Olfat Gsib
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Olfat Gsib has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Christophe Egles
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
1 shared publication - Jean-Luc Duval
Laboratoire de BioMécanique et de BioIngénierie (BMBI) UMR CNRS 7388, Sorbonne Universités, Université de Technologie of Compiègne (UTC), 60200 Compiègne, France
1 shared publication - Marie Deneufchatel
Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules (Errmece), Institut des Matériaux, Université de Cergy-Pontoise, 95000 Cergy-Pontoise, France
1 shared publication - Mathieu Goczkowski
Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules (Errmece), Institut des Matériaux, Université de Cergy-Pontoise, 95000 Cergy-Pontoise, France
1 shared publication - Odile Fichet
CY Cergy Paris Université, LPPI
1 shared publication - Sidi A. Bencherif
University of Rouen Normandy
1 shared publication
Latest Publications
- Open Access
- 10 December 2017
- Published by MDPI AG in Nanomaterials
- Vol. 7 (12) , 436
Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering
Interpenetrating polymer networks (IPNs) have gained great attention for a number of biomedical applications due to their improved properties compared to individual components alone. In this study, we investigated the capacity of newly-developed naturally-derived IPNs as potential biomaterials for tissue engineering. These IPNs combine the biologic properties of a fibrous fibrin network polymerized at the nanoscale and the mechanical stability of polyethylene oxide (PEO). First, we assessed their cytotoxicity in vitro on L929 fibroblasts. We further evaluated their biocompatibility ex vivo with a chick embryo organotypic culture model. Subcutaneous implantations of the matrices were subsequently conducted on nude mice to investigate their biocompatibility in vivo. Our preliminary data highlighted that our biomaterials were non-cytotoxic (viability above 90%). The organotypic culture showed that the IPN matrices induced higher cell adhesion (across all the explanted organ tissues) and migration (skin, intestine) than the control groups, suggesting the advantages of using a biomimetic, yet mechanically-reinforced IPN-based matrix. We observed no major inflammatory response up to 12 weeks post implantation. All together, these data suggest that these fibrin-based IPNs are promising biomaterials for tissue engineering.
- 10 December 2017
- Published by MDPI AG in Nanomaterials
- Vol. 7 (12) , 436
Open AccessEvaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering
Interpenetrating polymer networks (IPNs) have gained great attention for a number of biomedical applications due to their improved properties compared to individual components alone. In this study, we investigated the capacity of newly-developed naturally-derived IPNs as potential biomaterials for tissue engineering. These IPNs combine the biologic properties of a fibrous fibrin network polymerized at the nanoscale and the mechanical stability of polyethylene oxide (PEO). First, we assessed their cytotoxicity in vitro on L929 fibroblasts. We further evaluated their biocompatibility ex vivo with a chick embryo organotypic culture model. Subcutaneous implantations of the matrices were subsequently conducted on nude mice to investigate their biocompatibility in vivo. Our preliminary data highlighted that our biomaterials were non-cytotoxic (viability above 90%). The organotypic culture showed that the IPN matrices induced higher cell adhesion (across all the explanted organ tissues) and migration (skin, intestine) than the control groups, suggesting the advantages of using a biomimetic, yet mechanically-reinforced IPN-based matrix. We observed no major inflammatory response up to 12 weeks post implantation. All together, these data suggest that these fibrin-based IPNs are promising biomaterials for tissue engineering.