Yunjie Yang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Yunjie Yang has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Dan Song
Sun Yat-sen University
1 shared publication - Fangfang Qi
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
1 shared publication - Junhua Yang
Department of Anatomy, School of Basic Medical Sciences Guangdong Pharmaceutical University Guangzhou Guangdong China
1 shared publication - Juntao Zou
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
1 shared publication Kaihua Guo
Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan No. 2 Road, Guangzhou, 510080, China
1 shared publication- Qiongliang Liu
Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China
1 shared publication
Latest Publications
- Open Access
- 13 August 2018
- Published by Springer Nature in Journal of Neuroinflammation
- Vol. 15 (1) , 1-17
Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism
Prenatal infection is a substantial risk factor for neurodevelopmental disorders such as autism in offspring. We have previously reported that influenza vaccination (VAC) during early pregnancy contributes to neurogenesis and behavioral function in offspring. Here, we probe the efficacy of VAC pretreatment on autism-like behaviors in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) mouse model. We show that VAC improves abnormal fetal brain cytoarchitecture and lamination, an effect associated with promotion of intermediate progenitor cell differentiation in MIA fetal brain. These beneficial effects are sufficient to prevent social deficits in adult MIA offspring. Furthermore, whole-genome analysis suggests a strong interaction between Ikzf1 (IKAROS family zinc-finger 1) and neuronal differentiation. Intriguingly, VAC rescues excessive microglial Ikzf1 expression and attenuates microglial inflammatory responses in the MIA fetal brain. Our study implies that a preprocessed influenza vaccination prevents maternal bacterial infection from causing neocortical lamination impairments and autism-related behaviors in offspring.
- 13 August 2018
- Published by Springer Nature in Journal of Neuroinflammation
- Vol. 15 (1) , 1-17
Open AccessPrenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism
Prenatal infection is a substantial risk factor for neurodevelopmental disorders such as autism in offspring. We have previously reported that influenza vaccination (VAC) during early pregnancy contributes to neurogenesis and behavioral function in offspring. Here, we probe the efficacy of VAC pretreatment on autism-like behaviors in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) mouse model. We show that VAC improves abnormal fetal brain cytoarchitecture and lamination, an effect associated with promotion of intermediate progenitor cell differentiation in MIA fetal brain. These beneficial effects are sufficient to prevent social deficits in adult MIA offspring. Furthermore, whole-genome analysis suggests a strong interaction between Ikzf1 (IKAROS family zinc-finger 1) and neuronal differentiation. Intriguingly, VAC rescues excessive microglial Ikzf1 expression and attenuates microglial inflammatory responses in the MIA fetal brain. Our study implies that a preprocessed influenza vaccination prevents maternal bacterial infection from causing neocortical lamination impairments and autism-related behaviors in offspring.