Yuxia Yao
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Research Interests
Yuxia Yao has a total of 17 co-authors. Here are the top co-authors by number of shared publications:
- Hock Beng Lim
Faculty of Arts and Social Science, Psychology National University of Singapore Singapore
2 shared publications Mudasser Iqbal
Intell. Syst. Center, Nanyang Technol. Univ., Singapore, Singapore
2 shared publications- Bangwei Cao
Cancer Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China
1 shared publication Bao-Hong Xu
Department of Digestive Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China
1 shared publication- Boyang Li
College of Computing and Data Science, Nanyang Technological University, Singapore, Singapore
1 shared publication Chen-Guang Zhang
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
1 shared publication
Latest Publications
- Open Access
- 4 November 2018
- Published by Wiley in BioMed Research International
- Vol. 2018, 1-8
CX-3543 Promotes Cell Apoptosis through Downregulation of CCAT1 in Colon Cancer Cells
Aim. Colon cancer-associated transcript-1 (CCAT1), located in the vicinity of transcription factor c-Myc, was first identified in colon cancer. A small-molecule compound CX3543 (Quarfloxin) selectively targeting Myc G-quadruplexes has entered phase II clinical trials for neuroendocrine carcinomas. The aim of the study was to explore the relationship between CX3543, CCAT1, and cell apoptosis in colon cancer cells. Methods. Semiquantitative PCR was used to detect the relative expression of CCAT1 in colon cancer (CC) tissues and HT29 cell lines. Real-time PCR (RT-PCR) was also used to investigate the expression of CCAT1 and c-Myc after HT29 cells being treated by CX3543 for 24 h. Cell apoptosis assay and cell proliferation assay were conducted in HT29 cells after being treated by CX3543. Results. The results showed that the expression of CCAT1 was remarkably increased in CC tissues and HT29 cells compared to controls. CX3543 treatment reduced the expression of c-Myc and CCAT1 and promoted cell apoptosis and inhibited cell proliferation. After the expression of CCAT1 was inhibited by sh-CCAT1 transfection, the cell apoptosis rate was higher than that of control group. After the cells were treated by CCAT1 overexpression plasmid transfection and CX3543, the cell apoptosis rate was lower than that of control group. In vivo results showed that CX3543 inhibited the xenograft tumor growth of rats through downregulation of CCAT1. Conclusion. Our study demonstrated that CX3543 could inhibit the progression of colon cancer by downregulating CCAT1 expression and might be a potential drug for the treatment of colon cancer.
- 4 November 2018
- Published by Wiley in BioMed Research International
- Vol. 2018, 1-8
Open AccessCX-3543 Promotes Cell Apoptosis through Downregulation of CCAT1 in Colon Cancer Cells
Aim. Colon cancer-associated transcript-1 (CCAT1), located in the vicinity of transcription factor c-Myc, was first identified in colon cancer. A small-molecule compound CX3543 (Quarfloxin) selectively targeting Myc G-quadruplexes has entered phase II clinical trials for neuroendocrine carcinomas. The aim of the study was to explore the relationship between CX3543, CCAT1, and cell apoptosis in colon cancer cells. Methods. Semiquantitative PCR was used to detect the relative expression of CCAT1 in colon cancer (CC) tissues and HT29 cell lines. Real-time PCR (RT-PCR) was also used to investigate the expression of CCAT1 and c-Myc after HT29 cells being treated by CX3543 for 24 h. Cell apoptosis assay and cell proliferation assay were conducted in HT29 cells after being treated by CX3543. Results. The results showed that the expression of CCAT1 was remarkably increased in CC tissues and HT29 cells compared to controls. CX3543 treatment reduced the expression of c-Myc and CCAT1 and promoted cell apoptosis and inhibited cell proliferation. After the expression of CCAT1 was inhibited by sh-CCAT1 transfection, the cell apoptosis rate was higher than that of control group. After the cells were treated by CCAT1 overexpression plasmid transfection and CX3543, the cell apoptosis rate was lower than that of control group. In vivo results showed that CX3543 inhibited the xenograft tumor growth of rats through downregulation of CCAT1. Conclusion. Our study demonstrated that CX3543 could inhibit the progression of colon cancer by downregulating CCAT1 expression and might be a potential drug for the treatment of colon cancer.
- Open Access
- 3 June 2018
- Published by Wiley in Journal of Immunology Research
- Vol. 2018, 1-9
Risk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis
We performed a systematic review and meta-analysis to determine the risk of immune-related pancreatitis associated with the treatment by immune checkpoint inhibitors (ICIs) for solid tumors. Eligible studies were selected from multiple databases including phase II/III randomized controlled trials (RCTs) with ICIs in solid tumor patients. The data were analyzed with Stata version 12.0 software. After excluding ineligible studies, a total of 15 clinical trials were considered eligible for the meta-analysis, which included 9099 patients. Compared with chemotherapy or placebo, the risk ratio (RR) for all-grade lipase elevation after CTLA-4 inhibitor treatment was 1.05 (95% confidence interval (CI): 1.01–2.24, ). However, the risk for pancreatitis after ICI treatment in any subgroup was not significantly higher than that after control therapy. In addition, compared with ipilimumab/nivolumab alone, the RR for all-grade and high-grade lipase elevation under combination treatment of nivolumab and ipilimumab was 6.43 (95% CI: 1.43–28.99, ) and 6.44 (95% CI: 1.39–29.79, ), respectively, and the RR for all-grade amylase elevation under combination treatment was 6.08 (95% CI: 1.51–24.44, ). Our meta-analysis has demonstrated that both CTLA-4 inhibitors alone and combination treatment of nivolumab and ipilimumab could increase the risk of amylase or lipase elevation, but not significantly increase the risk of pancreatitis when compared with controls.- 3 June 2018
- Published by Wiley in Journal of Immunology Research
- Vol. 2018, 1-9
Open AccessRisk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis
We performed a systematic review and meta-analysis to determine the risk of immune-related pancreatitis associated with the treatment by immune checkpoint inhibitors (ICIs) for solid tumors. Eligible studies were selected from multiple databases including phase II/III randomized controlled trials (RCTs) with ICIs in solid tumor patients. The data were analyzed with Stata version 12.0 software. After excluding ineligible studies, a total of 15 clinical trials were considered eligible for the meta-analysis, which included 9099 patients. Compared with chemotherapy or placebo, the risk ratio (RR) for all-grade lipase elevation after CTLA-4 inhibitor treatment was 1.05 (95% confidence interval (CI): 1.01–2.24, ). However, the risk for pancreatitis after ICI treatment in any subgroup was not significantly higher than that after control therapy. In addition, compared with ipilimumab/nivolumab alone, the RR for all-grade and high-grade lipase elevation under combination treatment of nivolumab and ipilimumab was 6.43 (95% CI: 1.43–28.99, ) and 6.44 (95% CI: 1.39–29.79, ), respectively, and the RR for all-grade amylase elevation under combination treatment was 6.08 (95% CI: 1.51–24.44, ). Our meta-analysis has demonstrated that both CTLA-4 inhibitors alone and combination treatment of nivolumab and ipilimumab could increase the risk of amylase or lipase elevation, but not significantly increase the risk of pancreatitis when compared with controls. - 1 January 2012
- Published by Springer Nature
- p. 197-203
Application Research of Weighted Fuzzy C Means Clustering about Soil Fertility Evaluation in Nong’an County
- 1 January 2012
- Published by Springer Nature
- p. 197-203
Application Research of Weighted Fuzzy C Means Clustering about Soil Fertility Evaluation in Nong’an County
- 1 May 2009
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 395-400
A Service Oriented Model for Semantics-Based Data Management in Wireless Sensor Networks
The emerging heterogeneity of data management, programming models and operating platforms in sensor nodes are making the seamless interoperation of devices a challenge. We consider this problem and leverage on the concepts of semantic web and service-oriented design to propose a model that adds a semantics and service-oriented layer to existing network models. This added layer hides the hardware as well as software implementation details from the application layer and thus allows seamless data management between nodes whose capabilities may even be unknown. The proposed model builds on top of well established standards OWL and OWL-S to encapsulate sensor data and services as hierarchical ontology and provides interfaces for service advertisement and discovery. A case study has been discussed whereby the proposed model is used for service-oriented data management (acquisition, archival, processing).
- 1 May 2009
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 395-400
A Service Oriented Model for Semantics-Based Data Management in Wireless Sensor Networks
The emerging heterogeneity of data management, programming models and operating platforms in sensor nodes are making the seamless interoperation of devices a challenge. We consider this problem and leverage on the concepts of semantic web and service-oriented design to propose a model that adds a semantics and service-oriented layer to existing network models. This added layer hides the hardware as well as software implementation details from the application layer and thus allows seamless data management between nodes whose capabilities may even be unknown. The proposed model builds on top of well established standards OWL and OWL-S to encapsulate sensor data and services as hierarchical ontology and provides interfaces for service advertisement and discovery. A case study has been discussed whereby the proposed model is used for service-oriented data management (acquisition, archival, processing).
- Open Access
- 6 November 2007
- Published by Association for Computing Machinery (ACM)
- p. 369-370
The national weather sensor grid
- 6 November 2007
- Published by Association for Computing Machinery (ACM)
- p. 369-370
Open AccessThe national weather sensor grid