Alicia Martin
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Alicia Martin has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Jennifer Schiller
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
1 shared publication - Jennifer Yee
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
1 shared publication - Johnny C. Hong
Department of Solid Organ Transplantation and Hepatobiliary Surgery, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH 43608, USA
1 shared publication - Michael A. Zimmerman
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
1 shared publication
Latest Publications
- Open Access
- 1 April 2017
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 6 (4) , 41
Natural Killer T Cells in Liver Ischemia–Reperfusion Injury
Restoration of blood flow to an ischemic organ results in significant tissue injury. In the field of liver transplantation, ischemia–reperfusion injury (IRI) has proven to be a formidable clinical obstacle. In addition to metabolic stress and inflammation, IRI results in profound graft dysfunction and loss. The severity of IRI further limits the ability to expand the donor pool by using partial grafts and marginal organs. As such, the inflammatory response to reperfusion of the liver continues to be an area of intense investigation. Among the various leukocytes involved in IRI, new insights suggest that natural killer T (NKT) cells may be a central driver of hepatocellular injury. Herein, we examine recent experimental observations that provide a mechanistic link between NKT cell recruitment to liver and post-perfusion tissue injury.
- 1 April 2017
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 6 (4) , 41
Open AccessNatural Killer T Cells in Liver Ischemia–Reperfusion Injury
Restoration of blood flow to an ischemic organ results in significant tissue injury. In the field of liver transplantation, ischemia–reperfusion injury (IRI) has proven to be a formidable clinical obstacle. In addition to metabolic stress and inflammation, IRI results in profound graft dysfunction and loss. The severity of IRI further limits the ability to expand the donor pool by using partial grafts and marginal organs. As such, the inflammatory response to reperfusion of the liver continues to be an area of intense investigation. Among the various leukocytes involved in IRI, new insights suggest that natural killer T (NKT) cells may be a central driver of hepatocellular injury. Herein, we examine recent experimental observations that provide a mechanistic link between NKT cell recruitment to liver and post-perfusion tissue injury.