Chi Chen
Research Subjects
Chi Chen has a total of 1 co-authors. Here are the top co-authors by number of shared publications:
- Carton W. Chen
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Shih-Pai, Taipei 112, Taiwan
1 shared publication
Latest Publications
- Open Access
- 1 January 2007
- Published by Springer Nature in BMC Genomics
- Vol. 8 (1) , 286
Quantitative analysis of mutation and selection pressures on base composition skews in bacterial chromosomes
Most bacterial chromosomes exhibit asymmetry of base composition with respect to leading vs. lagging strands (GC and AT skews). These skews reflect mainly those in protein coding sequences, which are driven by asymmetric mutation pressures during replication and transcription (notably asymmetric cytosine deamination) plus subsequent selection for preferred structures, signals, amino acid or codons. The transcription-associated effects but not the replication-associated effects contribute to the overall skews through the uneven distribution of the coding sequences on the leading and lagging strands.
- 1 January 2007
- Published by Springer Nature in BMC Genomics
- Vol. 8 (1) , 286
Open AccessQuantitative analysis of mutation and selection pressures on base composition skews in bacterial chromosomes
Most bacterial chromosomes exhibit asymmetry of base composition with respect to leading vs. lagging strands (GC and AT skews). These skews reflect mainly those in protein coding sequences, which are driven by asymmetric mutation pressures during replication and transcription (notably asymmetric cytosine deamination) plus subsequent selection for preferred structures, signals, amino acid or codons. The transcription-associated effects but not the replication-associated effects contribute to the overall skews through the uneven distribution of the coding sequences on the leading and lagging strands.