Liangliang Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Liangliang Chen has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Jianjun Li
Department of Thyroid Surgery, Ningbo NO.2 Hospital, NO.41 Xibei Street, Ningbo City, 315000, Zhejiang Province, China
1 shared publication - Jueru Zheng
Department of Thyroid Surgery, Ningbo NO.2 Hospital, NO.41 Xibei Street, Ningbo City, 315000, Zhejiang Province, China
1 shared publication - Lei Dai
Department of Thyroid Surgery, Ningbo NO.2 Hospital, NO.41 Xibei Street, Ningbo City, 315000, Zhejiang Province, China
1 shared publication - Xianjiang Wu
Department of Thyroid Surgery, Ningbo No. 2 Hospital, Haishu, Ningbo, China
1 shared publication - Yaozong Wang
Department of Thyroid Surgery, Ningbo NO.2 Hospital, NO.41 Xibei Street, Ningbo City, 315000, Zhejiang Province, China
1 shared publication
Latest Publications
- Open Access
- 7 January 2017
- Published by Springer Nature in World Journal of Surgical Oncology
- Vol. 15 (1) , 1-6
MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer
Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear. The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis. A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95%CI 1.14–1.95, P = 0.007) by multiple Cox proportional hazard analysis. This study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.
- 7 January 2017
- Published by Springer Nature in World Journal of Surgical Oncology
- Vol. 15 (1) , 1-6
Open AccessMiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer
Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear. The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis. A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95%CI 1.14–1.95, P = 0.007) by multiple Cox proportional hazard analysis. This study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.