Amrita Mukherjee
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Amrita Mukherjee has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Carlo Ng Giachello
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
1 shared publication- Khomgrit Morarach
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
1 shared publication - Maarten Frans Zwart
School of Psychology and Neuroscience, Centre of Biophotonics, University of St Andrews, St Andrews, United Kingdom
1 shared publication - Matthew C. W. Oswald
Department of Zoology, University of Cambridge
1 shared publication - Matthias Landgraf
Department of Zoology, University of Cambridge
1 shared publication - Paul S. Brooks
University of Cambridge
1 shared publication
Latest Publications
- Open Access
- 17 December 2018
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 7
Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila
Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1β as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.
- 17 December 2018
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 7
Open AccessReactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila
Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1β as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.