Pengfei Yan

The heteropolynuclear chiral tetrahedral cages (Yb/Eu) ₄ L ₄ ( R / S -BINAPO) ₄ exhibit upconverted circularly polarized luminescence (UC-CPL) via a novel Yb** → T ₁ → Eu* upconversion luminescence mechanism.

The assembly shows the structural transformation from a multiple species mixture Eu₂(LR)_2n to a helicate Eu₂(LR)₄ upon increasing the content of CHCl₃ in CH₃CN, which was accompanied by an enhanced CPL activity.

The mononuclear Eu³⁺ complexes show solvent and Cs⁺ ion cooperatively induced metal stereocenter Δ/Λ configurational inversion, accompanied by an inversion of the circularly polarized luminescence sign.

The dinuclear helicate Eu ₂ (LR) ₄ exhibits a solvent-regulated metal stereocenter Δ/Λ configurational inversion, independent of P / M helical conformational conversion. This reversal process is accompanied by an inversion of the CPL.

Chiral BINOL-modified dinuclear helicates Yb ₂ ( R / S -BTHP) ₄ show the excellent NIR-CPL at 980 nm with the g _lum reaching up to 0.81 and B _CPL being up to 821 M ⁻¹ cm ⁻¹ .

A chiral guanidine cation as a counterion of a double decker sandwich europium( iii ) complex, [Eu L ₂ ] ⁻ , breaks the racemization equilibrium of assemblies and induces circularly polarized emission from Eu ³⁺ ions.

In this study, a tumor-targeting and pH-sensitive inclusion complex based on the host-guest recognition between the chitosan and folic acid grafted HP-β-CD (FA-CS-CD) and stearic acid modified 2-benzimidazolemethanol (BM-SA) was designed and fabricated for the controlled delivery of paclitaxel (PTX). Through the combination of computational simulations and experiments, the interaction between FA-CS-CD, BM-SA, and PTX was investigated, and the optimized preparation method was obtained. For the optimized PTX-loaded FA-CS-CD/BM-SA inclusion complex, the particle size and zeta potential were 146 nm and +15.4 mV, respectively. In vitro drug release study revealed the pH-triggered drug release behavior of the inclusion complex. Both in vitro and in vivo evaluations demonstrated that the PTX-loaded FA-CS-CD/BM-SA inclusion complex exhibited enhanced antitumor efficiency and minimized systemic toxicity. This system might be a promising carrier for PTX.

Undoubtably, it is challenging to simultaneously determine the identity, enantiomeric excess (ee), and total concentration of an enantiomer by just one optical measurement. Herein, we design a chiral tetrahedron Eu₄(L^R)₄ with circularly polarized luminescence (CPL), which presents highly selective/stereoselective, rapid, and "turn-on" CPL response to chiral diamines, rather than the monoamino compounds, such as monoamines or amino alcohols. By recording the left- and right-CPL intensities of the Eu³⁺ ion at 591 nm, the enantiomeric composition and concentration of chiral diamines can be simultaneously determined by monitoring the g_lum value and total emission intensity (I_L + I_R), respectively. Spectroscopy analyses demonstrate that the variations of g_lum depend on the inversion and maintenance of configuration around the Eu³⁺ ion (Δ ↔ Λ), while the "turn-on" response arises from the raising of the T₁ state of the ligand. The molecule/electron structural variations are proposed from the synergetic supramolecular interactions of NH₂ groups with pendant diols and trifluoroacetyl groups.

In the present study, an amphiphilic polymer was prepared by conjugating methoxy poly(ethylene glycol) (mPEG) with tetraphenylethene (TPE) via disulfide bonds (Bi(mPEG-S-S)-TPE). The polymer could self-assemble into micelles and solubilize hydrophobic anticancer drugs such as paclitaxel (PTX) in the core. Combining the effect of TPE, mPEG, and disulfide bonds, the Bi(mPEG-S-S)-TPE micelles exhibited excellent AIE feature, reduced protein adsorption, and redox-sensitive drug release behavior. An in vitro intracellular uptake study demonstrated the great imaging ability and efficient internalization of Bi(mPEG-S-S)-TPE micelles. The excellent anticancer effect and low systemic toxicity were further evidenced by the in vivo anticancer experiment. The Bi(mPEG-S-S)-TPE micelles were promising drug carriers for chemotherapy and bioimaging.