Kelly Soady
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Kelly Soady has a total of 1 co-authors. Here are the top co-authors by number of shared publications:
- Matthew John Smalley
The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK
1 shared publication
Latest Publications
- Open Access
- 10 September 2012
- Published by Springer Nature in Breast Cancer Research
- Vol. 14 (5) , 319
Slugging their way to immortality: driving mammary epithelial cells into a stem cell-like state
Delineating the molecular factors that define and maintain the mammary stem cell state is vital for understanding normal development and tumourigenesis. A recent study by Guo and colleagues identifies two master transcriptional regulators of mammary stem cells, Slug and Sox9, ectopic expression of which confers stem cell attributes on differentiated mammary epithelial cells. Slug and Sox9 expression was also shown to determine in vivo metastatic potential of human breast cancer cell lines. Understanding these factors in the context of normal lineage differentiation is an important step toward elucidating the mammary epithelial cell hierarchy and the origins of cancer stem cells.
- 10 September 2012
- Published by Springer Nature in Breast Cancer Research
- Vol. 14 (5) , 319
Open AccessSlugging their way to immortality: driving mammary epithelial cells into a stem cell-like state
Delineating the molecular factors that define and maintain the mammary stem cell state is vital for understanding normal development and tumourigenesis. A recent study by Guo and colleagues identifies two master transcriptional regulators of mammary stem cells, Slug and Sox9, ectopic expression of which confers stem cell attributes on differentiated mammary epithelial cells. Slug and Sox9 expression was also shown to determine in vivo metastatic potential of human breast cancer cell lines. Understanding these factors in the context of normal lineage differentiation is an important step toward elucidating the mammary epithelial cell hierarchy and the origins of cancer stem cells.