Lei Zheng
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Lei Zheng has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Feng Zhang
Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Children’s Hospital, School of Medicine, University of Zhejiang, Hangzhou, Zhejiang 310013, China
1 shared publication - Haiyan Jin
Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Children’s Hospital, School of Medicine, University of Zhejiang, Hangzhou, Zhejiang 310013, China
1 shared publication - Lili Song
Department of Dermatology, Children’s Hospital, School of Medicine, University of Zhejiang, 57 Zhugan Lane, Yanan Road, Hangzhou, Zhejiang 310013, China
1 shared publication - Suhan Zhang
Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Children’s Hospital, School of Medicine, University of Zhejiang, Hangzhou, Zhejiang 310013, China
1 shared publication - Wei Li
Department of Dermatology, Children’s Hospital, School of Medicine, University of Zhejiang, 57 Zhugan Lane, Yanan Road, Hangzhou, Zhejiang 310013, China
1 shared publication - Xia Xu
Department of Dermatology, Children’s Hospital, School of Medicine, University of Zhejiang, 57 Zhugan Lane, Yanan Road, Hangzhou, Zhejiang 310013, China
1 shared publication
Latest Publications
- Open Access
- 16 September 2013
- Published by Springer Nature in Stem Cell Research & Therapy
- Vol. 4 (5) , 113
Mesenchymal stem cells modified with angiopoietin-1 gene promote wound healing
Introduction: Treatment of chronic skin wounds is difficult and largely ineffective. Little improvement has been shown in promoting the healing of these wounds in the past few decades. Innovative treatments to enhance chronic wound healing process are therefore needed. Methods: In this study, we examined the efficacy of angiopoietin-1 gene-modified bone marrow mesenchymal stem cells (Ang1-MSCs) on the promotion of cutaneous wound healing in rats. Excisional full-thickness wounds were treated with Ang1-MSCs, a recombinant adenovirus encoding angiopoietin-1 (Ad-Ang1), unmodified bone marrow mesenchymal stem cells (MSCs), or vehicle medium (sham). Results: The results showed that Ang1-MSCs significantly promoted wound healing with increased epidermal and dermal regeneration, and enhanced angiogenesis compared with MSCs, Ad-Ang1 or sham treatment. Moreover, Ang1-MSCs expressed CD31 in the wound, suggesting a direct contribution of Ang1-MSCs to angiogenesis. Conclusions: Here we show that Ang1-MSCs accelerate wound healing by promoting skin regeneration and angiogenesis, compared with MSCs or Ad-Ang1 alone.
- 16 September 2013
- Published by Springer Nature in Stem Cell Research & Therapy
- Vol. 4 (5) , 113
Open AccessMesenchymal stem cells modified with angiopoietin-1 gene promote wound healing
Introduction: Treatment of chronic skin wounds is difficult and largely ineffective. Little improvement has been shown in promoting the healing of these wounds in the past few decades. Innovative treatments to enhance chronic wound healing process are therefore needed. Methods: In this study, we examined the efficacy of angiopoietin-1 gene-modified bone marrow mesenchymal stem cells (Ang1-MSCs) on the promotion of cutaneous wound healing in rats. Excisional full-thickness wounds were treated with Ang1-MSCs, a recombinant adenovirus encoding angiopoietin-1 (Ad-Ang1), unmodified bone marrow mesenchymal stem cells (MSCs), or vehicle medium (sham). Results: The results showed that Ang1-MSCs significantly promoted wound healing with increased epidermal and dermal regeneration, and enhanced angiogenesis compared with MSCs, Ad-Ang1 or sham treatment. Moreover, Ang1-MSCs expressed CD31 in the wound, suggesting a direct contribution of Ang1-MSCs to angiogenesis. Conclusions: Here we show that Ang1-MSCs accelerate wound healing by promoting skin regeneration and angiogenesis, compared with MSCs or Ad-Ang1 alone.