Lei Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Lei Chen has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Cetewayo S. Rashid
Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA
1 shared publication - Ibolya Edit András
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33136-1019, USA
1 shared publication - Karyn A. Esser
Center for Muscle Biology, Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
1 shared publication - Melissa J Seelbach
Department of Neurosurgery, University of Kentucky, Lexington, KY, USA
1 shared publication - Michal Toborek
Institute of Physiotherapy and Health Sciences, Academy of Physical Education, 40-065 Katowice, Poland
1 shared publication - Minseon Park
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
1 shared publication
Latest Publications
- Open Access
- 1 January 2013
- Published by Springer Nature in Molecular Neurodegeneration
- Vol. 8 (1) , 22
Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood–brain barrier
There is no effective therapeutic intervention developed targeting cerebrovascular toxicity of drugs of abuse, including methamphetamine (METH). We hypothesize that exercise protects against METH-induced disruption of the blood–brain barrier (BBB) by enhancing the antioxidant capacity of cerebral microvessels and modulating caveolae-associated signaling. Mice were subjected to voluntary wheel running for 5 weeks resembling the voluntary pattern of human exercise, followed by injection with METH (10 mg/kg). The frequency, duration, and intensity of each running session were monitored for each mouse via a direct data link to a computer and the running data are analyzed by Clock lab™ Analysis software. Controls included mice sedentary that did not have access to running wheels and/or injections with saline.
- 1 January 2013
- Published by Springer Nature in Molecular Neurodegeneration
- Vol. 8 (1) , 22
Open AccessVoluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood–brain barrier
There is no effective therapeutic intervention developed targeting cerebrovascular toxicity of drugs of abuse, including methamphetamine (METH). We hypothesize that exercise protects against METH-induced disruption of the blood–brain barrier (BBB) by enhancing the antioxidant capacity of cerebral microvessels and modulating caveolae-associated signaling. Mice were subjected to voluntary wheel running for 5 weeks resembling the voluntary pattern of human exercise, followed by injection with METH (10 mg/kg). The frequency, duration, and intensity of each running session were monitored for each mouse via a direct data link to a computer and the running data are analyzed by Clock lab™ Analysis software. Controls included mice sedentary that did not have access to running wheels and/or injections with saline.