Wenqi Jian
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Wenqi Jian has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Bo Yin
Institute of Sports Biology, Shaanxi Normal University, Xi’an, 710119, China
1 shared publication - Dean Ta
Fudan University
1 shared publication - Jianzhong Guo
Key Laboratory of Ultrasound of Shaanxi Province, School of Physics and Information Technology, Shaanxi Normal University, Xi’an, China
1 shared publication - Liang Tang
Institute of Sports Biology, Shaanxi Normal University, Xi’an 710119, China
1 shared publication - Lijun Sun
Institute of Sports Biology, Shaanxi Normal University, Xi'an, China
1 shared publication - Nan Li
Institute of Sports Biology, Shaanxi Normal University, Xi’an, 710119, China
1 shared publication
Latest Publications
- Open Access
- 22 December 2017
- Published by Springer Nature in Skeletal Muscle
- Vol. 7 (1) , 1-10
Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
Type 1 diabetes mellitus (T1DM) induces serious skeletal muscle atrophy. Low-intensity pulsed ultrasound (LIPUS) is a common treatment for skeletal muscle injury and is effective in accelerating the rate of muscle growth. However, to the best of our knowledge, whether LIPUS can improve skeletal muscle atrophy in type 1 diabetic rats has not been investigated. The rats were randomly divided into four groups: the normal control group (NC); the sham-treated diabetic control group (DC); the diabetic, insulin-treated group (DI) as a positive control; and the diabetic LIPUS therapy group (DL). The DL rats were treated with LIPUS (1 MHz, 30 mW/cm2) on the gastrocnemius for 20 min/day. After 6 weeks, the rats in the DC group showed severe muscle atrophy. However, LIPUS significantly improved type 1 diabetes-induced muscle atrophy, as evidenced by significantly enhanced muscle cross-sectional area, muscle mass, and strength. Moreover, compared with the DC group, LIPUS significantly activated Akt and upregulated the expression of mTOR, and LIPUS downregulated the expression of MSTN, its receptor ActRIIB, and FoxO1. These results indicate that LIPUS improved muscle atrophy induced by type 1 diabetes, and the MSTN/Akt/mTOR&FoxO1 signaling pathway may play a role in this improvement.
- 22 December 2017
- Published by Springer Nature in Skeletal Muscle
- Vol. 7 (1) , 1-10
Open AccessLow-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
Type 1 diabetes mellitus (T1DM) induces serious skeletal muscle atrophy. Low-intensity pulsed ultrasound (LIPUS) is a common treatment for skeletal muscle injury and is effective in accelerating the rate of muscle growth. However, to the best of our knowledge, whether LIPUS can improve skeletal muscle atrophy in type 1 diabetic rats has not been investigated. The rats were randomly divided into four groups: the normal control group (NC); the sham-treated diabetic control group (DC); the diabetic, insulin-treated group (DI) as a positive control; and the diabetic LIPUS therapy group (DL). The DL rats were treated with LIPUS (1 MHz, 30 mW/cm2) on the gastrocnemius for 20 min/day. After 6 weeks, the rats in the DC group showed severe muscle atrophy. However, LIPUS significantly improved type 1 diabetes-induced muscle atrophy, as evidenced by significantly enhanced muscle cross-sectional area, muscle mass, and strength. Moreover, compared with the DC group, LIPUS significantly activated Akt and upregulated the expression of mTOR, and LIPUS downregulated the expression of MSTN, its receptor ActRIIB, and FoxO1. These results indicate that LIPUS improved muscle atrophy induced by type 1 diabetes, and the MSTN/Akt/mTOR&FoxO1 signaling pathway may play a role in this improvement.