Lucas González-Herrera
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Lucas González-Herrera has a total of 43 co-authors. Here are the top co-authors by number of shared publications:
- Jesús Ayuso
Department of Physical Chemistry, Faculty of Sciences, INBIO, University of Cadiz, 11510 Puerto Real, Spain
5 shared publications - Domingo Villero-Carro
Dean Official College of Industrial Technical Experts and Engineers of Cadiz, 11010 Cadiz, Spain
4 shared publications - Jose Antonio Lorente
Laboratory of Genetic Identification & Human Rights (LABIGEN-UGR), Department of Legal Medicine, Faculty of Medicine, University of Granada, PTS Granada, Av. Investigación 11, 18016 Granada, Spain
4 shared publications - José Ángel Álvarez
Department of Physical Chemistry, Faculty of Sciences, INBIO, University of Cadiz, 11510 Puerto Real, Spain
4 shared publications Aurora Valenzuela
Department of Forensic Medicine, Faculty of Medicine, University of Granada, Avenida de la Investigación 11, 18016 Granada, Spain
3 shared publications- Jose Carlos Vera-Jimenez
Coordinator of Studies Public Safety School of the Cádiz City Council, 11010 Cadiz, Spain
3 shared publications
Latest Publications
- Open Access
- 1 July 2025
- Published by Wolters Kluwer Health in Indian Journal of Occupational and Environmental Medicine
- Vol. 29 (3) , 188-192
Police Ergonomic Parameters as a Method to Evaluate the Training at Cadiz Public Security School on the Use of Police Force of Candidates to Become Local Police Officers in Andalucía
Background: Because of the numerous debates about the training on the use of force provided to police officers, this study intends to evaluate several parameters (police ergonomic parameters, PEP) in connection with such training. Research Method: A smartsuit equipped with a set of 19 wireless sensors, including triaxial accelerometers, inertial measurement units, gyroscopes, and geomagnetic sensors, was used. Biomechanics of Body software application was used to evaluate the risks associated with the basic technique number 1 of the operational-tactical procedures (OTP) with regard to the established parameters (PEP). The OTP basic technique number 1 was performed by four novice police officers. Results: According to the evaluation of a number of specific parameters such as rapid entire body assessment, asymmetry over the sagittal plane, compression force at the L5-S1 junction, and shear force at the L5-S1 junction, it was observed that the measured values clearly varied depending on each individual’s performance, although they remained consistent with the values established by PEP and were significantly different from the values measured when a police officer used a traditional physical intervention procedure, in which case, the values measured were indicative of higher risks. Conclusions: To achieve lower and more uniform values in terms of risk, we believe that it is necessary to employ a greater number of hours for the training of police officers on the use of force and also the convenience of conducting further studies on a larger and more representative sample of officers.
- 1 July 2025
- Published by Wolters Kluwer Health in Indian Journal of Occupational and Environmental Medicine
- Vol. 29 (3) , 188-192
Open AccessPolice Ergonomic Parameters as a Method to Evaluate the Training at Cadiz Public Security School on the Use of Police Force of Candidates to Become Local Police Officers in Andalucía
Background: Because of the numerous debates about the training on the use of force provided to police officers, this study intends to evaluate several parameters (police ergonomic parameters, PEP) in connection with such training. Research Method: A smartsuit equipped with a set of 19 wireless sensors, including triaxial accelerometers, inertial measurement units, gyroscopes, and geomagnetic sensors, was used. Biomechanics of Body software application was used to evaluate the risks associated with the basic technique number 1 of the operational-tactical procedures (OTP) with regard to the established parameters (PEP). The OTP basic technique number 1 was performed by four novice police officers. Results: According to the evaluation of a number of specific parameters such as rapid entire body assessment, asymmetry over the sagittal plane, compression force at the L5-S1 junction, and shear force at the L5-S1 junction, it was observed that the measured values clearly varied depending on each individual’s performance, although they remained consistent with the values established by PEP and were significantly different from the values measured when a police officer used a traditional physical intervention procedure, in which case, the values measured were indicative of higher risks. Conclusions: To achieve lower and more uniform values in terms of risk, we believe that it is necessary to employ a greater number of hours for the training of police officers on the use of force and also the convenience of conducting further studies on a larger and more representative sample of officers.
- Open Access
- 20 January 2025
- Published by Oxford University Press (OUP) in Carcinogenesis
- Vol. 46 (1)
Copper in colorectal cancer patients: a systematic review and meta-analysis
Several clinical studies have evaluated the relationship between copper on colorectal cancer (CRC), but the results are contradictory. This study aimed to conduct a systematic review and meta-analysis to investigate copper measured in two biological matrices (serum/plasma/blood and tissue) and dietary intake in CRC patients compared to healthy controls. We conducted a comprehensive and systematic search in PubMed, Scopus, Embase, and Web of Science. We included studies that reported copper levels in serum/plasma/blood, tissue, or from the diet, with an observational study design (cohort and case–control studies). Study quality was assessed with the Newcastle–Ottawa scale and potential causes of heterogeneity were evaluated. Standardized mean differences (SMD) with 95% confidence interval (CI) were pooled using random-effect models. Overall pooled odds ratio and 95% CI for the risk of CRC were calculated. Twenty-six studies (23 case–control and 3 cohort studies) with a total of 227 354 participants were included. Most of the studies presented low (50%) or moderate quality (42.3%). No differences in serum/plasma/blood copper levels (SMD = 0.23; 95% CI: −0.23, 0.70; I2 = 97.3%, 19 studies), tissue copper levels (SMD = −1.69; 95% CI: −3.41, 0.03; I2 = 85.6%, 2 studies), or copper/zinc ratio (SMD = 1.19; 95% CI: 0.54, 1.84; I2 = 95.3%, 6 studies) were found between CRC patients and healthy controls. Regarding dietary copper, CRC patients had a lower intake (SMD = −0.27; 95% CI: −0.51, −0.03; I2 = 0.0%, 2 studies). No differences were found in copper levels between CRC patients and healthy controls. However, evidence shows mostly low or moderate quality, and results were heterogeneous. More prospective studies with an adequate methodological approach are needed.
- 20 January 2025
- Published by Oxford University Press (OUP) in Carcinogenesis
- Vol. 46 (1)
Open AccessCopper in colorectal cancer patients: a systematic review and meta-analysis
Several clinical studies have evaluated the relationship between copper on colorectal cancer (CRC), but the results are contradictory. This study aimed to conduct a systematic review and meta-analysis to investigate copper measured in two biological matrices (serum/plasma/blood and tissue) and dietary intake in CRC patients compared to healthy controls. We conducted a comprehensive and systematic search in PubMed, Scopus, Embase, and Web of Science. We included studies that reported copper levels in serum/plasma/blood, tissue, or from the diet, with an observational study design (cohort and case–control studies). Study quality was assessed with the Newcastle–Ottawa scale and potential causes of heterogeneity were evaluated. Standardized mean differences (SMD) with 95% confidence interval (CI) were pooled using random-effect models. Overall pooled odds ratio and 95% CI for the risk of CRC were calculated. Twenty-six studies (23 case–control and 3 cohort studies) with a total of 227 354 participants were included. Most of the studies presented low (50%) or moderate quality (42.3%). No differences in serum/plasma/blood copper levels (SMD = 0.23; 95% CI: −0.23, 0.70; I2 = 97.3%, 19 studies), tissue copper levels (SMD = −1.69; 95% CI: −3.41, 0.03; I2 = 85.6%, 2 studies), or copper/zinc ratio (SMD = 1.19; 95% CI: 0.54, 1.84; I2 = 95.3%, 6 studies) were found between CRC patients and healthy controls. Regarding dietary copper, CRC patients had a lower intake (SMD = −0.27; 95% CI: −0.51, −0.03; I2 = 0.0%, 2 studies). No differences were found in copper levels between CRC patients and healthy controls. However, evidence shows mostly low or moderate quality, and results were heterogeneous. More prospective studies with an adequate methodological approach are needed.
- Open Access
- 18 January 2024
- Published by MDPI AG in Preprints.org
Ergonomic Evaluation of the Use of force in the training of the Local Police of Cádiz (Spain) by REBA and Marras
(1) Background: This text emphasizes concerns regarding the safety of Spanish police officers at-tributed to inadequate training, employing biomechanics for the analysis and mitigation of risks during Use of Force training. The elevated global prevalence of musculoskeletal disorders under-scores the imperative for effective occupational health measures. The study concentrates on evalu-ating injury risks in novice police officers during Use of Force training. (2) Research method: The movements of police officers were captured using a Rokoko Smartsuit Pro equipped with 19 sen-sors. The Biomechanics of Bodies software processed the data, providing REBA and Marras risk scores. Statistical tests were conducted, and Operational Tactical Procedures (OTP) were inte-grated into police training. A diverse group of officers participated, categorized by training level and equipped with the Rokoko Smartsuit. (3) Results: The study evaluates police force training us-ing REBA and Marras methods. REBA scores indicate a moderate to high injury risk, suggesting effective technique design. ANOVA reveals no significant differences between training levels. Marras analysis, characterized by non-normal distribution, unveils varied risk perceptions among groups via the Kruskal-Wallis test. (4) Conclusions: The analysis of both the REBA and Marras methods implies the effectiveness of the OTP technique in reducing injury risks across dif-ferent training levels. The ANOVA test indicates no significant differences in REBA Maximum Scores between the groups. However, the Kruskal-Wallis test for Marras Probability of high-risk values suggests distinctions in medians between training levels. The combined analysis visually illustrates variations in membership regions between expert, intermediate, and novice groups.
- 18 January 2024
- Published by MDPI AG in Preprints.org
Open AccessErgonomic Evaluation of the Use of force in the training of the Local Police of Cádiz (Spain) by REBA and Marras
(1) Background: This text emphasizes concerns regarding the safety of Spanish police officers at-tributed to inadequate training, employing biomechanics for the analysis and mitigation of risks during Use of Force training. The elevated global prevalence of musculoskeletal disorders under-scores the imperative for effective occupational health measures. The study concentrates on evalu-ating injury risks in novice police officers during Use of Force training. (2) Research method: The movements of police officers were captured using a Rokoko Smartsuit Pro equipped with 19 sen-sors. The Biomechanics of Bodies software processed the data, providing REBA and Marras risk scores. Statistical tests were conducted, and Operational Tactical Procedures (OTP) were inte-grated into police training. A diverse group of officers participated, categorized by training level and equipped with the Rokoko Smartsuit. (3) Results: The study evaluates police force training us-ing REBA and Marras methods. REBA scores indicate a moderate to high injury risk, suggesting effective technique design. ANOVA reveals no significant differences between training levels. Marras analysis, characterized by non-normal distribution, unveils varied risk perceptions among groups via the Kruskal-Wallis test. (4) Conclusions: The analysis of both the REBA and Marras methods implies the effectiveness of the OTP technique in reducing injury risks across dif-ferent training levels. The ANOVA test indicates no significant differences in REBA Maximum Scores between the groups. However, the Kruskal-Wallis test for Marras Probability of high-risk values suggests distinctions in medians between training levels. The combined analysis visually illustrates variations in membership regions between expert, intermediate, and novice groups.
- Open Access
- 30 October 2023
- Published by MDPI AG in Preprints.org
Police Ergonomic Parameters as a Method to Evaluate the Training at Cadiz Public Security School on the Use of Police Force of Candidates to Become Local Police Officers in Andalucía.
(1) Background:. Because of the numerous debates about the training on the use of force provided to police officers, this study intends to evaluate several parameters (Police Ergonomic Parameters, PEP) in connection with such training. (2) Research method: : A smartsuit equipped with a set of 19 wireless sensors including triaxial accelerometers, Inertial Measurement Units (IMU), gyroscopes and geomagnetic sensors has been used. Biomechanics of Body (BoB) software application allowed to evaluate the risks associated to the basic technique number 1 of the Operational Tactical Procedures (OTP) with regard to the established parameters (PEP). The OTP basic technique number 1 was performed by 4 novice police officers. (3) Results: According to the evaluation of a number of specific parameters such as Rapid Entire Body Assessment (REBA), asymmetry over the sagittal plane, compression force at the L5-pelvic junction, shear force at the L5-pelvic junction and total muscle power, it was observed that the measured values clearly varied depending on each individual's performance, although they remained consistent with the values established by Police Ergonomic Parameters, and were significantly different from the values measured when a police officer used a traditional physical intervention procedure, in which case, the values measured were indicative of higher risks. (4) Conclusions: In order to achieve lower and more uniform values in terms of risk, we believe that it is necessary to employ a greater number of hours to the training of police officers on the use of force and also the convenience of conducting further studies on a larger and more representative sample of officers.
- 30 October 2023
- Published by MDPI AG in Preprints.org
Open AccessPolice Ergonomic Parameters as a Method to Evaluate the Training at Cadiz Public Security School on the Use of Police Force of Candidates to Become Local Police Officers in Andalucía.
(1) Background:. Because of the numerous debates about the training on the use of force provided to police officers, this study intends to evaluate several parameters (Police Ergonomic Parameters, PEP) in connection with such training. (2) Research method: : A smartsuit equipped with a set of 19 wireless sensors including triaxial accelerometers, Inertial Measurement Units (IMU), gyroscopes and geomagnetic sensors has been used. Biomechanics of Body (BoB) software application allowed to evaluate the risks associated to the basic technique number 1 of the Operational Tactical Procedures (OTP) with regard to the established parameters (PEP). The OTP basic technique number 1 was performed by 4 novice police officers. (3) Results: According to the evaluation of a number of specific parameters such as Rapid Entire Body Assessment (REBA), asymmetry over the sagittal plane, compression force at the L5-pelvic junction, shear force at the L5-pelvic junction and total muscle power, it was observed that the measured values clearly varied depending on each individual's performance, although they remained consistent with the values established by Police Ergonomic Parameters, and were significantly different from the values measured when a police officer used a traditional physical intervention procedure, in which case, the values measured were indicative of higher risks. (4) Conclusions: In order to achieve lower and more uniform values in terms of risk, we believe that it is necessary to employ a greater number of hours to the training of police officers on the use of force and also the convenience of conducting further studies on a larger and more representative sample of officers.
- Open Access
A Multidisciplinary Vision of the Criminal, Social and Occupational Risk Consequences of the Use of Police Force
(1) Background: The use of force by public and private security forces is currently an issue of great relevance because of the potential injuries caused by any excessive use of force by either active or passive subjects or a deficit in the real mastery of appropriate physical intervention techniques (PITs). For this reason, certain traditionally used physical intervention techniques have been questioned by scientific research studies and punished by justice. On the other hand, certain media have dealt with this matter in a biased and unfair manner by broadcasting videos where the use of force by police officer is displayed out of context. As a consequence, this problem has been brought under the spotlight, causing general uneasiness of the communities and rapidly spreading over social networks while favoring all sorts of parallel judgments. (2) Research method: A suit was equipped with 19 inertial measurement units (IMUs) and a Biomechanics of Bodies software application for Marras analysis of the data collected on trajectory, trunk twisting velocity, sagittal angle, load, and nature and severity of the injuries associated with the different intervention techniques examined. (3) Results: According to the data registered, the implementation of operational tactical procedures (OTPs) reduces the probability of injuries and leads to a more satisfactory outcome. (4) Conclusions: The implementation of operational tactical procedures, together with an awareness of the risks associated with the excessive use of force by public and private security forces and bodies, could reduce the risk of injuries suffered by both officers and citizens.
Open AccessA Multidisciplinary Vision of the Criminal, Social and Occupational Risk Consequences of the Use of Police Force
(1) Background: The use of force by public and private security forces is currently an issue of great relevance because of the potential injuries caused by any excessive use of force by either active or passive subjects or a deficit in the real mastery of appropriate physical intervention techniques (PITs). For this reason, certain traditionally used physical intervention techniques have been questioned by scientific research studies and punished by justice. On the other hand, certain media have dealt with this matter in a biased and unfair manner by broadcasting videos where the use of force by police officer is displayed out of context. As a consequence, this problem has been brought under the spotlight, causing general uneasiness of the communities and rapidly spreading over social networks while favoring all sorts of parallel judgments. (2) Research method: A suit was equipped with 19 inertial measurement units (IMUs) and a Biomechanics of Bodies software application for Marras analysis of the data collected on trajectory, trunk twisting velocity, sagittal angle, load, and nature and severity of the injuries associated with the different intervention techniques examined. (3) Results: According to the data registered, the implementation of operational tactical procedures (OTPs) reduces the probability of injuries and leads to a more satisfactory outcome. (4) Conclusions: The implementation of operational tactical procedures, together with an awareness of the risks associated with the excessive use of force by public and private security forces and bodies, could reduce the risk of injuries suffered by both officers and citizens.
- Open Access
- 23 April 2023
- Published by MDPI AG in Preprints.org
A Multidisciplinary Vision of the Criminal, Social and Occupational Risk Consequences of the Use of Police Force
(1) Background: the use of force by Public and Private Security Forces is currently an issue of great relevance because of the potential injuries that any excessive use of force by either the active or passive subjects or a deficit in the real mastery of the appropriate Physical Intervention Techniques (PIT) may cause. For this reason, certain traditionally used Physical Intervention Techniques have been questioned by scientific research studies and punished by justice. On the other hand, certain media have dealt with this matter in a biased and unfair manner by broadcasting videos where the use of force by police officer is displayed out of context. As a consequence, this problem has been brought under the spotlight, causing general uneasiness of the communities and rapidly spreading over social networks while favoring all sorts of parallel judgments. (2) Research method: A suit equipped with 19 Inertial Measurement Units (IMU) and a Biomechanics of Bodies software application for the Marras’ analysis of the data collected on trajectory, trunk twisting velocity, its sagittal angle, load, nature and severity of the injuries associated to the different intervention techniques that have been examined. (3) Results: according to the data registered, the implementation of Operational Tactical Procedures (OTP) reduces the probability of injuries and leads to a more satisfactory outcome. (4) Conclusions: the implementation of Operational Tactical Procedures, to-gether with the awareness on the risks associated to the excessive use of force by Public and Private Security Forces and Bodies, could reduce the risk of injuries suffered by both officers and citizens.
- 23 April 2023
- Published by MDPI AG in Preprints.org
Open AccessA Multidisciplinary Vision of the Criminal, Social and Occupational Risk Consequences of the Use of Police Force
(1) Background: the use of force by Public and Private Security Forces is currently an issue of great relevance because of the potential injuries that any excessive use of force by either the active or passive subjects or a deficit in the real mastery of the appropriate Physical Intervention Techniques (PIT) may cause. For this reason, certain traditionally used Physical Intervention Techniques have been questioned by scientific research studies and punished by justice. On the other hand, certain media have dealt with this matter in a biased and unfair manner by broadcasting videos where the use of force by police officer is displayed out of context. As a consequence, this problem has been brought under the spotlight, causing general uneasiness of the communities and rapidly spreading over social networks while favoring all sorts of parallel judgments. (2) Research method: A suit equipped with 19 Inertial Measurement Units (IMU) and a Biomechanics of Bodies software application for the Marras’ analysis of the data collected on trajectory, trunk twisting velocity, its sagittal angle, load, nature and severity of the injuries associated to the different intervention techniques that have been examined. (3) Results: according to the data registered, the implementation of Operational Tactical Procedures (OTP) reduces the probability of injuries and leads to a more satisfactory outcome. (4) Conclusions: the implementation of Operational Tactical Procedures, to-gether with the awareness on the risks associated to the excessive use of force by Public and Private Security Forces and Bodies, could reduce the risk of injuries suffered by both officers and citizens.
- Open Access
- 19 April 2020
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 17 (8) , 2809
A Legal and Forensic Medicine Approach to Police Physical Intervention Techniques in High-Risk Situations
Background: The physical intervention techniques (PITs) typically used by the police in troublesome situations are examined in terms of injuring potential depending on whether they target a body zone of high, medium or low vulnerability. Based on legal and forensic considerations, and principles of congruence, opportunity and proportionality, a need exists to favor opponent locking and arrest techniques targeting non-vulnerable zones to minimize the risk of severe damage. Methods: A search of the training manuals for the different kind of law of enforcement officers was carried out. Revision of injuries was available from electronic databases of academic o medical journals. Results: Three different locking and arrest PITs based on operational tactical procedures (OTP) that avoid zones of high or medium vulnerability are proposed. The new techniques use blocking, diverting and grabbing of the upper and lower limbs, followed by dislocation and locking of the same targets. Conclusions: The damaging potential of such PITs was assessed in terms of anatomical region and most were found to have a high risk of severe damage. The alternative PITs proposed here, which rely on OTP, improve in legal and forensic medical terms on existing choices and dramatically reduce the risk of injuring arrestees.
- 19 April 2020
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 17 (8) , 2809
Open AccessA Legal and Forensic Medicine Approach to Police Physical Intervention Techniques in High-Risk Situations
Background: The physical intervention techniques (PITs) typically used by the police in troublesome situations are examined in terms of injuring potential depending on whether they target a body zone of high, medium or low vulnerability. Based on legal and forensic considerations, and principles of congruence, opportunity and proportionality, a need exists to favor opponent locking and arrest techniques targeting non-vulnerable zones to minimize the risk of severe damage. Methods: A search of the training manuals for the different kind of law of enforcement officers was carried out. Revision of injuries was available from electronic databases of academic o medical journals. Results: Three different locking and arrest PITs based on operational tactical procedures (OTP) that avoid zones of high or medium vulnerability are proposed. The new techniques use blocking, diverting and grabbing of the upper and lower limbs, followed by dislocation and locking of the same targets. Conclusions: The damaging potential of such PITs was assessed in terms of anatomical region and most were found to have a high risk of severe damage. The alternative PITs proposed here, which rely on OTP, improve in legal and forensic medical terms on existing choices and dramatically reduce the risk of injuring arrestees.
- 1 September 2019
- Published by Elsevier in Forensic Science International
- Vol. 302, 109876
mRNA expression patterns in human myocardial tissue, pericardial fluid and blood, and its contribution to the diagnosis of cause of death
- 1 September 2019
- Published by Elsevier in Forensic Science International
- Vol. 302, 109876
mRNA expression patterns in human myocardial tissue, pericardial fluid and blood, and its contribution to the diagnosis of cause of death
- 8 March 2016
- Published by Springer Nature in Forensic Science, Medicine and Pathology
- Vol. 12 (2) , 181-188
Cardiac troponin T determination by a highly sensitive assay in postmortem serum and pericardial fluid
Purpose The main objective of this study was to test, for the first time, a highly sensitive cardiac troponin T (cTnThs) assay in postmortem serum and pericardial fluid and to evaluate cardiac troponin T (cTnT) levels and their stability after death at different postmortem intervals, in an attempt to determine the viability of the cTnThs assay in the postmortem diagnosis of the cause of death. Methods cTnT levels were determined in serum and pericardial fluid samples taken from 58 cadavers at known postmortem intervals, whose causes of death were categorized into the following groups: (1) sudden cardiac deaths, (2) multiple trauma, (3) mechanical asphyxia, and (4) other natural deaths. cTnT was determined by inmunoassay, using the Troponin T highly sensitive STAT assay (Roche®). Results Average cTnT levels measured by a highly sensitive assay in postmortem serum were markedly higher than clinical serum levels. Moreover, similar results, higher cTnT levels in postmortem pericardial fluid, were obtained when compared to levels found in pericardial fluid taken from two living patients during coronary artery bypass surgery. cTnT levels in both postmortem fluids remained stable for up to 34 h after death. No differences in cTnT levels in either postmortem fluid by sex and age were detected. Levels of cTnT found in pericardial fluid in the other natural deaths group were significantly lower than the cTnT levels found in that postmortem fluid from any of the other causes of death groups. Conclusion It is therefore reasonable to conclude that determination of cTnT by a highly sensitive assay in pericardial fluid can provide forensic pathologists with a complementary test to the diagnosis of cause of death.
- 8 March 2016
- Published by Springer Nature in Forensic Science, Medicine and Pathology
- Vol. 12 (2) , 181-188
Cardiac troponin T determination by a highly sensitive assay in postmortem serum and pericardial fluid
Purpose The main objective of this study was to test, for the first time, a highly sensitive cardiac troponin T (cTnThs) assay in postmortem serum and pericardial fluid and to evaluate cardiac troponin T (cTnT) levels and their stability after death at different postmortem intervals, in an attempt to determine the viability of the cTnThs assay in the postmortem diagnosis of the cause of death. Methods cTnT levels were determined in serum and pericardial fluid samples taken from 58 cadavers at known postmortem intervals, whose causes of death were categorized into the following groups: (1) sudden cardiac deaths, (2) multiple trauma, (3) mechanical asphyxia, and (4) other natural deaths. cTnT was determined by inmunoassay, using the Troponin T highly sensitive STAT assay (Roche®). Results Average cTnT levels measured by a highly sensitive assay in postmortem serum were markedly higher than clinical serum levels. Moreover, similar results, higher cTnT levels in postmortem pericardial fluid, were obtained when compared to levels found in pericardial fluid taken from two living patients during coronary artery bypass surgery. cTnT levels in both postmortem fluids remained stable for up to 34 h after death. No differences in cTnT levels in either postmortem fluid by sex and age were detected. Levels of cTnT found in pericardial fluid in the other natural deaths group were significantly lower than the cTnT levels found in that postmortem fluid from any of the other causes of death groups. Conclusion It is therefore reasonable to conclude that determination of cTnT by a highly sensitive assay in pericardial fluid can provide forensic pathologists with a complementary test to the diagnosis of cause of death.
- 1 October 2013
- Published by Elsevier in Forensic Science International
- Vol. 232 (1-3) , 218-228
Studies on RNA integrity and gene expression in human myocardial tissue, pericardial fluid and blood, and its postmortem stability
- 1 October 2013
- Published by Elsevier in Forensic Science International
- Vol. 232 (1-3) , 218-228
Studies on RNA integrity and gene expression in human myocardial tissue, pericardial fluid and blood, and its postmortem stability