Wei Zhang

Background: Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships betweenMBL2polymorphisms and PTB.Methods: The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships.Results: There were 37 case-control studies examining the effects of the four SNPs inMBL2on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891.Conclusions: Our current study indicated that several SNPs inMBL2may be associated with susceptibility to PTB.

Background Interleukin-10 (IL-10) is considered to play a role in the human immunodeficiency virus-1 (HIV-1) infections, three common single nucleotide polymorphisms (SNPs), perhaps have an association with HIV-1 risk. Methods To find out the above doubt, a comprehensive study to evaluate the association between IL-10 polymorphisms and HIV-1 has been performed. PubMed database was chosen to identify potential articles through Feb 21, 2020. The odd ratio with 95% confidence interval (OR with 95%CI) was applied to evaluate the relationships. Results There have 15 different articles including 24 case-control studies including those on three different SNPs in IL-10 for HIV-1 were found. Positive increased or damaged associations were detected for rs1800872C/A with HIV-1 risk in total (such as: OR with 95%CI = 1.22 with 1.02–1.41 for A-allele vs. C-allele model), and Asians (such as: OR with 95%CI = 1.51 with 1.07–1.88 for AA vs. CC model), population-based, PCR-RFLP, sequence subgroups. Moreover, increased associations were also detected between rs1800871C/T SNP (OR with 95%CI = 1.47 with 1.08-2.00 for CC vs. CT + TT model). No association was found for rs1800896. Conclusion Our current study indicated that two SNPs (rs1800872C/A and rs1800871C/T) in IL-10 perhaps be potentially associated with the susceptibility for developing HIV-1 infection.

A single nucleotide polymorphism in the interferon-γ gene ( IFNG +874 T/A) is associated with susceptibility to tuberculosis