Santanu Basu
Research Subjects
Research Interests
Santanu Basu has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Apurba K Bandyopadhyay
Molecular and Human Genetics Division, CSIR- Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata, 700 032, India
1 shared publication - Ashok Kumar Giri
Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India
1 shared publication - Debmita Chatterjee
Molecular and Human Genetics Division, CSIR- Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata, 700 032, India
1 shared publication - J. Christopher States
Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA
1 shared publication - Nandana Das
Molecular and Human Genetics Division, CSIR- Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata, 700 032, India
1 shared publication - Niladri Shekhar Majumder
Roche Diagnostics India Pvt. Ltd
1 shared publication
Latest Publications
- Open Access
- 10 August 2012
- Published by Springer Nature in BMC Public Health
- Vol. 12 (1) , 639
Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India
Background: Arsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India. Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.Methods: Effect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.Results: Our results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased in the arsenic exposed group.Conclusions: Chronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and imparts increased cardiovascular risk.
- 10 August 2012
- Published by Springer Nature in BMC Public Health
- Vol. 12 (1) , 639
Open AccessArsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India
Background: Arsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India. Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.Methods: Effect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.Results: Our results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased in the arsenic exposed group.Conclusions: Chronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and imparts increased cardiovascular risk.