Anjalika Pathirana
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Anjalika Pathirana has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Deli Hays
Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao 266003, China
1 shared publication - Qiyu Xu
Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China
1 shared publication - Shibo Huang
Department of Marine Biology, Institute of Evolution and Marine Biodiversity and College of Marine Life Science, Ocean University of China, Qingdao 266003, China
1 shared publication - Shicui Zhang
College of Life and Geographic Sciences, Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, Kashi University, Kashi, China
1 shared publication - Yujun Liang
MoE Key Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, College of Marine Life Sciences, Ocean University of China, Qingdao, China
1 shared publication
Latest Publications
- 15 February 2019
- Published by The Company of Biologists in Development
- Vol. 146 (4) , dev.166017
BMP signaling is required for amphioxus tail regeneration
Amphioxus, a cephalochordate, is an ideal animal to address the questions about the evolution of regenerative ability and mechanisms behind the invertebrate to vertebrate transition in chordates. However, the cellular and molecular basis of tail regeneration in amphioxus remains largely ill-defined. We confirmed that the tail regeneration of amphioxus Branchiostoma japonicum is a vertebrate-like epimorphosis process. We performed transcriptome analysis of the tail regenerates, which provided many clues for exploring the mechanism of tail regeneration. Importantly, we showed that BMP2/4 and its related signaling are essential for the process of tail regeneration, revealing an evolutionarily conserved genetic regulatory system involved in regeneration in many metazoans. We serendipitously discovered that, bmp2/4 expression is immediately inducible by general wounds and that the expression of bmp2/4 can be regarded as a biomarker of wounds in amphioxus. Collectively, our results provide a framework for understanding the evolution and diversity of cellular and molecular events of tail regeneration in vertebrates.
- 15 February 2019
- Published by The Company of Biologists in Development
- Vol. 146 (4) , dev.166017
BMP signaling is required for amphioxus tail regeneration
Amphioxus, a cephalochordate, is an ideal animal to address the questions about the evolution of regenerative ability and mechanisms behind the invertebrate to vertebrate transition in chordates. However, the cellular and molecular basis of tail regeneration in amphioxus remains largely ill-defined. We confirmed that the tail regeneration of amphioxus Branchiostoma japonicum is a vertebrate-like epimorphosis process. We performed transcriptome analysis of the tail regenerates, which provided many clues for exploring the mechanism of tail regeneration. Importantly, we showed that BMP2/4 and its related signaling are essential for the process of tail regeneration, revealing an evolutionarily conserved genetic regulatory system involved in regeneration in many metazoans. We serendipitously discovered that, bmp2/4 expression is immediately inducible by general wounds and that the expression of bmp2/4 can be regarded as a biomarker of wounds in amphioxus. Collectively, our results provide a framework for understanding the evolution and diversity of cellular and molecular events of tail regeneration in vertebrates.