion rate from 35% to 97%. This was achieved using a nnU-Net model pre-trained on BraTS 2021 and fine-tuned on CFB-GBM ground-truth contours, with the generated segmentations validated by five radiation oncologists. From these longitudinal GTV annotations, volumetric RANO 2.0 response category labels were derived for all available temporality pairs (t0 → t1 , t0 → t2 and t1 → t2 ). To further ease dataset usability and reproducibility, brain masks computed with HD-BET and pre-computed radiomic features extracted with PyRadiomics are provided for each patient timepoint and MRI modality. Additionally, the WHO classification guideline (2016 vs. 2021) applicable to each patient’s diagnosis is now explicitly documented. CFB-GBM v2.0 is publicly available on The Cancer Imaging Archive (TCIA) at www.cancerimagingarchive.net/collection/cfb-gbm

3D meshes are fundamental data representations for capturing complex geometric shapes in computer vision and graphics applications. While Convolutional Neural Networks (CNNs) have excelled in structured data like images, extending them to irregular 3D meshes is challenging due to the non-Euclidean nature of the data. Graph Convolutional Networks (GCNs) offer a solution by applying convolutions to graph-structured data, but many existing methods rely on isotropic filters or spectral decomposition, limiting their ability to capture both local and global mesh features. In this paper, we introduce 3D Geometric Mesh Network (3DGeoMeshNet), a novel GCN-based framework that uses anisotropic convolution layers to effectively learn both global and local features directly in the spatial domain. Unlike previous approaches that convert meshes into intermediate representations like voxel grids or point clouds, our method preserves the original polygonal mesh format throughout the reconstruction process, enabling more accurate shape reconstruction. Our architecture features a multi-scale encoder-decoder structure, where separate global and local pathways capture both large-scale geometric structures and fine-grained local details. Extensive experiments on the COMA dataset containing human faces demonstrate the efficiency of 3DGeoMeshNet in terms of reconstruction accuracy.

With the advent of whole slide image (WSI) scanners, pathology is undergoing a digital revolution. Simultaneously, with the development of image analysis algorithms based on artificial intelligence tools, the application of computerized WSI analysis can now be expected. However, transferring such tools into clinical practice is very challenging as they must deal with many artifacts that can occur during sample preparation and digitization. Therefore, the quality of WSIs is of prime importance, and we propose a review of the state-of-the-art of computational approaches for quality control. In particular, we focus on WSI quality issues related to the presence of sample preparation artifacts, compression artifacts, color variations, and out-of-focus areas. An analysis of the monthly WSI clinical routine in a cytological laboratory confirms the importance of implementing quality control measures. Given this observation, we draw perspectives on how a computational quality process can be included in a computational pathology diagnosis pipeline.