Satheesha Babu Bk

Teachers’ Day: Celebrating Integrity in Leadership, None | RGUHS Journal of Pharmaceutical Sciences | Journalgrid

Accreditations in Pharmacy Education: Striving for Quality or Creating Redundancy?, None | RGUHS Journal of Pharmaceutical Sciences | Journalgrid

A Tribute to Professor H.L. Bhalla: A Legacy of Excellence in Pharmaceutical Education and Research, None | RGUHS Journal of Pharmaceutical Sciences | Journalgrid

The Importance of Research in Academic Institutions: A Reflection on Our University’s Commitment, None | RGUHS Journal of Pharmaceutical Sciences | Journalgrid

Celebrating the Legacy of Mahadev Lal Shroff: A Pioneer in Indian Pharmaceutical Education, None | RGUHS Journal of Pharmaceutical Sciences | Journalgrid

Navigating Uncharted Waters: A Vision for our Pharmacy Journal, None | RGUHS Journal of Pharmaceutical Sciences | Journalgrid

Parkinson Disease (PD) is a chronic disorder of central nervous system mainly affecting the motor systems. The drug of choice to treat PD is Rasagiline Mesylate (RM) and it belongs to BCS class III...

The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole...

Objective: A simple, economical, robust and stability-indicating reverse phase high performance liquid chromatography method was developed and validated for the quantification of ropinirole hydrochloride in API and tablets to achieve shorter retention time, to minimize human error by avoiding the use of buffers and weighing procedure and analyze more number of samples in shorter period of time with good accuracy. Methods: The chromatographic conditions for separation of ropinirole hydrochloride was carried out using Gemini NX C18 column (15 cm x 4.6 mm), 5 µm particle size with the mobile phase composing of methanol: acetonitrile (70:30 v/v), delivered at flow rate 0.7 ml/min and UV detection wavelength at 250 nm. Results: The retention time was observed at 2.718 min. The system suitability results were found to be within limits. The method was precise, with lower than 2 %RSD and the calibration curve was linear (r2=1) over a concentration range of 2.5-160 µg/ml. The detection and quantification limit was found to be 0.045 µg/ml and 0.15 µg/ml, respectively. Recovery of the drug was found between 100.09-100.19%. The assay of ropinirole hydrochloride in ROPITOR® and ROPARK® tablets were found to be 100.4 and 103.60 %, respectively. The forced degradation studies were carried out to demonstrate the specificity of the method by exposing the API under conditions of hydrolysis, oxidation, thermal and photolytic as per ICH Q1A(R2) guidelines. Conclusion: The low coefficient of variation and agreeable recovery confirmed that the newly developed method could be employed for routine analysis of ropinirole hydrochloride in API and tablets.