Joo-Hye Song

Classification of thymic epithelial tumors into three subgroups using PCA, k-means clustering, and NMF, along with correlations between non-tumor cell proportions and T cell markers

Characteristics of 137 thymic epithelial tumors, including clinical data, genomic alterations, and transcriptional signatures

Differential expression of lipid metabolism genes between GTF2I-type and CN-type thymomas is shown through box plots and scatter plots, revealing consistent expression differences not biased by tumor cell fraction and indicating that these transcripts originate mainly from tumor cells

IRS4's high expression in certain thymoma types, its tissue distribution, cellular expression patterns, regulatory associations, prognostic significance, and the presence of a cryptic exon influencing IRS4 transcripts

Validation of thymic epithelial tumor subgroups using single-cell RNA-seq data, including UMAP projections, gene expression heatmaps, inferred copy-number alterations, and mapping onto the normal TECs

List of gene sets used in immune component analysis

List of datasets used in single-cell RNA-seq analysis

Correlation between IRS4 expression levels and pathway scores using Pearson, Spearman, and linear regression with tumor cell fraction

Immune profiles of thymic epithelial tumors, highlighting the correlation between non-tumor cell proportions and thymopoiesis scores, with significant contributions from thymopoiesis and TET subgroups, and demonstrates differences in immune and B cell scores across tumor types and clinical histories

Results of pathological reviews related to plasma cells and tertiary lymphoid structures