Rajesh Kumar

Large language models (LLMs) are beginning to reshape how chemists plan and run reactions in organic synthesis. Trained on millions of reported transformations, these text-based models can propose synthetic routes, forecast reaction outcomes and even instruct robots that execute experiments without human supervision. Here we survey the milestones that turned LLMs from speculative tools into practical lab partners. We show how coupling LLMs with graph neural networks, quantum calculations and real-time spectroscopy shrinks discovery cycles and supports greener, data-driven chemistry. We discuss limitations, including biased datasets, opaque reasoning and the need for safety gates that prevent unintentional hazards. Finally, we outline community initiatives open benchmarks, federated learning and explainable interfaces that aim to democratize access while keeping humans firmly in control. These advances chart a path towards rapid, reliable and inclusive molecular innovation powered by artificial intelligence and automation.

The rapid growth of medical imaging data presents significant challenges in diagnostic accuracy, data privacy, and computational efficiency. Traditional centralized AI models struggle with scalability and pose risks to patient confidentiality due to data aggregation. Moreover, heterogeneous medical data across institutions complicates the development of robust diagnostic tools. To address these issues, we propose MID-LLM, a novel framework that integrates Large Language Models (LLMs) with a blockchain-based federated learning system for medical image analysis. It also ensures the security and privacy of sensitive medical data across decentralized networks. MID-LLM uses verification mechanisms to ensure the global model’s integrity. It also employs aggregation techniques to reduce bias and improve training efficiency. Experiments on the BraTS 2020 dataset show that MID-LLM outperforms traditional federated learning, achieving higher Dice scores with improved computational efficiency. These results highlight MID-LLM’s potential to enhance diagnostic accuracy while offering a scalable, secure solution for AI in healthcare.

The secure and efficient storage and sharing of medical images have become increasingly important due to rising security threats and performance limitations in existing healthcare systems. Centralized systems struggle to provide adequate privacy, rapid access, and reliable storage for sensitive medical images. This paper proposes a decentralized medical image-sharing framework to address these issues by integrating blockchain technology, the InterPlanetary File System (IPFS), and edge computing. Blockchain technology enforces secure patient-centric access control through smart contracts that enable patients to directly manage their data-sharing permissions. The IPFS provides decentralized and scalable storage for medical images and effectively resolves the storage limitations associated with blockchain. Edge computing enhances system responsiveness by significantly reducing latency through local data processing to ensure timely medical image access. Robust security is ensured by using elliptic curve cryptography (ECC) for secure key management and the Advanced Encryption Standard (AES) for encrypting medical images to protect against unauthorized access and data breaches. Additionally, the system includes real-time monitoring to promptly detect and respond to unauthorized access attempts to ensure continuous protection against potential security threats. System results demonstrate that the proposed framework achieves lower latency, higher throughput, and improved security compared to traditional centralized storage solutions, which makes our system suitable for practical deployment in modern healthcare settings.

This paper presents a comprehensive study of 3D point cloud Federated Few-Shot Learning (3DFFL), focusing on addressing challenges such as limited data availability and privacy concerns in point cloud classification for applications such as autonomous vehicles. We introduce a novel approach that integrates Federated Learning with Few-Shot Learning techniques, with a special emphasis on optimizing network architectures for 3D point cloud data. Our method capitalizes on the strengths of PointNet++ for feature extraction and ProtoNet for classification, all within a federated learning framework to ensure data privacy and collaborative learning. Significantly, the approach is augmented with the use of attention and SoftMax layers, enhancing the feature extraction and classification processes. Extensive experiments on the ModelNet40, ShapeNet, and ScanOnjectNN datasets validate our method’s accuracy and adaptability in handling 3D point cloud classification, especially in privacy-sensitive and collaborative scenarios. This study not only demonstrates the potential of integrating attention mechanisms and SoftMax layers in 3DFFL but also lays a robust foundation for future advancements in this evolving field, particularly in technologies dependent on 3D data processing.

Privacy and trust are highly demanding in practical recommendation engines. Although Federated Learning (FL) has significantly addressed privacy concerns, commercial operators are still worried about several technical challenges while bringing FL into production. In addition, classical FL has several intrinsic operational limitations such as single-point failure, data and model tampering, and heterogenic clients participating in the FL process. To address these challenges in practical recommenders, we propose a responsible recommendation generation framework based on blockchain-empowered asynchronous FL that can be adopted for any model-based recommender system. In standard FL settings, we build an additional aggregation layer in which multiple trusted nodes guided by a mediator component perform gradient aggregation to achieve an optimal model locally in a parallel fashion. The mediator partitions users into K clusters, and each cluster is represented by a cluster head. Once a cluster gets semi-global convergence, the cluster head transmits model gradients to the FL server for global aggregation. In addition the trusted cluster heads are responsible to submit the converged semi-global model to a blockchain to ensure tamper resilience. In our settings, an additional mediator component works like an independent observer that monitors the performance of each cluster head, updates a reward score, and records it into a digital ledger. Finally, evaluation results on three diversified benchmarks illustrate that the recommendation performance on selected measures is considerably comparable with the standard and federated version of a well-known neural collaborative filtering recommender.

The multilabel learning task aims to predict the associated multiple classes of a given example simultaneously. Such task becomes more challenging when data arrives in stream since it requires concept drift adaptative, robust, and fast algorithm. In this article, we present an online semi-supervised classification algorithm (OSMTS) for multilabel text streams. By leveraging a few labeled instances, OSMTS dynamically maintains the subspace of terms for each label with a set of evolving micro-clusters. For multilabel classification, $k$ nearest micro-clusters are employed for prediction by using a nonparametric Dirichlet model. To handle the gradual concept drift in term space, the triangular time function is adopted to calculate the difference between term arriving time and cluster life span. Whereas, abrupt concept drift is dealt by considering two procedures: 1) deleting outdated micro-cluster by exploiting the exponential decay function and 2) creating new micro-clusters by adopting the Chinese restaurant process based on the Dirichlet process. The conducted experimental study provides a comparison with 12 state-of-the-art algorithms on nine datasets in terms of classification performance, runtime, and memory consumption.