Ling Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Ling Chen has a total of 24 co-authors. Here are the top co-authors by number of shared publications:
- Bing Lang
Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China
2 shared publications - Jin-Bao Zhang
Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University
2 shared publications - Ning-Ning Song
Laboratory Animal Center, Fudan University, Shanghai, China
2 shared publications - Yu-Qiang Ding
Laboratory Animal Center, Fudan University, Shanghai, China
2 shared publications - Can-Can Shao
Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China
1 shared publication - Chan Zhang
Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China
1 shared publication
Latest Publications
- Open Access
- 13 December 2016
- Published by Springer Nature in Molecular Brain
- Vol. 9 (1) , 1-13
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.
- 13 December 2016
- Published by Springer Nature in Molecular Brain
- Vol. 9 (1) , 1-13
Open AccessOxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.
- Open Access
- 18 September 2014
- Published by Springer Nature in Molecular Brain
- Vol. 7 (1) , 68
A mouse line for inducible and reversible silencing of specific neurons
Genetic methods for inducibly and reversibly inhibiting neuronal activity of specific neurons are critical for exploring the functions of neuronal circuits. The engineered human glycine receptor, called ivermectin (IVM)-gated silencing receptor (IVMR), has been shown to possess this ability in vitro. Here we generated a mouse line, in which the IVMR coding sequence was inserted into the ROSA26 locus downstream of a loxP-flanked STOP cassette. Specific Cre-mediated IVMR expression was revealed by mis-expression of Cre in the striatum and by crossing with several Cre lines. Behavioral alteration was observed in Rosa26-IVMR mice with unilateral striatal Cre expression after systemic administration of IVM, and it could be re-initiated when IVM was applied again. A dramatic reduction in neuron firing was recorded in IVM-treated free moving Rosa26-IVMR;Emx1-Cre mice, and neuronal excitability was reduced within minutes as shown by recording in brain slice. This Rosa26-IVMR mouse line provides a powerful tool for exploring selective circuit functions in freely behaving mice.
- 18 September 2014
- Published by Springer Nature in Molecular Brain
- Vol. 7 (1) , 68
Open AccessA mouse line for inducible and reversible silencing of specific neurons
Genetic methods for inducibly and reversibly inhibiting neuronal activity of specific neurons are critical for exploring the functions of neuronal circuits. The engineered human glycine receptor, called ivermectin (IVM)-gated silencing receptor (IVMR), has been shown to possess this ability in vitro. Here we generated a mouse line, in which the IVMR coding sequence was inserted into the ROSA26 locus downstream of a loxP-flanked STOP cassette. Specific Cre-mediated IVMR expression was revealed by mis-expression of Cre in the striatum and by crossing with several Cre lines. Behavioral alteration was observed in Rosa26-IVMR mice with unilateral striatal Cre expression after systemic administration of IVM, and it could be re-initiated when IVM was applied again. A dramatic reduction in neuron firing was recorded in IVM-treated free moving Rosa26-IVMR;Emx1-Cre mice, and neuronal excitability was reduced within minutes as shown by recording in brain slice. This Rosa26-IVMR mouse line provides a powerful tool for exploring selective circuit functions in freely behaving mice.