Danfeng Li
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Danfeng Li has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Jianghong Yuan
Department of Nephrology, People's Hospital of Tongchuan city, No. 12, Jiankang Street, Wangyi District, Tongchuan City, Shaanxi Province, 727000, People's Republic of China
1 shared publication - Jin-An Zhang
Department of Endocrinology and Rheumatology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital
1 shared publication - Liang-Feng Shi
Department of Endocrine Medicine, Jinshan Hospital, Fudan University, Shanghai, China
1 shared publication - Ling Xiao
Department of Psychiatry and Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, People's Republic of China
1 shared publication - Ni Yan
Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Shanghai, 201508, People's Republic of China
1 shared publication - Qiuming Yao
Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Shanghai, 201508, People's Republic of China
1 shared publication
Latest Publications
- Open Access
- 12 May 2017
- Published by Springer Nature in BMC Medical Genetics
- Vol. 18 (1) , 1-8
A case–control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population
Selenium is an essential trace and there is a high selenium concentration in the thyroid gland. Selenium deficiency may impair the thyroid function. The aim of this study was to investigate the association between three selenoprotein genes polymorphisms and autoimmune thyroid diseases. We genotyped six single-nucleotide polymorphisms (SNPs), rs6865453 in selenoprotein P gene (SELENOP), rs713041 rs2074451 rs3746165 in glutathione peroxidase 4 gene (GPX4) and rs28665122 and rs7178239 in selenoprotein S gene (SELENOS) by MassARRAY system using the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology in 1060 patients with autoimmune thyroid diseases and 938 healthy controls. Major alleles in rs6865453 of SELENOP, rs713041, rs2074451, rs3746165 of GPX4 decreased while the major allele C in rs28665122 of SELENOS increased in AITD patients than in the control. The allele C and genotype CC in rs7178239 of SELENOS showed different trend in GD and HT patients when compared with the control. All the distribution difference showed nonsignificant. Analysis according to clinical features including ophthalmopathy, hypothyroidism and family history came out to be negative either. Our findings suggest non-association between three selenoprotein genes and AITD, conflicting to the positive result in another population. Different selenium nutrition status in different populations may contribute to conflicting results, the contribution of genetic variants in AITD mechanism may be another reason.
- 12 May 2017
- Published by Springer Nature in BMC Medical Genetics
- Vol. 18 (1) , 1-8
Open AccessA case–control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population
Selenium is an essential trace and there is a high selenium concentration in the thyroid gland. Selenium deficiency may impair the thyroid function. The aim of this study was to investigate the association between three selenoprotein genes polymorphisms and autoimmune thyroid diseases. We genotyped six single-nucleotide polymorphisms (SNPs), rs6865453 in selenoprotein P gene (SELENOP), rs713041 rs2074451 rs3746165 in glutathione peroxidase 4 gene (GPX4) and rs28665122 and rs7178239 in selenoprotein S gene (SELENOS) by MassARRAY system using the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology in 1060 patients with autoimmune thyroid diseases and 938 healthy controls. Major alleles in rs6865453 of SELENOP, rs713041, rs2074451, rs3746165 of GPX4 decreased while the major allele C in rs28665122 of SELENOS increased in AITD patients than in the control. The allele C and genotype CC in rs7178239 of SELENOS showed different trend in GD and HT patients when compared with the control. All the distribution difference showed nonsignificant. Analysis according to clinical features including ophthalmopathy, hypothyroidism and family history came out to be negative either. Our findings suggest non-association between three selenoprotein genes and AITD, conflicting to the positive result in another population. Different selenium nutrition status in different populations may contribute to conflicting results, the contribution of genetic variants in AITD mechanism may be another reason.