Jihwan Park
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Jihwan Park has a total of 439 co-authors. Here are the top co-authors by number of shared publications:
- Katalin Susztak
University of Pennsylvania
22 shared publications - Andrew J. Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
21 shared publications - Baekgyu Choi
Korea Advanced Institute of Science and Technology (KAIST) 1 Department of Biological Sciences Daejeon, Republic of Korea
21 shared publications - Chul-Hwan Lee
Seoul National University
21 shared publications - Gou Young Koh
Center for Vascular Research, Institute for Basic Science and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
21 shared publications - Gyeong Hoon Kang
Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
21 shared publications
Latest Publications
- Open Access
- 3 September 2026
- Published by Springer Nature in Experimental & Molecular Medicine
- Vol. 58 (9) , 2972-2989
Generation of the functionally enhanced proximal tubular cells from human iPSC-derived kidney organoids
Human renal proximal tubular epithelial cells (RPPTCs) are crucial for exploring the molecular and cellular mechanisms underlying the pathophysiology of kidney injuries. In this study, we generated the functionally enhanced kidney organoid-derived proximal tubule cells (FEKOPTCs) from human induced pluripotent stem cells. Heparan sulfate proteoglycans and transforming growth factor-β receptor inhibitor enhanced the functionality of PTCs isolated from the kidney organoids of which the vascularization and maturation were improved by heparan sulfate proteoglycans and vascular endothelial growth factor. FEKOPTCs showed significantly enhanced epithelial barrier function, polarization state, and transporter function, compared with primary human RPTECs, which led to improve the function of drug uptake. Transcriptomic characterization of FEKOPTCs revealed high similarity to PTCs of native human adult kidney. FEKOPTCs-on-chip are more sensitive predictors than RPTECs-on-chip for nephrotoxicity testing. By using CRISPR−Cas9 genetic mutation of alpha-galactosidase A, the causative gene of Fabry disease, alpha-galactosidase A-mutant FEKOPTCs, recapitulated the functional phenotype of Fabry disease. When FEKOPTCs were transplanted into the kidney parenchyma of NOD-SCID mice, they reassembled and regenerated proximal tubular structures with intact lumens and functional transporters. Taken together, our results suggest that FEKOPTCs are functionally enhanced PTCs and can be applied for nephrotoxicity testing, disease modeling, and regenerative medicine.
- 3 September 2026
- Published by Springer Nature in Experimental & Molecular Medicine
- Vol. 58 (9) , 2972-2989
Open AccessGeneration of the functionally enhanced proximal tubular cells from human iPSC-derived kidney organoids
Human renal proximal tubular epithelial cells (RPPTCs) are crucial for exploring the molecular and cellular mechanisms underlying the pathophysiology of kidney injuries. In this study, we generated the functionally enhanced kidney organoid-derived proximal tubule cells (FEKOPTCs) from human induced pluripotent stem cells. Heparan sulfate proteoglycans and transforming growth factor-β receptor inhibitor enhanced the functionality of PTCs isolated from the kidney organoids of which the vascularization and maturation were improved by heparan sulfate proteoglycans and vascular endothelial growth factor. FEKOPTCs showed significantly enhanced epithelial barrier function, polarization state, and transporter function, compared with primary human RPTECs, which led to improve the function of drug uptake. Transcriptomic characterization of FEKOPTCs revealed high similarity to PTCs of native human adult kidney. FEKOPTCs-on-chip are more sensitive predictors than RPTECs-on-chip for nephrotoxicity testing. By using CRISPR−Cas9 genetic mutation of alpha-galactosidase A, the causative gene of Fabry disease, alpha-galactosidase A-mutant FEKOPTCs, recapitulated the functional phenotype of Fabry disease. When FEKOPTCs were transplanted into the kidney parenchyma of NOD-SCID mice, they reassembled and regenerated proximal tubular structures with intact lumens and functional transporters. Taken together, our results suggest that FEKOPTCs are functionally enhanced PTCs and can be applied for nephrotoxicity testing, disease modeling, and regenerative medicine.
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Figure S8 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Characterization of integrin αv regulation in TECs and EC progenitors
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessFigure S8 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Characterization of integrin αv regulation in TECs and EC progenitors
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Table S4 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of stage-specific cCREs across vascular EC development from hESCs
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessTable S4 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of stage-specific cCREs across vascular EC development from hESCs
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Table S3 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of stage-specific genes across vascular EC development from hESCs
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessTable S3 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of stage-specific genes across vascular EC development from hESCs
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Figure S5 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Transcriptomic landscape profiling of hESC-EC differentiation
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessFigure S5 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Transcriptomic landscape profiling of hESC-EC differentiation
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Table S2 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of TEC-specific cCREs across vascular EC subtypes from colorectal tumors
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessTable S2 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of TEC-specific cCREs across vascular EC subtypes from colorectal tumors
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Figure S6 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
H3K27ac landscape profiling of hESC-EC differentiation
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessFigure S6 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
H3K27ac landscape profiling of hESC-EC differentiation
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Figure S7 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Evaluation of genome-wide 3D chromatin contact profiles of vascular EC progenitors
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessFigure S7 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Evaluation of genome-wide 3D chromatin contact profiles of vascular EC progenitors
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Table S1 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of TEC-specific genes across vascular EC subtypes from cross-cancer scRNA-seq data
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessTable S1 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
List of TEC-specific genes across vascular EC subtypes from cross-cancer scRNA-seq data
- Open Access
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Figure S2 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Identification of TEC-specific gene expression and its association with clinical outcomes
- 2 September 2026
- Published by American Association for Cancer Research (AACR)
Open AccessFigure S2 from A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes
Identification of TEC-specific gene expression and its association with clinical outcomes