Hanqiu Dong
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Hanqiu Dong has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Hongjie Liu
Department of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China
1 shared publication - Liang Chen
Department of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China
1 shared publication - Lingxiu Chen
Department of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China
1 shared publication - Min Ma
School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China
1 shared publication - Sha Zhan
Department of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China
1 shared publication - Yan Ma
Shandong University of Traditional Chinese Medicine, Jinan, 250355, China
1 shared publication
Latest Publications
- Open Access
- 16 November 2017
- Published by Springer Nature in BMC Complementary and Alternative Medicine
- Vol. 17 (1) , 491
Molecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium
Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear. In the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA). The chemical components of the VOAAF were searched in the database, and their target proteins were all identified in the PubChem, while drug-induced liver injury (DILI) genes were searched in the PubMed gene databases. The molecular network of protein targets for VOAAF and DILI genes was built with the IPA. The canonical pathways between the 2 networks were compared to decipher the molecular mechanisms of the liver injury induced by VOAAF. There were 159 target proteins for VOAAF and 338 genes related to DILI identified, which were further analyzed in the IPA. The canonical pathway comparison showed that VOAAF and DILI both worked on aryl hydrocarbon receptor (AHR), lipopolysaccharide (LPS)/interleukin 1 (IL-1) mediated inhibition of retinoid X receptor (RXR) function, pregnane X receptor (PXR)/RXR activation, xenobiotic metabolism, peroxisome proliferator-activated receptor (PPAR), hepatic cholestasis, farnesoid X receptor (FXR)/RXR activation, and glucocorticoid receptor. VOAAF-induced liver injury may be involved in many pathways in which the AHR signaling and LPS/IL-1 mediated inhibition of RXR function pathways could be the most vital.
- 16 November 2017
- Published by Springer Nature in BMC Complementary and Alternative Medicine
- Vol. 17 (1) , 491
Open AccessMolecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium
Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear. In the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA). The chemical components of the VOAAF were searched in the database, and their target proteins were all identified in the PubChem, while drug-induced liver injury (DILI) genes were searched in the PubMed gene databases. The molecular network of protein targets for VOAAF and DILI genes was built with the IPA. The canonical pathways between the 2 networks were compared to decipher the molecular mechanisms of the liver injury induced by VOAAF. There were 159 target proteins for VOAAF and 338 genes related to DILI identified, which were further analyzed in the IPA. The canonical pathway comparison showed that VOAAF and DILI both worked on aryl hydrocarbon receptor (AHR), lipopolysaccharide (LPS)/interleukin 1 (IL-1) mediated inhibition of retinoid X receptor (RXR) function, pregnane X receptor (PXR)/RXR activation, xenobiotic metabolism, peroxisome proliferator-activated receptor (PPAR), hepatic cholestasis, farnesoid X receptor (FXR)/RXR activation, and glucocorticoid receptor. VOAAF-induced liver injury may be involved in many pathways in which the AHR signaling and LPS/IL-1 mediated inhibition of RXR function pathways could be the most vital.