Agustina Legaz-García
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Agustina Legaz-García has a total of 38 co-authors. Here are the top co-authors by number of shared publications:
- Agustín Ruiz
Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX
1 shared publication - Alejandro Romo-Astorga
Department of Structural Genomics, Neocodex, Avda. Charles Darwin, Sevilla, s/n 41092, Spain
1 shared publication Alzheimer'S Disease Neuroimaging Initiative
Department of Structural Genomics Avda. Charles Darwin, Sevilla 41092 Neocodex s/n Spain
1 shared publication- Ana Espinosa
Ace Alzheimer Center Barcelona, Universitat Internacional De Catalunya, Barcelona, Spain
1 shared publication - Ana Mauleón
Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Calle del Marqués de Sentmenat, Barcelona, 35-3708029, Spain
1 shared publication - Antonio González-Pérez
Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain
1 shared publication
Latest Publications
- Open Access
- 31 May 2011
- Published by Springer Nature in Genome Medicine
- Vol. 3 (5) , 33
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
Background: In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population. Methods: We genotyped 1,128 individuals using the Affymetrix Nsp I 250K chip. A sample of 327 sporadic AD patients and 801 controls with unknown cognitive status from the Spanish general population were included in our initial study. To increase the power of the study, we combined our results with those of four other public GWAS datasets by applying identical quality control filters and the same imputation methods, which were then analyzed with a global meta-GWAS. A replication sample with 2,200 sporadic AD patients and 2,301 controls was genotyped to confirm our GWAS findings. Results: Meta-analysis of our data and independent replication datasets allowed us to confirm a novel genome-wide significant association of AD with the membrane-spanning 4-domains subfamily A (MS4A) gene cluster (rs1562990, P = 4.40E-11, odds ratio = 0.88, 95% confidence interval 0.85 to 0.91, n = 10,181 cases and 14,341 controls). Conclusions: Our results underscore the importance of international efforts combining GWAS datasets to isolate genetic loci for complex diseases.
- 31 May 2011
- Published by Springer Nature in Genome Medicine
- Vol. 3 (5) , 33
Open AccessThe membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
Background: In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population. Methods: We genotyped 1,128 individuals using the Affymetrix Nsp I 250K chip. A sample of 327 sporadic AD patients and 801 controls with unknown cognitive status from the Spanish general population were included in our initial study. To increase the power of the study, we combined our results with those of four other public GWAS datasets by applying identical quality control filters and the same imputation methods, which were then analyzed with a global meta-GWAS. A replication sample with 2,200 sporadic AD patients and 2,301 controls was genotyped to confirm our GWAS findings. Results: Meta-analysis of our data and independent replication datasets allowed us to confirm a novel genome-wide significant association of AD with the membrane-spanning 4-domains subfamily A (MS4A) gene cluster (rs1562990, P = 4.40E-11, odds ratio = 0.88, 95% confidence interval 0.85 to 0.91, n = 10,181 cases and 14,341 controls). Conclusions: Our results underscore the importance of international efforts combining GWAS datasets to isolate genetic loci for complex diseases.