Berardo de Jesus Rodriguez
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Berardo de Jesus Rodriguez has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Claire Chevaleyre
Institut National de la Recherche Agronomique (INRA), UR1282, Infectiologie Animale et Santé Publique, F-37380 Nouzilly, Tours, France
1 shared publication - Daniel Mollé
UMR Science et Technologie du Lait et de l'Oeuf, INRA-Agrocampus 1253, 65 rue de Saint-Brieuc, 35042 Rennes CEDEX, France
1 shared publication - François Boulay
Commissariat à l'Energie Atomique (CEA), DSV, iRTSV, Laboratoire Biochimie et Biophysique des Systèmes Intégrés, Grenoble, F-38054, France. CNRS, UMR 5092, 17 rue des Martyrs, Grenoble F-38054, France. Université Joseph Fourier, Grenoble, F-38000, France
1 shared publication - François Meurens
Swine and Poultry Infectious Diseases Research Center, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC J2S 2M2, Canada
1 shared publication - Gwénaële Henry
UMR Science et Technologie du Lait et de l'Oeuf, INRA-Agrocampus 1253, 65 rue de Saint-Brieuc, 35042 Rennes CEDEX, France
1 shared publication - Henri Salmon
Institut National de la Recherche Agronomique (INRA), Lymphocytes et Immunité des Muqueuses UR1282, Infectiologie Animale et Santé Publique F-37380, Nouzilly (Tours), France
1 shared publication
Latest Publications
- Open Access
- 23 January 2009
- Published by Springer Nature in BMC Immunology
- Vol. 10 (1) , 4
Identification in milk of a serum amyloid A peptide chemoattractant for B lymphoblasts
Background: Normal mammary gland contains an extravascular population of B lymphoblasts, precursors of the immunoglobulin plasma cells that play a key role in the passive protection of neonates by secreting immunoglobulins to colostrum and milk. We investigated the presence of chemoattractants in the milk by analysing the chemoattractant activity of various fractions of this secretion. Milk chemoattractants are potentially involved in the recruitment of lymphocytes from the maternal bloodstream in lactating mammary glands.Results: The dilution-related lymphoid cell chemoattraction of whey was associated with a < 10 kDa ultrafiltrate. Active fractions were purified by reverse-phase high performance liquid chromatography. Two peptides of 2.7 kDa (DMREANYKNSDKYFHARGNYDAA) and 1 kDa (RPPGLPDKY) were identified as fragments of the SAA protein family, tentatively identified as SAA2. Only the 2.7 kDa synthetic peptide displayed chemotactic activity, at two different optimal concentrations. At the lower concentration (3.7 nM), it attracted B-cell lymphoblasts, whereas at the higher (3.7 μM), it attracted B lymphocytes. Then, the SAA mRNA expression was analysed and we observed more SAA transcripts during lactation than gestation.Conclusion: These data are consistent with the SAA23–45fragment being involved in preplasma B-cell recruitment to the mammary gland and resultant benefit to the neonate.
- 23 January 2009
- Published by Springer Nature in BMC Immunology
- Vol. 10 (1) , 4
Open AccessIdentification in milk of a serum amyloid A peptide chemoattractant for B lymphoblasts
Background: Normal mammary gland contains an extravascular population of B lymphoblasts, precursors of the immunoglobulin plasma cells that play a key role in the passive protection of neonates by secreting immunoglobulins to colostrum and milk. We investigated the presence of chemoattractants in the milk by analysing the chemoattractant activity of various fractions of this secretion. Milk chemoattractants are potentially involved in the recruitment of lymphocytes from the maternal bloodstream in lactating mammary glands.Results: The dilution-related lymphoid cell chemoattraction of whey was associated with a < 10 kDa ultrafiltrate. Active fractions were purified by reverse-phase high performance liquid chromatography. Two peptides of 2.7 kDa (DMREANYKNSDKYFHARGNYDAA) and 1 kDa (RPPGLPDKY) were identified as fragments of the SAA protein family, tentatively identified as SAA2. Only the 2.7 kDa synthetic peptide displayed chemotactic activity, at two different optimal concentrations. At the lower concentration (3.7 nM), it attracted B-cell lymphoblasts, whereas at the higher (3.7 μM), it attracted B lymphocytes. Then, the SAA mRNA expression was analysed and we observed more SAA transcripts during lactation than gestation.Conclusion: These data are consistent with the SAA23–45fragment being involved in preplasma B-cell recruitment to the mammary gland and resultant benefit to the neonate.